Thiazoles
Medchemexpress LLC PNR-7-02 | 1633660-76-0 | 98.0% | 445.92 | C24H16ClN3O2S | 5 MG
A small-molecule inhibitor of DNA polymerase eta (Pol η) supplied for research use. Provided as a solid in milligram quantities for in vitro and preclinical studies, it is suitable for mechanism-of-action experiments and combination cytotoxicity assays.
- High purity: 98.0%.
- Molecular weight 445.92.
- Chemical formula C24H16ClN3O2S.
- Provided in a 5 MG vial suitable for laboratory assays.
- Intended for in vitro pharmacology and mechanism-of-action studies.
Medchemexpress LLC PNR-7-02 | 1633660-76-0 | 98.0% | 445.92 | C24H16ClN3O2S | 50 MG
PNR-7-02 is a small-molecule research inhibitor of DNA polymerase eta (Pol η). It is an indole thio-barbituric acid derivative reported to inhibit Pol η (IC50 ≈ 8 μM), with activity against hRev1 and DNA polymerase λ, and reported synergy with cisplatin in certain cancer cell lines.
- Purity 98.0%.
- Molecular weight 445.92.
- Chemical formula C24H16ClN3O2S.
- Appearance solid.
- Recommended solvent DMSO; solubility note: 1 mg/mL, ultrasonic and warming, heat to 60°C.
- Storage powder: -20°C for 3 years; in solvent: -80°C for 6 months.
Medchemexpress LLC PNR-7-02 | 1633660-76-0 | 98.0% | 445.92 | C24H16ClN3O2S | 10 MG
PNR-7-02 is a small-molecule Pol η (DNA polymerase eta) inhibitor provided for preclinical biochemical and cell-based research. It is supplied as a solid research compound and is not for human or veterinary use.
- Purity 98.0%.
- Molecular weight 445.92 g/mol.
- Chemical formula C24H16ClN3O2S.
- CAS number 1633660-76-0.
- Soluble in dimethyl sulfoxide (DMSO).
- Pack size 10 mg.
- Intended for research use only.
Medchemexpress LLC PNR-7-02 | 1633660-76-0 | 98.0% | 445.92 g·mol⁻¹ | C24H16ClN3O2S | 25 MG
PNR-7-02 is a small-molecule inhibitor of DNA polymerase eta (Pol η) used in research on translesion synthesis and polymerase-mediated drug resistance. It is an indole thio-barbituric acid derivative reported to inhibit Pol η (IC50 ≈ 8 μM) and to act synergistically with cisplatin in cancer cell lines.
- Inhibits Pol η with reported IC50 ≈ 8 μM
- Also shows activity against hRev1 and hpol λ
- High purity (98.0%) suitable for biochemical assays
- Available as a 25 MG package, other sizes available
- Indole thio-barbituric acid scaffold, useful as a small-molecule probe
- For research use only; not for human or clinical use