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A phosphatidylcholine; increases IL-1β production in isolated human blood monocytes at 12.5 µM; plasma levels are decreased in patients with lung cancer
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively); less effectively inhibits a wide variety of related or common kinases; disrupts circadian rhythms in cells and animals; blocks the locomotor response to amphetamines in mice
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A non-depolarizing muscle relaxant that competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An endogenous nucleotide sugar that binds the P2Y14 receptor (EC50 = 0.35 μM) as well as GPR17; induces oligodendrocyte differentiation at a maximal concentration of 100 μM
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A SUR1/Kir6.2 channel inhibitor (IC50 = 4.9 µM); selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively); increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets; reduces blood glucose levels in a mouse model of STZ-induced diabetes at 80 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An inhibitor of SGLT2 (IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM); lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More