General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS FLT4 Activity Assay, 2 vials. (93-0888C3)
The PathHunter FLT4 RTK Activity cell line is a stable, engineered cell line for use in studying small molecule drug candidates targeting RTKs. This cell line enables assessment of RTK activity via detection of resulting FLT4 phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged FLT4 to the extracellular ligand binding domain of EGFR alongside an EA-tagged SH2 domain protein. Upon ligand induced receptor activation, cross-phosphorylation of the receptor leads to SH2-EA recruitment and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Rectum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Genscript Corporation CHO-K1/cyno CD155 Stable Cell
CD155 commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5) is a type I transmembrane single-span glycoprotein and belongs to the nectins and nectin-like (Necl) subfamily CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV) an etiologic agent of the central nervous system disease poliomyelitis The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells CD155 may assist in an efficient humoral immune response generated within the intestinal immune system It s been shown that CD155 can be recognized and bind by DNAM-1 and CD96 which promotes the adhension migration and NK-cell killing Thus inducing cell-mediated tumor-specific immunity
Amsbio LLC STAT1 Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
STAT1 Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Eurofins Discoverx Ready-to-Assay VPAC1 Receptor Frozen Cells, 2 Vials of Cells. (HTS043RTA)
The Ready-to-Assay VPAC1 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. VIP) based activation of VIPR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses VIPR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of VIPR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen LPA1 Lysophopholipid Receptor Stable Cell Line, 2 vials. (HTS089C)
The ChemiScreen LPA1 Lysophopholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. LPA) based activation of LPAR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PrecisION hKir2.1 Recombinant Stable Cell Line, 2 vials. (CYL3032)
The PrecisION hKir2.1 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Kir2.1 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Kir2.1 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Abcam SNC80, delta opioid receptor agonist, 10MG
MW 449.64 g/mol, Purity >99%. Highly potent and selective δ opioid receptor agonist (Ki = 9.4 nM). Centrally active following systemic administration. Displays antidepressant activity.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx Ready-to-Assay V2 Vasopressin Receptor Frozen Cells, 2 Vials of Cells. (HTS060RTA)
The Ready-to-Assay V2 Vasopressin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. vasopressin) based activation of AVPR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen FFA2/GPR43 Free Fatty Acid Receptor Stable Cell Line, 2 vials. (HTS063C)
The ChemiScreen FFA2/GPR43 Free Fatty Acid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of FFAR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay β3 Adrenergic Receptor Frozen Cells, 2 Vials of Cells. (HTS159RTA)
The Ready-to-Assay β3 Adrenergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRB3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRB3 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of ADRB3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx cAMP Hunter CHO-K1 CXCR5 Gi Cell Line, 2 vials. (95-0082C2)
The cAMP Hunter CXCR5 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL13/BCA-1/BLC) based activation of CXCR5 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CXCR5, a naturally Gi/Go coupled GPCR. Upon activation of CXCR5, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 FFAR3 (GPR41) Gi Cell Line, 2 vials. (95-0136C2)
The cAMP Hunter FFAR3 (GPR41) Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. FFAs) based activation of FFAR3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FFAR3, a naturally Gi/Go coupled GPCR. Upon activation of FFAR3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PrecisION hnAChR α4/β2 Recombinant Stable Cell Line, 2 vials. (CYL3106)
The PrecisION hnAChR α4/β2 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying nAChR α4/β2 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses nAChR α4/β2 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
