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Filtered Search Results
Medchemexpress LLC Azithromycin-d3 | 163921-65-1 | 98.0% | 752.00 | 1 MG
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Azithromycin-d3 is the deuterium labeled Azithromycin, a macrolide antibiotic used for the treatment of various bacterial infections. It is suitable for applications requiring a tracer or an internal standard.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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eMolecules Medchem Express / EPZ011989 / 5mg / 446268037 / HY-16986 / / 1598383-40-4 / MFCD28964159 / 605.824 / C35H51N5O4
Medchem Express / EPZ011989 / 5mg / 446268037 / HY-16986 / / 1598383-40-4 / MFCD28964159 / 605.824 / C35H51N5O4
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Enzo Life Sciences Cycloheximide (1g). CAS: 66-81-9
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Antibiotic. Inhibits protein synthesis in eukaryotes by interfering with the translocation step. Induces apoptosis in tumor cell lines but can also delay or inhibit apoptosis induced by other agents. Widely used for selection of resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression. At 10µg/ml cycloheximide totally inhibits protein synthesis in mouse thymocytes. Alternative name: Actidione, Naramycin A, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide. Purity: ≥90% (HPLC). Appearance: White to light yellow powder. Solubility: Soluble in acetone, chloroform, ethanol, and methanol. Nearly insoluble in water. Long Term Storage: -20°C.
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Medchemexpress LLC Elzovantinib | 2271119-26-5 | 99.9% | 409.42 | 100 MG
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Elzovantinib (TPX-0022) is an oral-active inhibitor targeting SRC, MET, and c-FMS. It effectively suppresses MET autophosphorylation and downstream signaling pathways such as STAT3, ERK, and AKT in various cell lines. In in-vivo studies, Elzovantinib has demonstrated significant tumor regression and inhibition of tumor growth without causing body weight loss.
- Oral-active inhibitor
- Targets SRC, MET, and c-FMS
- Suppresses MET autophosphorylation and downstream signaling
- Demonstrates tumor regression in animal models
- Inhibits tumor growth
- No body weight loss observed in treated mice
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Medchemexpress LLC IRAK4-IN-4 50mg | 1850276-58-2 | 50 MG
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IRAK4-IN-4 is a research small-molecule inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with additional activity against cyclic GMP-AMP synthase (cGAS). Supplied as a light yellow solid with reported high purity, it is used in biochemical and cellular studies to probe IRAK4- and cGAS-mediated signaling pathways in inflammation and autoimmune disease research.
- Potent IRAK4 inhibition (IC50 2.8 nM).
- Potent cGAS inhibition (IC50 2.1 nM).
- High purity (99.6%).
- Light yellow solid physical form.
- Molecular weight 340.37 g/mol.
- Suitable for preclinical biochemical and cellular assays.
- Available in multiple small milligram pack sizes for research use.
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Medchemexpress LLC (Rac)-Sograzepide | 168161-71-5 | MFCD31544444 | 498.58 | 100 MG
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(Rac)-Sograzepide is an antagonist of the cholecystokinin B (CCK-B) receptor, which may help reduce gastric acid secretion.
- Antagonist of CCK-B receptor
- Potential to reduce gastric acid secretion
- Solid appearance
- White to off-white color
- For research use only
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ALADDIN SCIENTIFIC CORPORATION Ampicillin Na, 25g
Ampicillin is reported as slightly soluble in water practically insoluble in alcohol chloroform ether and fixed oils but soluble in dilute acids or bases The solution should not be autoclaved a stock solution should be sterilized through filtration and stored frozen where it will be stable for months Used to select for ampicillin resistance in mutated and transformed cells
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Medchemexpress LLC CHMFL-PI3KD-317 | 2244992-76-3 | 98.0% | 494.03 | 100 MG
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CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3Kδ inhibitor with an IC50 of 6 nM. It demonstrates over 10-1500 fold selectivity compared to other class I, II, and III PIKK family isoforms. The compound inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells with an EC50 of 4.3 nM and exhibits antiproliferative effects on cancer cells.
- Highly potent and selective PI3Kδ inhibitor
- Orally active
- Exhibits antiproliferative effects on cancer cells
- Favorable oral bioavailability
- Acceptable half-life
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Apexbio Technology LLC Cetylpyridinium Chloride 123-03-5 50mg
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Cetylpyridinium chloride (CAS 123-03-5) is a small-molecule inhibitor targeting microbial cell membranes It is designed to disrupt bacterial lipid bilayers thereby altering membrane permeability and inhibiting microbial viability Cetylpyridinium chloride exerts its biological activity primarily through membrane destabilization via positively charged cetylpyridinium ions interacting with negatively charged microbial surfaces In in vitro studies cetylpyridinium chloride demonstrates inhibitory activity with IC50 values ranging approximately between 0 5 to 10 M depending on microbial strain type and experimental conditions Based on these pharmacological properties cetylpyridinium chloride holds research potential in evaluating oral microbial inhibition biofilm formation interference and cell membrane-targeted antibacterial strategies
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Chem-Impex International, Inc. Tetracycline hydrochloride | 64-75-5 | MFCD00078142 | 25G
Tetracycline hydrochloride, 64-75-5, MFCD00078142, 25G
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Medchemexpress LLC Heparan sulfate | 9050-30-0 | 593.47 (monomer) | C12H19NO20S3 (monomer) | 50 MG
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Heparan sulfate is a naturally occurring linear glycosaminoglycan used as a research reagent to study growth factor signaling, extracellular matrix interactions, and enzymatic degradation. It is supplied as a purified polysaccharide suitable for biochemical assays and cell-based studies.
- Naturally occurring linear glycosaminoglycan.
- Used to study growth factor and extracellular matrix interactions.
- Soluble in water for assay preparation.
- Monomer formula C12H19NO20S3; monomer MW 593.47.
- Available in multiple package sizes including 50 mg.
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Medchemexpress LLC Vancomycin hydrochloride | 1404-93-9 | 99.4% | 1485.71 | 1 ML
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Vancomycin hydrochloride is an antibiotic used for treating bacterial infections. Its mechanism of action involves inhibiting the second stage of cell wall synthesis in susceptible bacteria. Additionally, vancomycin modifies the permeability of the cell membrane and selectively prevents ribonucleic acid synthesis. This product is for research use only and has not been fully validated for medical applications.
- Inhibits bacterial cell wall synthesis
- Modifies cell membrane permeability
- Selectively inhibits ribonucleic acid synthesis
- Acts as an antibiotic
- Relevant for autophagy research
- Applicable in infection research
- Used in cancer research
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Medchemexpress LLC Tiotropium Bromide | 136310-93-5 | 99.9% | 472.42 | 500 MG
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Tiotropium Bromide is a potent muscarinic acetylcholine receptor (mAChR) antagonist. It works by blocking the binding of acetylcholine, which prevents the opening of ligand-gated ion channels. This action leads to the cessation of neuronal signaling and muscle relaxation. As a long-acting, 24-hour anticholinergic bronchodilator, it is widely used in the management of chronic obstructive pulmonary disease and can also alleviate symptoms in cases complicated by chronic heart failure.
- mAChR antagonist
- Blocks acetylcholine binding
- Leads to muscle relaxation
- 24-hour anticholinergic bronchodilator
- Manages chronic obstructive pulmonary disease
- Improves symptoms in chronic heart failure complications
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Medchemexpress LLC TTA-A2 | 953778-63-7 | 99.3% | 378.39 | 100 MG
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TTA-A2 is a potent, selective, and orally active T-type voltage-gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. It is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of various human neurological diseases, including sleep disorders and epilepsy.
- Potent, selective, orally active T-type voltage-gated calcium channel antagonist.
- Reduced pregnane X receptor (PXR) activation.
- Equally potent against Cav3.1 and Cav3.2 channels.
- Used in research for neurological diseases, sleep disorders, and epilepsy.
- Exhibits high affinity in α1I binding assay (Ki of 1.2 nM).
- Excellent selectivity over hERG potassium and L-type calcium channels.
- Modifies sleep architecture in rats and mice.
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Medchemexpress LLC D-α-Hydroxyglutaric acid | 13095-47-1 | 148.11 | 10MG
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D-α-Hydroxyglutaric acid is the primary metabolite accumulating in D-2-hydroxyglutaric aciduria, a neurometabolic disease. It acts as a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases. This compound also enhances reactive oxygen species (ROS) production, binds to and inhibits ATP synthase, and suppresses mTOR signaling. It accumulates in human cancers with specific mutations in IDH1 and IDH2 genes.
- Primary metabolite in D-2-hydroxyglutaric aciduria
- Weak competitive antagonist of α-ketoglutarate (α-KG)
- Inhibits multiple α-KG-dependent dioxygenases
- Increases reactive oxygen species (ROS) production
- Binds and inhibits ATP synthase
- Inhibits mTOR signaling
- Accumulates in human cancers with IDH1 and IDH2 mutations
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