Oligonucleotides
AdipoGen iODN (inhibitory ODN) 2088 Endotoxin-free (sterile)
iODN (inhibitory ODN) 2088 Endotoxin-free (sterile), AdipoGen Life Sciences. Chemical. MW: 4,887g/mol. In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11-15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation.
SAPPHIRE NORTH AMERICA NaveniFlex Cell GR Atto647N
Detect proteins, protein-protein interactions, or protein modifications in cell samples. The assay is designed to be used with a goat and rabbit primary antibody pair. Detection with Atto647N fluorophore is included.
Medchemexpress LLC PROTAC STING degrader-3 | 98.04% | 752.73 | 5 MG
PROTAC STING degrader-3 is a STING PROTAC degrader that induces STING degradation via the ubiquitin-proteasome pathway. It exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling and has renal protective effects, being used in the study of acute kidney injury (AKI).
- Sting PROTAC degrader (DC50: 0.62 μM)
- Induces STING degradation via ubiquitin-proteasome pathway
- Exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling
- Renal protective effects for acute kidney injury (AKI) studies
- Potently degrades STING protein in THP-1 cells
- Blocks STING/NF-κB downstream signaling axis in HK-2 cells
- Demonstrates selective degradation of STING protein
- Favorable in vitro safety profile
- Improves renal function and survival in AKI mice
- Suppresses expression of STING proteins and inflammatory factors
Medchemexpress LLC DDB1 protein, human (sf9, His) | 96.0% | 10UG
DDB1 protein is a recombinant human DNA damage-binding protein 1 produced in Sf9 insect cells and supplied as an N-terminal His-tagged, 0.22 μm-filtered solution formulated for biochemical and cell-based research. The preparation is characterized for concentration, purity, molecular weight, endotoxin, and storage stability to support studies of DNA repair, ubiquitination, and protein-protein interactions.
- Recombinant human DDB1 expressed in Sf9 insect cells.
- N-terminal His tag for affinity purification and detection.
- Supplied in 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
- High purity (>90% by reducing SDS-PAGE) suitable for biochemical assays.
- Provided at 1.45 mg/mL to facilitate assay setup.
- Low endotoxin level (<1 EU/μg) for sensitive applications.
- Store at -80°C; stable short term at -20°C; avoid repeated freeze-thaw cycles.
Alkali Scientific DNA & RNA Elution Buffer (EB Buffer) for PCR, Plasmid & Spin Column Cleanup,1L
DNA & RNA Elution Buffer is a molecular biology grade solution formulated for efficient elution of purified nucleic acids from spin column systems. It is specifically designed to recover DNA and RNA bound to silica membranes following wash steps in purification workflows. The buffer composition ensures compatibility with sensitive downstream applications including PCR, qPCR, sequencing, and enzymatic reactions without requiring additional purification. Its optimized ionic strength promotes maximum nucleic acid recovery while preserving integrity and stability. This buffer is commonly used in plasmid preparation, genomic DNA extraction, and RNA purification processes, making it an essential reagent in research, clinical, and biotechnology laboratories.
Biotium SOX9 / SRY-box 9(rSOX9/2288), CF647 conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19, 000, full-length human proteins. Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Nucleus (Potential). Campomelic dysplasia (CMD1) : Rare, often lethal, dominantly inherited, congenital osteo-chondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognathia, flat face and hypertelorism are common. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and phot
Bioworld MagneZoom™ Oligo (dT)25, 2 mL
For isolation and purification of pure and intact mRNA from crude extract of animals and plant tissues. It is supplied as a suspension of super paramagnetic beads covalently coupled to Oligo (dT)25.Technical specification:Matrix: Silica coated Magnetic beadsLigand: Oligo (dT)25Binding Capacity: 2µg of mRNA/mg beads (10µg mRNA/1ml suspension)Particale size: 2-5µmSupplied as: 5mg/ml suspensionin 0.25M Tris, 0.02M EDTA, 0.1% Tween 20 and 0.02% Sodium AzideRequires MagneZoom™ paramagnetic bead station (20160000-1).
Medchemexpress LLC sEH inhibitor-1 (compound TCPU) | 1208549-68-1 | 99.6% | 50 MG
sEH inhibitor-1 (TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) used in preclinical research. It exhibits sub-nanomolar to low-nanomolar potency against human and murine sEH and is supplied as a research-grade powder.
- Potent sEH inhibition: IC50 0.4 nM (human), 5.3 nM (murine).
- Chemical formula C17H20F3N3O3, molecular weight 371.35 g/mol.
- High purity (~99.6%) suitable for research use.
- Supplied as a powder; recommended storage at -20°C for long-term, 4°C for shorter-term.
- Used in studies of inflammation, cardiovascular disease, and metabolic disorders.
- Available in a 50 mg pack size.
Cayman Chemical GrIes Reagent R1 5ea
Griess Reagent component for determination of nitrite in aqueous solutions.