ELISA Substrates and Reagents
ABclonal Technology Phospho-NRF2-S40 Rabbit pAb
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene.
![ABclonal Technology [KO Validated] ERK2 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000136563.jpg-250.jpg)
ABclonal Technology [KO Validated] ERK2 Rabbit pAb
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Cayman Chemical DecorIn Long Isoformhumn1mg
Source: Recombinant human C-terminal His-tagged decorin expressed in HEK293 cells • Amino acids: 17-359 • MW: 39.4 kDa
ABclonal Technology Phospho-GYS1-S641 Rabbit pAb
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-SRC Family-Y416 Rabbit pAb
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Genscript Corporation CEACAM-5/CD66eBiotin His
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated
ABclonal Technology Phospho-E-Cadherin-S838/S840 Rabbit pAb
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
ABclonal Technology Phospho-Akt-S473 Rabbit pAb
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Bioss JNK - Thr-183/Tyr-185 Phospho
JNK (Thr-183/Tyr-185) Primary Antibody Unconjugated Host Species Mouse Target Species Human Mouse Rat Clonality Monoclonal Applications WB M268Concentration Size 100 ul Storage Buffer PBS 1 mg/ml BSA 0 05% NaN3 and 50% glycerol
Cayman Chemical THUNDRTotal RPS6 TRFRET C 96
Sandwich TR-FRET immunoassay for semi-quantitative detection of Total Ribosomal Protein S6 (both phosphorylated and non-phosphorylated RPS6) in cell lysates.
ABclonal Technology Phospho-PRKCQ-T538 Rabbit pAb
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Cayman Chemical 11keto TStosTRon ELISA n
A DGAT1 inhibitor (IC50 57 nM) selective for DGAT1 over DGAT2 ACAT-1 and ACAT-2 (IC50s >10000 nM for all) inhibits HCV replication in HCV-infected Huh7.5 cells at 50 UM. inhibits palmitic acid-induced apoptosis and increases in triglyceride levels in MIN6 cells decreases serum triglyceride levels in an oral lipid tolerance test in dogs at 1 mg/kg
ABclonal Technology Phospho-Akt-S473 Rabbit mAb
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts AKT1 and the related AKT2 are activated by platelet-derived growth factor The activation is rapid and specific and it is abrogated by mutations in the pleckstrin homology domain of AKT1 It was shown that the activation occurs through phosphatidylinositol 3-kinase In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine threonine kinase AKT1 which then phosphorylates and inactivates components of the apoptotic machinery Mutations in this gene have been associated with the Proteus syndrome Multiple alternatively spliced transcript variants have been found for this gene [provided by RefSeq Jul 2011]
ABclonal Technology Phospho-NF-B2-S866/S870
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner The p100 full-length protein is co-translationally processed into a p52 active form Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas some of which may result in the formation of fusion proteins There is a pseudogene for this gene on chromosome 18 Alternative splicing results in multiple transcript variants
Bioss Osteopontin - N-terminal regio
Osteopontin (N-terminal region) Primary Antibody Unconjugated Host Species Mouse Target Species Human Mouse Rat Clonality Monoclonal Applications WB M574Concentration Size 100 ul Storage Buffer PBS 1 mg/ml BSA 0 05% NaN3 and 50% glycerol