ELISA Substrates and Reagents
ABclonal Technology Phospho-NF-kB p65/RelA-T435 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
![ABclonal Technology [KO Validated] ErbB3/HER3 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000135007.jpg-250.jpg)
ABclonal Technology [KO Validated] ErbB3/HER3 Rabbit pAb
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The protein has a neuregulin-binding domain but lacks an active kinase domain, so it can bind the ligand but cannot transmit the signal. However, it forms heterodimers with other EGFR family members with kinase activity, activating pathways that lead to cell proliferation or differentiation. Gene amplification or overexpression of this protein has been observed in cancers like prostate, bladder, and breast tumors. Alternate splice variants have been characterized, including one isoform that lacks the intermembrane region and is secreted outside the cell, where it modulates the activity of the membrane-bound form. Other splice variants have been reported but are not fully characterized.
American Research Products Inc Mouse Sonic hedgehog protein
Mouse Sonic hedgehog protein (SHH) ELISA kit from CUSABIO Detection Range 28 pg/mL-1800 pg/mL Sensitivity 7 pg/mL Sample serum plasma tissue homogenates cell lysates Method Sandwich
ABclonal Technology Phospho-PLN-T17 Rabbit pAb
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Sino Biological Protein Mouse INSR ET FREE1MG
A DNA sequence encoding the Mouse INSR (NP_034698.2) (Met1-Lys946) was expressed with a polyhistidine tag at the C-terminus.
ABclonal Technology Phospho-EPHA2-S897 Rabbit pAb
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Revvity Health Sciences Inc HTRF Human Phospho-FLT3 (Tyr842) Detection Kit, 10,000 Assay Points
HTRF Human Phospho-FLT3 (Tyr842) Detection Kit, 10,000 Assay Points
ABclonal Technology Phospho-E-Cadherin-S838/S840 Rabbit pAb
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Bioss Phospho-PAK4/5/6
PAK4/5/6 (Ser474/Ser602/Ser560) Primary Antibody Unconjugated Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB FCM RecombinantConcentration 1ug/ul Size 100 ul Storage Buffer 10mM phosphate buffered saline(pH 7 4) with 150mM sodium chloride 0 05% BSA 0 02% sodium azide and 50% glycerol
Cayman Chemical THUNDRTotal RPS6 TRFRET C 2400
Sandwich TR-FRET immunoassay for semi-quantitative detection of Total Ribosomal Protein S6 (both phosphorylated and non-phosphorylated RPS6) in cell lysates.
Kingfisher Biotech Inc Mouse IL-17A ELISpot - Up to two (2) ELISpot assays
Mouse IL-17A ELISpot contains Capture Antibody, Standard Control, and Detection Antibody for development of up to two (2) ELISpot assays. Other required materials and reagents are not supplied. The antibodies have been determined to function in an ELISpot with the Standard Control provided. Components may also be purchased separately. For research use only. Made in the USA