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The Cuvette Qualification Filter Kit for the cuvette based Thermo Scientfic™ NanoDrop™ OneC and NanoDrop™ 2000c Spectrophotometers is an essential tool for ensuring the optimal performance of your spectrophotometers. This kit provides you with the necessary filters for accurate cuvette qualification testing.
Fisher Scientific Edge Order by 2 p.m. for same-day shipping. Learn More
A cell-permeable naphthol derivative that acts as a highly potent and selective inhibitor of cAMP response element-binding protein (CREB)-mediated gene transcription (IC50 81 nM by CREB RLuc reporter assay with transfected HEK 293T cells). Also shown to inhibit forskolin-stimulated transcription of Nurr1/NR4A2 (~ 50 nM). Diminishes CREB phosphorylation and reduces colony forming ability of wild-type AML cells. Inhibits the growth of cancer cells (GI50 46 73 310 and 470 nM for MDA-MB-468 MDA-MB-231 MCf-7 and A549 respectively) without affecting normal cells. Completely suppresses the growth of MDA-MB-468 xenografts in mice (~ 10 mg/kg i.p. 5 days/week for 5 weeks).Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More