Sera
Cayman Chemical PerIndoprIl 100mg
An orally active ACE inhibitor that effectively lowers blood pressure; metabolized to perindoprilat, a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro)
Cayman Chemical TIloronhydrochlorIde 50mg
An orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions
Cayman Chemical TroglItazon 50mg
A selective agonist of PPARγ (EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay); selective for PPARγ over PPARα and PPARδ, at which it is inactive at ≤10 μM; exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively, at 500 mg/kg twice per day; induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells at 10 μM and increases apoptosis in these cells at ≥30 μM
Cayman Chemical Nmethyl Perfluoroctnsulfo 50mg
A perfluoroalkyl substance; has been found in landfill leachate
Cayman Chemical VImseltInIb 50mg
An inhibitor of CSF1R (IC50 = 3.7 nM); selective for CSF1R over FLT3, PDGFRα, PDGFRβ, and KIT (IC50s = >3,300, 436, 2,300, and 476 nM, respectively; inhibits the proliferation of M-NFS-60 cells (IC50 = 18 nM); inhibits CSF1-induced CFS1R autophosphorylation in THP-1 cells (IC50 = 27 nM) and CSF1- and RANKL-induced osteoclast differentiation (IC50 = 9.3 nM)
Cayman Chemical Daclatsvr 50mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical SureLIghtPerCP CynIn 5 5 100mg
SureLight™ PerCP Cyanine 5.5 is a fluorescent probe used in protein detection Excitation max. λ: 496 nm Emission max. λ: 517 nm Uses: Custom antibody labeling, fluorescence-activated cell sorting, flow cytometry, Luminex, and T cell labeling
Cayman Chemical LevobetaxololhydroCLOrID 100mg
A β1-adrenergic receptor antagonist (Ki = 0.76 nM for the human receptor); selective for β1-ARs over β2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM); inhibits isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM); topical application reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension at 150 UG/eye
Cayman Chemical PleuromutIlIn 50mg
An antibiotic that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation
Cayman Chemical NaftIfInhydrochlorIde 100mg
Blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase (Ki = 1.1 µM for C. albicans epoxidase)
Cayman Chemical 7-MethylxnthIn 100mg
An adenosine A1 receptor antagonist and active metabolite of theobromine and caffeine; inhibits binding of cyclohexyladensoine in rat cerebral cortical membranes; inhibits eye elongation and reduces decreases in the diameter of scleral collagen fibrils in a guinea pig model of form-deprivation myopia at 300 mg/kg
Cayman Chemical FloxurIdIn 100mg
An active metabolite of 5-fluorouracil; induces DNA double-strand breaks in thymidylate synthase-deficient FM3A cells, as well as increases dATP levels and decreases dTTP and dGTP levels in wild-type thymidylate synthase-expressing FM3A F28-7 cells at 1 µM; inhibits the proliferation of L1210 and HeLa cells (IC50s = 1.1 and 9.4 nM, respectively); reduces tumor growth by 86.3% in a S180 murine sarcoma model at 200 mg/kg, i.p.
Cayman Chemical SInomenInhydrochlorIde 100mg
A natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis; activates histamine release, reduces joint stiffness and pain, and alters cytokine generation; impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain
