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ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively. It is intended for research use only and not sold to patients.
Reduces myocardial elastolytic activity and coronary microvascular perfusion injury in DBA/2 mice infected with EMC virus.
Decreases pathologic severity of myocardial lesions associated with murine viral myocarditis.
Can reverse advanced pulmonary vascular disease in rats.
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ZD-4190 is a potent orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling used for the treatment of cancer
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD 2138 is a selective 5-lipoxygenase inhibitor, suitable for research in areas such as asthma. This product is provided as an off-white to light yellow solid with a high purity.
High purity: 99.9% (LCMS)
Off-white to light yellow solid appearance
Consistent with chemical structure (1H NMR, LCMS)
Suitable for research use
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD-0892 is a small-molecule, selective inhibitor of neutrophil elastase with reported Ki values of 6.7 nM for human neutrophil elastase and 200 nM for porcine pancreatic elastase. It is supplied as a research-grade reagent (purity 95%) and is used in biochemical and enzymatic studies to probe elastase-dependent pathways.
Selective inhibition of human neutrophil elastase (Ki ~6.7 nM).
Also inhibits porcine pancreatic elastase (Ki ~200 nM).
Suitable for biochemical and enzymatic assays.
Provided at research-grade purity for reproducible results.
Small-molecule compound with molecular weight approximately 499.5 g/mol.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD-4190 is a potent orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling used for the treatment of cancer
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ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
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A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively); modulates the sinoatrial node and slows heart rate; reduces neuropathic pain in several animal models
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD-0892 is a selective and potent inhibitor of neutrophil elastase. It exhibits high affinity for human neutrophil elastase and porcine pancreatic elastase, making it suitable for targeted research.
Selective and potent inhibitor of neutrophil elastase
Suitable for in vitro and in vivo studies
Available in solid form for various research needs
Backed by scientific publications for its applications
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD 7155 hydrochloride is a selective, nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor supplied as a 10 mM solution in a 1 mL vial for research use. It blocks AT1-mediated signaling in pharmacology and physiological studies and is provided with batch-specific purity data (COA).
Selective AT1 receptor antagonist useful for receptor pharmacology studies.
Supplied as a 10 mM solution for direct use in assays.
Provided with certificate of analysis and batch purity information.
Available in multiple pack sizes for assay scale flexibility.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD 2138 is a chemical compound identified by CAS No. 140841-32-3. It has a molecular formula of C23H24FNO4 and a molecular weight of 397.44. This compound is typically an off-white to light yellow solid with a high purity of 99.9%.
Chemical name: 2(1H)-Quinolinone, 6-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-methyl-
Molecular formula: C23H24FNO4
Molecular weight: 397.44
Purity: 99.9%
Appearance: Off-white to light yellow solid
Storage (powder): -20°C for 3 years; 4°C for 2 years
Storage (in solvent): -80°C for 6 months; -20°C for 1 month
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD 2138 is identified as 2(1H)-Quinolinone, 6-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-methyl-. It has a molecular formula of C23H24FNO4 and a molecular weight of 397.44. This compound is typically an off-white to light yellow solid with a high purity of 99.9% confirmed by LCMS.
High purity (99.9%) confirmed by LCMS.
Consistent structure verified by 1H NMR spectrum.
Available as an off-white to light yellow solid.
Stable for extended periods under specified storage conditions.
For research use only.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ZD-4190 is a potent orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling used for the treatment of cancer
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More