Sera
Cayman Chemical NItazoxnIde 100mg
A prodrug form of tizoxanide; inhibits C. parvum growth in MDBK cells at 10 UG/ml; active against M. tuberculosis and M. bovis (MIC = 16 UG/ml for both); inhibits SARS-CoV-2 and MERS-CoV replication at 5 and 10 µM; inhibits replication of H1N1 PR8 and WSN, as well as H5N9 A/Ck viruses (EC50s = 1, 0.5, and 1 UG/ml, respectively); reduces oocyst shedding and parasite burden, but not the severity of diarrhea, in a gnotobiotic piglet model of C. parvum infection at 250 mg/kg
Cayman Chemical Fludarabn 50mg
An intermediate active metabolite of fludarabine phosphate; inhibits the proliferation of RPMI-8226, MM.1S, and MM.1R multiple myeloma cells (IC50s = 1.54, 13.48, and 33.79 µM, respectively); increases Bax levels and decreases Bid, XIAP, and survivin levels, in RPMI-8226 cells at 2 UG/ml; an inhibitor of SARS-CoV-2 RdRp (EC50 = 1.06 µM); completely inhibits DNA synthesis in an SA-NH murine sarcoma model at 200 mg/kg; reduces tumor growth in an RPMI-8226 mouse xenograft model at 40 mg/kg; reduces tumor growth in an L1210 murine leukemia model
Cayman Chemical SR 58611AhydrochlorIde 10mg
A selective β3-AR agonist (EC50 = 3.5 nM in rat colon); minimally active against β1-ARs in rat uterus (EC50 = 499 nM) and inactive against β2-ARs in guinea pig trachea and atrium (EC50s = >10,000 and >30,000 nM, respectively); activates brown fat metabolism through activation of adenylyl cyclase activity and glycerol release in brown adipocytes (EC50s = 20 and 11 nM, respectively); reduces hypothermia produced by apomorphine and reserpine; potentiates toxicity produced by yohimbine; reduces number of escape failures in a learned helplessness model of antidepressant-like activity in rats
Cayman Chemical NRG-3hydrochlorIde 50mg
A substituted cathinone that is structurally analogous to pentylone, with the methylenedioxy group replaced with a naphthyl group
Cayman Chemical 4-HydroxyIsoleucIn 50mg
An amino acid with antidiabetic activity; increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas at 200 μM; increases PI3K activity in muscle and liver in rats at 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and STZ at 25 mg/kg; decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes at 50 mg/kg per day for four weeks
Cayman Chemical LOMEGUATRIB 50MG
A modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM)
Cayman Chemical MemntInhydrochlorIde 50mg
An NMDA receptor antagonist; blocks NMDA-induced currents in rat retinal ganglion cells by 90% at 12 μM; reverses I1PP2A-induced inhibition of dephosphorylation of tau194-207 in vitro; restores PP2A activity, decreases GSK-3β and Aβ levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer's disease at 2 mg/kg; reduces responding on the ethanol-associated lever in a cue-induced ethanol seeking test in rats at 20 mg/kg; decreases secretion of MMP-9, degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia
Cayman Chemical INCB 3284dImesylate 50mg
A potent, selective, and orally bioavailable antagonist of MCP-1 binding to CCR2 (IC50 = 3.7 nM); inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees
Cayman Chemical 2-PhenthylamInhydrochlorI 50mg
A natural monoamine alkaloid that acts as neuromodulator in the central nervous system; stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes; intended for forensic and research applications
Cayman Chemical SalbutamolhydrochlorIde 50mg
A β2-AR agonist; induces relaxation of isolated guinea pig tracheal chains (EC50 = 16 nM); selectively binds to the β2-AR over the β1-AR (Kds = 0.236 and 1.54 µM, respectively); nebulized (R)-salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (ED50 = 39.7 μg/animal)
Cayman Chemical UmbelIferon 100mg
A derivative and metabolite of coumarin with diverse biological activities; inhibits growth of human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells at 250-300 UG/ml; increases ROS production and halts the cell cycle in KB human oral carcinoma cells; has antidepressant-like activity in a rat model of depression induced by chronic unpredictable mild stress at 15 and 30 mg/kg; used as a ratiometric pH indicator with ex/em = 330 and 370/460 nm at low and high pH, respectively
Cayman Chemical PalmItoylLcarnItInchLRI 50mg
A long-chain acylcarnitine; delivers palmitate into the mitochondria for fatty acid oxidation and energy production; inhibits lecithin:cholesterol acyltransferase activity in isolated rat plasma at 500 µM; serum and hepatic levels are increased in mice during cold exposure; protects against age-induced cold sensitivity in mice
Cayman Chemical AdenosIn 3-monphosphates 50mg
A nucleotide and metabolite; formed via hydrolysis of 2',3'-cAMP by metal-dependent phosphodiesterases; reduces proliferation of rat PGVSMCs and GMCs; metabolic intermediate in the biosynthesis of adenosine
Cayman Chemical FlavopIrIdol 50mg
An inhibitor of cyclin-dependent kinases (Cdks; IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively); inhibits TEFb (Ki = 3 nM); inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK293T cells (IC50 = <10 nM); induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model at 5 mg/kg; suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis
Sino Biological Recombinant Cynomolgus NEK7 Protein (full length, GST Tag)
Recombinant full-length monkey NEK7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.