Hydroxybenzoic Acid Derivatives
Medchemexpress LLC Direct Black 38 | 1937-37-7 | 10 G
Direct Black 38 (Chlorazol Black E) is a benzidine-based azo dye. Primarily used for textile dyeing, it is biodegradable through reduction by microbial enzymes, which breaks its azo bonds to release benzidine and 4-aminobiphenyl. This compound is valuable in environmental toxicology, wastewater treatment, and carcinogenicity studies, though its metabolite benzidine is classified as a human carcinogen.
- Benzidine-based azo dye
- Primarily used for textile dyeing
- Biodegradable by microbial enzymes
- Relevant in environmental toxicology, wastewater treatment, and carcinogenicity studies
- Metabolite benzidine is a human carcinogen
- Decolorized by Enterococcus gallinarum
- Soluble in DMSO and H2O
Medchemexpress LLC Cloperastine fendizoate | 85187-37-7 | 99.5% | 10 G
Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. This compound possesses antitussive and antiedemic activity, relaxing bronchial musculature. It is a drug with a central antitussive effect, endowed with an antihistaminic and papaverine-like activity, similar to codeine but without its narcotic effects.
- Inhibits hERG K+ currents.
- Possesses antitussive and antiedemic activity.
- Relaxes bronchial musculature.
- Exhibits a central antitussive effect.
- Endowed with antihistaminic and papaverine-like activity.
- Similar to codeine but without its narcotic effects.
Sigma Aldrich 5-Bromo-7-methoxy-1-benzofuran-2-carboxylic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Apexbio Technology LLC PFI 4 900305-37-5 10mM (in 1mL DMSO)
PFI 4 (CAS 900305-37-5) is a cell-permeable potent and selective inhibitor of the BRPF1 bromodomain exhibiting a pIC50 of 7 1 and a pKd of 8 0 BRPF1 belongs to the BRPF family which serves as a scaffold for the assembly of MYST family histone acetyltransferase (HAT) complexes involved in chromatin remodeling and transcriptional regulation In BROMOscan assays PFI 4 demonstrates high selectivity for BRPF1 compared to other bromodomains Cellular protein interaction studies reveal that PFI 4 disrupts BRPF1 association with chromatin enabling detailed investigation of BRPF1 function in epigenetic regulation and development
Apexbio Technology LLC 4'-Demethylepipodophyllotoxin 6559-91-7 10mM (in 1mL DMSO)
4 -Demethylepipodophyllotoxin (CAS 6559-91-7) is a small molecule structurally related to podophyllotoxin and serves as an intermediate in the synthesis of podophyllotoxin-derived compounds It exhibits pronounced cytotoxicity in vitro with EC50 values of 0 31 M in HL60 cells and 0 37 M in HepG2 cells after 48 hours as assessed by MTT assay Analogues such as 4-TMP-DMEP demonstrate even lower EC50 values (0 24 0 11 M) across multiple tumor cell lines reflecting enhanced potency compared to related compounds In in vivo studies pre-administration of this class of molecules has been shown to reduce tumor incidence growth and malignant conversion rates in animal models These properties support its utility in investigating mechanisms of tumor cytotoxicity and as a research scaffold in anticancer drug development