330-0915-OEM: EZwaste Breakthrough Indicator (10pk). EZwaste Replacement Breakthrough Indicators come in packs of 1, 2, 5, 10, 25, or 50. Foxx Life SciencesÆ Breakthrough Indicator is a qualitative colorimetric indicator for the exhaustion and end-of-service life of low-flow filters. The indicator changes from orange to red when the filter needs to be replaced. The indicator is designed to provide real-time indication of the breakthrough of HPLC solvents vapors, including: Acetone Acetonitrile Chloroform DCM/Methylene Chloride (Dichloromethane) Ethanol Ethyl Acetate HFIP Hexafluoroisopropanol Methanol Phenol Sulfolane THF (Tetrahydrofuran)