General Cell Lines and Cell Cultures
Eurofins Discoverx cAMP Hunter CHO-K1 SSTR2 Gi Cell Line, 2 vials. (95-0095C2)
The cAMP Hunter SSTR2 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin 28) based activation of SSTR2 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type SSTR2, a naturally Gi/Go coupled GPCR. Upon activation of SSTR2, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen CRF2 Receptor Stable Cell Line, 2 vials. (HTS024C)
The ChemiScreen CRF2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CRH, sauvagine) based activation of CRHR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CRHR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CRHR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay CysLT1 Leukotriene Receptor Frozen Cells, 2 Vials of Cells. (HTS061RTA)
The Ready-to-Assay CysLT1 Leukotriene Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. leukotriene) based activation of CysLT1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CysLT1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CysLT1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay CB2 Cannabinoid Receptor Frozen Cells, 2 Vials of Cells. (HTS020RTA)
The Ready-to-Assay CB2 Cannabinoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. adrenocorticotropin) based activation of CNR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CNR2 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CNR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay XCR1 Chemokine Receptor Frozen Cells, 2 Vials of Cells. (HTS053RTA)
The Ready-to-Assay XCR1 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. lymphotactin) based activation of XCR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses XCR1 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of XCR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen CXCR2 Receptor Membrane Preparation, 1 vial. (HTS002M)
The ChemiScreen CXCR2 Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CXCR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay A2A Adenosine Receptor Frozen Cells, 2 Vials of Cells. (HTS048LRTA)
The Ready-to-Assay A2A Adenosine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. adenosine, NECA) based activation of ADORA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADORA2A alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of ADORA2A, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen VPAC2 Receptor Membrane Preparation, 1 vial. (HTS079M)
The ChemiScreen VPAC2 Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of VIPR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen NTR1 Neurotensin Receptor Membrane Preparation, 1 vial. (HTS034M)
The ChemiScreen NTR1 Neurotensin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of NTSR1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay APJ Apelin Receptor Frozen Cells, 2 Vials of Cells. (HTS068RTA)
The Ready-to-Assay APJ Apelin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. apelin) based activation of AGTRL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AGTRL1 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AGTRL1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen BB3 Bombesin Receptor Membrane Preparation, 1 vial. (HTS160M)
The ChemiScreen BB3 Bombesin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of BRS3 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay 5-HT2A Serotonin Receptor Frozen Cells, 2 Vials of Cells. (HTS082RTA)
The Ready-to-Assay 5-HT2A Serotonin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. serotonin/5-HT) based activation of HTR2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HTR2A alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of HTR2A, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen SST3 Somatostatin Receptor Membrane Preparation, 1 vial. (HTS171M)
The ChemiScreen SST3 Somatostatin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of SSTR3 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Innovative Research Inc Single Donor Human Semen 5ml
Single Donor Human Semen from Innovative Research is collected from a unique single donor in an FDA-approved facility, and processed using ISO-approved procedures.
Innovative Research Inc Pooled Human Saliva 5ml
Pooled Human Saliva from Innovative Research is collected fresh from two or more donors, pooled, and stored frozen. Produced in the salivary glands, human saliva is 99.5% water, but contains many important substances including electrolytes, mucus, antibacterial compounds, and various enzymes.