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Filtered Search Results
Medchemexpress LLC HY-30219 100mg Medchemexpress, D-(+)-Phenyllactic acid CAS:7326-19-4 Purity:>98%
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Medchemexpress, HY-30219 100mg D-(+)-Phenyllactic acid CAS:7326-19-4 D-(+)-Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Sigma Aldrich Fine Chemicals Biosciences trans-Vaccenic acid >=99% (capillary GC) | 693-72-1 | MFCD00002734 | 1G
trans-Vaccenic acid >=99% (capillary GC) | Purity: >=99% (capillary GC) | Mol Wt: 282.46 | 693-72-1 | MFCD00002734 | 1G
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Medchemexpress LLC Puromycin Dihydrochloride | 58-58-2 | MFCD00012691 | ≥98% | 544.43 | 5 ML
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Puromycin is an aminonucleoside antibiotic produced by *Streptomyces alboniger*. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. This antibiotic is capable of killing most gram-positive bacteria and various animal or insect cells.
- Inhibits protein synthesis.
- Disrupts peptide transfer on ribosomes.
- Causes premature chain termination during translation.
- Kills most gram-positive bacteria.
- Kills various animal or insect cells.
- Effective for selecting vectors bearing the pac gene in mammalian cell lines.
- Effective for selecting vectors bearing the pac gene in E. coli.
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Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 50 MG
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HS-276 is an orally active, potent, and highly selective TAK1 inhibitor. It significantly inhibits multiple kinases including TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1. This compound can be utilized for rheumatoid arthritis (RA) research, reducing the expression of TNF, IL-6, and IL-1β in a dose-dependent manner. In vivo studies have shown its effectiveness in reducing inflammation and related histological manifestations in a CIA mouse model of inflammatory arthritis.
- Potent and selective TAK1 inhibitor with a Ki of 2.5 nM
- Inhibits multiple kinases including CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1
- Reduces expression of TNF, IL-6, and IL-1β in vitro
- Effective in a CIA mouse model of inflammatory arthritis, reducing inflammation and bone damage
- Exhibits excellent bioavailability in CD-1 mice
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eMolecules BEC HCL | 222638-67-7 | MFCD03453539 | 0.25g
AstaTech | BEC HCL | 0.25g | 411869906 | 43745 | 95.000 | 222638-67-7 | MFCD03453539 | 229.480 | C5H13BClNO4S
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MEDCHEMEXPRESS LLC PYRONARIDINE TETRAPHOSPHATE 50
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501873076 PYRONARIDINE TETRAPHOSPHATE 50
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Medchemexpress LLC Elzovantinib | 2271119-26-5 | 99.9% | 409.42 | 100 MG
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Elzovantinib (TPX-0022) is an oral-active inhibitor targeting SRC, MET, and c-FMS. It effectively suppresses MET autophosphorylation and downstream signaling pathways such as STAT3, ERK, and AKT in various cell lines. In in-vivo studies, Elzovantinib has demonstrated significant tumor regression and inhibition of tumor growth without causing body weight loss.
- Oral-active inhibitor
- Targets SRC, MET, and c-FMS
- Suppresses MET autophosphorylation and downstream signaling
- Demonstrates tumor regression in animal models
- Inhibits tumor growth
- No body weight loss observed in treated mice
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377694 CCT007093 500MG
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Medchemexpress LLC HY-70037A 10mg Medchemexpress, Cinacalcet (hydrochloride) CAS:364782-34-3 Purity:>98%
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Medchemexpress, HY-70037A 10mg Cinacalcet (hydrochloride) CAS:364782-34-3 Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Selleck Chemical LLC Streptomycin sulfate S2572-50mg
Streptomycin sulfate(Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor
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Selleck Chemical LLC Geldanamycin S2713-10mM/1mL
Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1 2 M specifically disrupts glucocorticoid receptor (GR)/HSP association Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host s inflammatory responses
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Apexbio Technology LLC Nateglinide 105816-04-4 10mg
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Nateglinide (CAS 105816-04-4) is a synthetic oral antihyperglycemic agent classified within the meglitinide class It functions as an insulin secretagogue by selectively binding to pancreatic -cell ATP-dependent potassium channels resulting in membrane depolarization and subsequent stimulation of insulin release Nateglinide is widely employed in research focused on non-insulin-dependent diabetes mellitus providing a tool for investigating glucose-stimulated insulin secretion -cell responsiveness and the pharmacological modulation of insulinotropic pathways in metabolic disease models
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Apexbio Technology LLC Oxcarbazepine 28721-07-5 10mg
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Oxcarbazepine (CAS 28721-07-5) is a small molecule that modulates voltage-gated sodium channels a critical target in neuronal excitability studies It impedes the association of [3H]batrachotoxin ([3H]BTX) with sodium channels demonstrating an IC50 of 160 M and restricts sodium ion influx as indicated by inhibition of 22Na uptake into rat brain synaptosomes with an IC50 of approximately 100 M These properties make oxcarbazepine valuable for investigating sodium channel function and regulation in neuropharmacology and for exploring mechanisms underlying neuronal signaling and excitotoxicity
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Apexbio Technology LLC Lomeguatrib 192441-08-0 10mg
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Lomeguatrib (CAS 192441-08-0) is a potent inhibitor of O6-alkylguanine-DNA methyltransferase (MGMT) an enzyme involved in DNA repair that mitigates the cytotoxic effects of alkylating agents In MCF-7 cells Lomeguatrib inactivates MGMT with an approximate IC50 of 6 nM By suppressing MGMT activity Lomeguatrib sensitizes MGMT-expressing cell lines such as A375P and select mutBRAF and mutNRAS melanoma models to temozolomide but does not alter sensitivity to dacarbazine Clinical investigations have demonstrated dose-dependent inactivation of MGMT in patient-derived tumor tissues and peripheral blood mononuclear cells highlighting Lomeguatrib s value as a research tool for studying MGMT-mediated resistance mechanisms in cancer
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Apexbio Technology LLC Dapsone 80-08-0 1g
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Dapsone (80-08-0) is a small-molecule inhibitor targeting dihydropteroate synthase (DHPS) It is designed to interfere with folate synthesis pathways thereby impeding bacterial nucleic acid production Dapsone exerts its biological activity primarily through DHPS inhibition In in vitro studies dapsone demonstrates inhibitory activity with IC50 values typically ranging between 0 1 1 M dependent on organism strain and experimental conditions Based on these pharmacological properties dapsone holds research potential in leprosy drug development adjunctive antimicrobial therapy investigation antimicrobial resistance profiling and in studies targeting protozoal parasites such as Plasmodium falciparum
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