Oligonucleotides
Medchemexpress LLC PROTAC STING Degrader-1 | 2762552-74-7 | C34H33N7O10 | 5 MG
PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway, demonstrating high anti-inflammatory efficacy with a DC50 of 3.2 μM. It is valuable for studying diseases such as acute kidney injury and inflammatory bowel diseases.
- Targets the STING pathway with a DC50 of 3.2 μM.
- Exhibits high anti-inflammatory efficacy.
- Useful for studying acute kidney injury and inflammatory bowel diseases.
- Downregulates STING pathway signals (IFN-β, IL-6, CXCL10) in THP-1 cells.
- Degrades STING dose- and time-dependently.
- Demonstrates no significant cytotoxicity below 10 μM.
- Alleviates ischemic symptoms and reduces kidney weights in acute kidney injury mouse models.
- Ameliorates severity of DSS-induced colitis in mice.
ABclonal Technology Von Hippel Lindau/VHL
This gene encodes a component of a ubiquitination complex The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF) which is a transcription factor that plays a central role in the regulation of gene expression by oxygen In addition to oxygen-related gene expression this protein plays a role in many other cellular processes including cilia formation cytokine signaling regulation of senescence and formation of the extracellular matrix Variants of this gene are associated with von Hippel-Lindau syndrome pheochromocytoma erythrocytosis renal cell carcinoma and cerebellar hemangioblastoma
ABclonal Technology Von Hippel Lindau/VHL
This gene encodes a component of a ubiquitination complex The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF) which is a transcription factor that plays a central role in the regulation of gene expression by oxygen In addition to oxygen-related gene expression this protein plays a role in many other cellular processes including cilia formation cytokine signaling regulation of senescence and formation of the extracellular matrix Variants of this gene are associated with von Hippel-Lindau syndrome pheochromocytoma erythrocytosis renal cell carcinoma and cerebellar hemangioblastoma
ABclonal Technology Non-pAct -CateninS33/S37/T41
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete Finally this protein binds to the product of the APC gene which is mutated in adenomatous polyposis of the colon Mutations in this gene are a cause of colorectal cancer (CRC) pilomatrixoma (PTR) medulloblastoma (MDB) and ovarian cancer Alternative splicing results in multiple transcript variants
Cayman Chemical Krebs Cycle stnd MIXure 100mL
A mixture of seven non-volatile acid Krebs cycle intermediates; intended for use as a reference standard for the detection of these intermediates in various sample types by GC-MS
Cayman Chemical Humn PGlycoproteIn MDR1 D 96
The materials provided in the assay kit for MDR1 / Human P-Glycoprotein Drug Interaction are formatted to allow for two independent 48-well assay setups. EAch aliquot of HCT-Pgp Cells is provided as a single-use assay reagent and provides sufficient volume to dispense 48 assay wells of HCT-Pgp cells into one 96-well plate. If desired, the two aliquots of HCT-Pgp cells may be thawed, combined to generate a single cell suspension, and then dispensed into all wells of an assay plate. The kit contains two aliquots of HCT-Pgp cells and two black, sterile, collagen-coated 96-well assay plates. In addition to HCT-Pgp cells and assay plates, this kit includes Cell Recovery Medium (CRM-p) used to perform a rapid thaw of the -80°C HCT-Pgp cells, Compound Screening Medium supplemented with daunorubicin (CSM+DR) used to prepare drug treatment media, Wash Buffer, two aliquots of Lysis Reagent, and the potent reference inhibitor Tariquidar.
Biotium SOX9 / SRY-box 9 (PCRP-SOX9-1E5), 0.2mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19,000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are n
Apexbio Technology LLC EZ Cap Human PTEN mRNA 5x1mg (1mg/mL)
PTEN mRNA encodes a a tumor suppressor gene (Phosphatase and Tensin homolog deleted on chromosome 10) that antagonizes the activity of PI3K a key enzyme involved in anti-apoptotic and pro-tumorigenic Akt activation EZ Cap Human PTEN mRNA is provided at 1 mg/mL This mRNA is synthesized through co-transcriptional capping resulting in a Cap 1 structure The addition of poly(A) tail significantly enhances mRNA stability and lifetime both in vitro and in vivo Furthermore the poly(A) tail significantly contributes to improving the efficiency of translation initiation
Biotium CD43 (T-Cell Marker) (rSPN/1094), 0.2mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low ab
Alkali Scientific DNA & RNA Elution Buffer (EB Buffer) for PCR, Plasmid & Spin Column Cleanup, 500mL
DNA & RNA Elution Buffer is a high-purity solution designed for efficient recovery of nucleic acids during purification workflows. It is commonly used in spin column-based extraction kits for eluting DNA and RNA from silica membranes after washing steps. The buffer is formulated to be PCR compatible, ensuring that eluted nucleic acids can be directly used in downstream applications such as PCR amplification, qPCR, sequencing, and cloning without additional cleanup. Its low ionic strength helps maximize recovery while maintaining nucleic acid stability. This buffer is widely used in molecular biology laboratories for plasmid purification, genomic DNA extraction, and RNA isolation procedures where reliable and contaminant-free elution is required.