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Agarose and acrylamide powders, buffers, diluents, markers and stains for protein/nucleic acid electrophoresis; featuring concentration, grade, melting point, capacity to stabilize, control concentration, denature, reduce, and mark target molecules.
This gene encodes a member of the Notch family, a group of Type 1 transmembrane proteins with an extracellular domain containing multiple epidermal growth factor-like (EGF) repeats and an intracellular domain with diverse domains. Notch family proteins regulate developmental processes by controlling cell fate decisions through an evolutionarily conserved intercellular signaling pathway. In Drosophila, Notch interacts with ligands (delta, serrate) to regulate development, and similar ligands have been identified in humans, though their interactions with human Notch proteins are not fully understood. This protein is cleaved in the trans-Golgi network and presented as a heterodimer on the cell surface, acting as a receptor for membrane-bound ligands. It may be involved in vascular, renal, and hepatic development. Two transcript variants encoding different isoforms have been identified.
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Protein G was initially isolated from G148 a human group G Streptococcal strain. It is a cell wall protein and shows high affinity to IgG (immunoglobulin G). It has a putative molecular weight of 30 000Da. It interacts with all subclasses of human IgG and also binds to mouse rabbit and goat IgG.
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This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.
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This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified.
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The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.
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The Gyros Rexxip HN-max is a specialized buffer designed for optimizing immunoassay performance within certain systems. This buffer is particularly effective for positively-charged analytes, offering properties that enhance assay accuracy and reliability. Key components of the formulation help neutralize unwanted antibodies and increase ionic strength, which together aid in preserving sample integrity and improving data quality in research settings.
Volume: 25 mL
Formulation: 2x standard formulation
Application: Positively-charged analytes
Special feature: Neutralizes heterophilic antibodies
Benefits: Preserves sample integrity
Benefits: Enhances analyte-reagent binding
Benefits: Minimizes non-specific binding
Benefits: Improves data quality
Benefits: Reduces assay development time
Quality: Batch-to-batch consistency
Regulatory status: Research use only
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Quick-Load 1 kb Plus DNA Ladder is a pre-mixed, ready-to-load molecular weight marker containing bromophenol blue as a tracking dye. The DNA Ladder consists of proprietary plasmids which are digested to completion with appropriate restriction enzymes to yield 19 bands suitable for use as molecular weight standards for agarose gel electrophoresis. This digested DNA includes fragments ranging from 100 bp to 10 kb. The 0.5, 1.0 and 3.0 kb bands have increased intensity to serve as reference bands. NEB also offers a Quick-Load version of this ladder with purple dye.
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