General Cell Lines and Cell Cultures
Abcam BD 1047 dihydrobromide, sigma1 receptor antagonist, 10MG
MW 437 Da, Purity >99%. Selective σ1 receptor antagonist. Shows centrally-mediated antianalgesic, antiaddictive and antidystonic effects in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AH-7614, FFA4/GPR120 antagonist, 25MG
MW 351.4 Da. Selective FFA4/GPR120 antagonist. Inhibits linoleic acid (ab141144)-induced intracellular calcium accumulation.
The product is subject to the following: Abcam Restricted Use Statement
iQ Biosciences Purified Human NK Cells, 10M cells/vial
High-quality, high-viability (> 90%) human NK cells purified from PBMCs of healthy blood donors sourced from a world-renowned blood center. Highly enriched (typically > 90%) post-selection purity achieved via magnetic isolation. All orders come with an iQ Certificate of Analysis.
Bioss KD-Validated Insulin receptor
Insulin Receptor Primary Antibody Unconjugated Public Immunogen Range 910-976/1382 Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB FCM Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
Eurofins Discoverx PathHunter HEK 293 KDR/KDR Dimerization Cell Line, 2 vials. (93-0996C1)
The PathHunter KDR/KDR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. VEGF-121) induced dimerization of KDR/KDR receptors. This product uses EFC technology. The cell line included overexpresses KDR target protein fused to PK alongside KDR target protein fused to EA. Upon ligand-induced dimerization of KDR/KDR, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter U2OS EGFR/EGFR Dimerization Cell Line, 2 vials. (93-0989C3)
The PathHunter EGFR/EGFR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. EGF) induced dimerization of EGFR/EGFR receptors. This product uses EFC technology. The cell line included overexpresses EGFR target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/EGFR, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter VIPR1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0739C3)
The PathHunter VIPR1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of VIPR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged VIPR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting VIPR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter OPRL1 Total Internalization U2OS Cell Line, 2 vials. (93-0904C3)
The PathHunter OPRL1 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of OPRL1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged OPRL1 and a ProLink-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the OPRL1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Abcam Tandospirone hydrochloride (Metanopirone), 5-HT1A partial agonist, 10MG
MW 419.9 Da, Purity >99%. Potent, selective 5-HT1A partial agonist (Ki = 27 nM). Decreases the firing rate of 5-HT neurons of the dorsal raphe. Shows anxiolytic and antidepressant effects *in vivo.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter U2OS RANK-IκB Functional Assay, 2 vials. (93-0994C3)
The PathHunter U2OS RANK-IκB Functional Assay is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the NFκB pathway. This cell line enables detection of IκB levels, allowing for assessment of NFκB pathway activation-induced IκB degradation. This product uses EFC technology. The cell line included overexpresses IκB target protein fused to ProLabel alongside untagged RANK. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of IκB EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Eurofins Discoverx PathHunter U2OS OPRM1 β-Arrestin Cell Line, 2 vials. (93-0213C3)
The PathHunter OPRM1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. met 5-enkephalin) based activation of OPRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OPRM1 and EA-tagged β-Arrestin-2. Activation of OPRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 PTGER2 β-Arrestin Cell Line, 2 vials. (93-0214C2)
The PathHunter PTGER2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGER2 and EA-tagged β-Arrestin-2. Activation of PTGER2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter HEK 293 PTGER2 β-Arrestin Cell Line, 2 vials. (93-0214C1)
The PathHunter PTGER2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGER2 and EA-tagged β-Arrestin-2. Activation of PTGER2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.