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The lyophilized carp Vtg may be used as a positive control in immunoblotting. Freshly reconstituted Vtg may also be used as a standard in a quantitative ELISA. This product contains bovine serum albumin which will appear as a strong protein band in acrylamide gels.
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A GCGR GLP-1R and GIP receptor agonist induces cAMP accumulation in HEK293 cells expressing the human GCGR GLP-1R or GIP receptor (EC50s 5.79 0.775 and 0.0643 nM respectively) decreases plasma glucose levels in an intraperitoneal glucose tolerance test in mice from 0.1-30 nmol/kg decreases body weight calorie intake fat mass and lean mass in a mouse model of diet-induced obesity acute administration delays gastric emptying and chronic administration for 10 days decreases food intake and body weight in mice
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A disulfide bond-containing ionizable cationic lipid has been used in the generation of LNPs for plasmid delivery in vitro and in vivo LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP increase RRSP levels and decrease Ras levels in and reduce the viability of HeLa cancer cells LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart liver spleen lungs and kidneys as well as decrease tumor volume without reducing body weight in an HCT116 colorectal cancer mouse xenograft model
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A flavonoid with diverse biological activities inhibits biofilm formation by S. aureus B. subtilis P. aeruginosa and E. coli at 32 Ug/ml rinduces cytotoxicity in SW460 and DLD-1 cancer cells (IC50s 29.41 and 30.93 UM respectively) but not HT-29 or HepG2 cancer cells (IC50s 40 UM for both) decreases LPS-induced NO production and secreted TNF-a and IL-1B levels in J774A.1 macrophages at 0.01 UM alone and in combination with NGF increases neurite outgrowths levels of GAP43 and decreases serum deprivation-induced death in PC12 cells at 10 UM
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