Protein Molecular Weight Markers
ABclonal Technology DPYD Rabbit pAb
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.
![ABclonal Technology [KO Validated] CDKN2C/p18-INK4C Rabbit mAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000134929.jpg-250.jpg)
ABclonal Technology [KO Validated] CDKN2C/p18-INK4C Rabbit mAb
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
ABclonal Technology INPPL1 Rabbit pAb
The protein encoded by this gene is an SH2-containing 5-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
ABclonal Technology Steroidogenic factor-1 (SF-1/NR5A1) Rabbit pAb
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect.
ABclonal Technology ZGPAT Rabbit pAb
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane.
ABclonal Technology WBSCR27 Rabbit pAb
This gene encodes a protein belonging to ubiE/COQ5 methyltransferase family. The gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.22-q11.23.
ABclonal Technology BPIFB2 Rabbit pAb
This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20.
LAMDA BIOTECH INC AccuRuler + Protein Ladder 10
The AccuRuler Plus™ Prestained Protein Ladder is an extended-range protein molecular weight marker containing 12 pre-stained proteins spanning 10-245kDa. This multi-tube format includes distinctive red (75kDa) and green (25kDa) reference bands for easy molecular weight determination.
LAMDA BIOTECH INC AccuRuler Broad Protein Ladder
A pre-stained protein molecular weight marker containing 12 proteins with expanded range from 10 to 310 kDa. Designed for protein separation monitoring and molecular weight determination in electrophoresis and Western blot applications.
LAMDA BIOTECH INC AccuRuler Protein Ladder10 tb
The AccuRuler™ Prestained Protein Ladder is a precision protein molecular weight marker containing 10 pre-stained proteins spanning 10-180kDa. This multi-tube format includes distinctive red (75kDa) and green (25kDa) reference bands for easy molecular weight determination.
ABclonal Technology Cullin 3 Rabbit pAb
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology SFPQ Rabbit pAb
Enables DNA binding activity, histone deacetylase binding activity, and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin, nuclear matrix, and paraspeckles.
ABclonal Technology IL23R Rabbit pAb
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.