General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 NPY1R β-Arrestin Cell Line, 2 vials. (93-0397C2)
The PathHunter NPY1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged NPY1R and EA-tagged β-Arrestin-2. Activation of NPY1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 PROKR2 β-Arrestin Cell Line, 2 vials. (93-0282C2)
The PathHunter PROKR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PROKR2 and EA-tagged β-Arrestin-2. Activation of PROKR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Talaromyces varians
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
Biochain Institute Inc Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Lung, 2x10 ug/PK
BioChain's human DNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of DNA prepared from primary tumor and its adjacent normal tissue; PM consists of DNA prepared from primary tumor and corresponding ponding metastatic tumor. Genomic DNA in each pair is prepared from the same donor. This product line is designed foridentifying tumor-specific genes and tumor metastatic genes.
Eurofins Discoverx PrecisION hCav3.2 Recombinant Stable Cell Line, 2 vials. (CYL3075)
The PrecisION hCav3.2 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Cav3.2 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Cav3.2 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
ATCC Rhizobium rhizogenes
Rhizobium rhizogenes strain [CIP 104786] is a whole-genome sequenced strain that produces isoprene. This bacterium has applications in agricultural research.
Eurofins Discoverx P2RY1 Gq Calcium Signaling Cell-Based Assay Kit (1321N1)
The P2RY1 Gq Stable Cell Line Calcium Signaling Assay (1321N1) contains a stable clonal cell line used to measure P2RY1 (GPCR) activity via an increase in intracellular calcium. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx ChemiBrite EP3 Prostanoid Receptor Stable Cell Line, 2 vials. (HTS092L)
The ChemiBrite EP3 Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER3 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGER3, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PathHunter RXFP3 Total Internalization U2OS Cell Line, 2 vials. (93-0948C3)
The PathHunter RXFP3 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of RXFP3 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged RXFP3 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the RXFP3 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Staphylococcus aureus; subsp. aureus
Staphylococcus aureus subsp. aureus strain HDE288 is a methicillin-resistant bacterium that was isolated from the pneumology ward of a hospital in Lisbon, Portugal. This strain has applications in antimicrobial resistance research, drug development, and infectious disease research.
Eurofins Discoverx InCELL Hunter Jurkat RIPK1 Kinase Binding Cell Line, 2 vials. (96-0076C19)
The InCELL Hunter Jurkat RIPK1 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of RIPK1 via detection of RIPK1 levels. This product uses EFC technology. The cell line included overexpresses RIPK1 target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
ATCC MCF 10A Ecadherin; EmGFP Reporter; Breast Human
For-profit organizations: For every order of this item, you must provide a signed Material Transfer Agreement Addendum for Screening Application. We cannot ship this item until we receive this addendum. The person signing the addendum as the principal investigator must match the end user as listed on the applicable sales order for the item.Email the signed addendum to SalesPermits@atcc.org with a reference to both your account and sales order numbers. Once received, your addendum will be reviewed, and this item will be released for shipment if all requirements are met. Additional fees may apply if this product is being used for a screening use (ATCC ACS-2103F), and these fees will be applied after your order is confirmed. If you need assistance with your order, please contact our Customer Care team.