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Filtered Search Results
Alkali Scientific Spectinomycin Sulfate, 1 G
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Spectinomycin Sulfate, available in a 1g powder form, is an antibiotic used for the treatment of bacterial infections caused by Gram-negative bacteria. This compound is particularly effective against Neisseria gonorrhoeae infections, especially in cases resistant to penicillin. Spectinomycin works by inhibiting protein synthesis in bacteria, ultimately preventing bacterial cell growth. In clinical settings, it is used when other treatments fail, and in laboratory settings, it is commonly used to study bacterial genetics and resistance mechanisms. The 1g size is ideal for small-scale experiments and targeted therapeutic use, offering sufficient material for both research and clinical applications.
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Apexbio Technology LLC Clarithromycin 81103-11-9 10mM (in 1mL DMSO)
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Clarithromycin is a macrolide antibiotic exhibiting inhibitory activity against the cytochrome P450 isoform CYP3A a critical enzyme involved in drug metabolism Through CYP3A inhibition clarithromycin elevates the plasma concentrations of substrates notably statins thereby potentially altering their pharmacokinetic profiles Clarithromycin demonstrates potent CYP3A inhibition with an approximate IC50 value of 32 M making it suitable for in vitro and in vivo research investigating drug-drug interaction mechanisms and pharmacokinetic studies involving CYP3A-dependent pathways Experimental applications include assessing clarithromycin s impact on hepatic CYP3A activity evaluating the metabolic stability of CYP substrates and characterizing interaction risks between concurrent medications that share CYP3A-mediated metabolic routes
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Apexbio Technology LLC Streptomycin sulfate 3810-74-0 10mM (in 1mL H2O)
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Streptomycin sulfate is an aminoglycoside antibiotic targeting the bacterial 30S ribosomal subunit It is designed to inhibit bacterial protein synthesis thereby suppressing bacterial proliferation Streptomycin sulfate exerts its biological activity primarily through inhibition of mRNA translation by binding to the 30S subunit which impairs initiation and elongation processes during protein synthesis and disrupts the ribosome mRNA complex Based on these pharmacological properties streptomycin sulfate holds research potential in microbiological experimentation susceptibility assays bacterial resistance profiling microbial genetics studies and screening of transgenic cells expressing antibiotic-resistance markers
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Enzo Life Sciences Oligomycin, (5mg), CAS Number: 1404-19-9
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F-ATPase inhibitor. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis. MW: 791.1 (Oligomycin A). CAS Number: 1404-19-9. MI: 14: 6833. Purity: ≥90% (HPLC, TLC). Appearance: White to faint yellow powder. Solubility: Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml). Long Term Storage: +4°C
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eMolecules 62893-20-3 | Cefoperazone sodium | Combi-Blocks | MFCD07793331 | 667.650 | C25H26N9NaO8S2 | 98.000 | [Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c2ccc(O)cc2)C(=O)C1=O | 1g | 117563896
Cefoperazone sodium | Combi-Blocks | 62893-20-3 | MFCD07793331 | 667.650 | C25H26N9NaO8S2 | 98.000 | [Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c2ccc(O)cc2)C(=O)C1=O | 1g | 117563896
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Medchemexpress LLC HY-B0747 100mg Medchemexpress, Eicosapentaenoic acid (ethyl ester) Ethyl eicosapentaenoate;EPA ethyl ester CAS:86227-47-6 Purity:98%
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Medchemexpress,HY-B0747 100mg Eicosapentaenoic acid (ethyl ester) Ethyl eicosapentaenoate;EPA ethyl ester CAS:86227-47-6 Formula:C22H34O2 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-B1802A 200mg Medchemexpress, Tosufloxacin (tosylate hydrate) CAS:1400591-39-0 Purity:>98%
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Medchemexpress, HY-B1802A 200mg Tosufloxacin (tosylate hydrate) CAS:1400591-39-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC RG2833 | 1215493-56-3 | 99.26% | 339.43 | 500 MG
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RG2833 is a brain-penetrant HDAC inhibitor with IC50s of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. The Ki values for HDAC1 and HDAC3 are 32 nM and 5 nM, respectively. It is for research use only.
- Brain-penetrant HDAC inhibitor.
- IC50s: 60 nM for HDAC1, 50 nM for HDAC3.
- Ki values: 32 nM for HDAC1, 5 nM for HDAC3.
- Highly active in the tested concentration range from 1 to 10 μM.
- Induces sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
- Produces significant increases in brain aconitase enzyme activity and reduces neuronal pathology of the dorsal root ganglia (DRG).
- Corrects frataxin deficiency in the brain and heart of KIKI mice.
- Improves motor coordination of YG8R FRDA mice and increases frataxin protein expression in their brain.
- Attenuates L-DOPA-induced dyskinesia in MPTP-lesioned marmosets.
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Medchemexpress LLC Isomogroside V | 1126032-65-2 | 5 MG
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Isomogroside V is a sweetener extracted from *Siraitia grosvenorii* (Swingle), also known as Monk Fruit. This product is supplied as a solid, white to off-white in appearance, with a high purity of 99.91%. It is classified as a triterpene and is used in various applications requiring a natural sweetener.
- Extracted from *Siraitia grosvenorii* (Swingle)
- Purity of 99.91%
- Solid appearance, white to off-white
- Sweetener properties
- Molecular formula C60H102O29
- Molecular weight 1287.43
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Medchemexpress LLC Acetamide, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] | 1268273-90-0 | 98.1% | 464.58 | C24H28N6O2S | 5MG
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HSP70-IN-1 is a small-molecule heat shock protein 70 (HSP70) inhibitor for research use. It inhibits growth of Kasumi-1 cells (IC50 = 2.3 μM) and HSP70-dependent functions (IC50 ≈ 1.9 μM in MOLM13 caspase assays), disrupts Hsp70-HOP-Hsp90 complex formation, impairs refolding of heat-denatured luciferase, and induces apoptosis in cancer cells.
- Inhibits HSP70 activity and HSP70-dependent cell growth.
- Demonstrated cell potency with low micromolar IC50 values.
- Interferes with chaperone complex formation and client protein stability.
- Inhibits protein refolding in cellular assays.
- Supplied as a high-purity research reagent (purity reported ~98.1%).
- Available in multiple solid and solution pack sizes for assay flexibility.
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Apexbio Technology LLC Oxcarbazepine 28721-07-5 10mg
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Oxcarbazepine (CAS 28721-07-5) is a small molecule that modulates voltage-gated sodium channels a critical target in neuronal excitability studies It impedes the association of [3H]batrachotoxin ([3H]BTX) with sodium channels demonstrating an IC50 of 160 M and restricts sodium ion influx as indicated by inhibition of 22Na uptake into rat brain synaptosomes with an IC50 of approximately 100 M These properties make oxcarbazepine valuable for investigating sodium channel function and regulation in neuropharmacology and for exploring mechanisms underlying neuronal signaling and excitotoxicity
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eMolecules 77422-99-2 | Medchem Express | PD 90780 | 5mg | 455325980 | HY-110166 | MFCD00917487 | 362.345 | C19H14N4O4
Medchem Express | PD 90780 | 5mg | 455325980 | HY-110166 | 77422-99-2 | MFCD00917487 | 362.345 | C19H14N4O4
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Medchemexpress LLC Hdac-in-4 | 1252003-13-6 | 98.0% | 335.40 g·mol-1 | C20H21N3O2 | 5 MG
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HDAC-IN-4 is a small-molecule inhibitor selective for histone deacetylase isoforms HDAC6 and HDAC10, with reported cellular activity in BRET and FRET assays and demonstrated antitumoral effects in preclinical studies. Supplied as a solid in multiple milligram sizes or as a 10 mM solution in DMSO, it is intended for research use in biochemical and cellular assays.
- Selective inhibition of HDAC6 and HDAC10.
- pIC50 values of 7.2 (HDAC6) and 6.8 (HDAC10) in BRET assays.
- Observed activity in FRET assays against several HDAC isoforms.
- Available as small solid quantities and as a 10 mM solution in DMSO.
- High purity (98.0%) suitable for biochemical assays.
- Molecular weight 335.40 g·mol-1 and formula C20H21N3O2.
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Medchemexpress LLC Rifampicin-d4 | 2747918-60-9 | 99.7% | 1 MG
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Rifampicin-d4 is a deuterium-labeled form of Rifampicin, a potent, broad-spectrum antibiotic with activity against bacterial pathogens and influenza viruses. It is intended for research use only.
- Can be used as a tracer.
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporation of deuterium allows for quantitation during drug development.
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs.
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eMolecules 1680193-80-9 | Medchem Express | JZP-361 | 5mg | 786489424 | HY-121422 | MFCD30536369 | 405.89 | C22H20ClN5O
Ambeed | 2-(tert-Butyl(2-((di-tert-butylphosphino)methyl)benzyl)phosphino)pyridine | 25mg | 649268882 | A1229869 | 2410085-45-7 | 415.542 | C25H39NP2
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