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A demethylated variant of necrostatin-1 that inhibits IDO; ~ 100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent than Nec-1 in a mouse necroptosis assay; inhibits TNF-induced systemic inflammatory response syndrome in vivo
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A demethylated variant of necrostatin-1 that inhibits IDO; ~ 100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent than Nec-1 in a mouse necroptosis assay; inhibits TNF-induced systemic inflammatory response syndrome in vivo
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A melatonin receptor agonist (Kis = 0.14 and 0.41 nM for MT1 and MT2, respectively) and 5-HT2B and 5-HT2C antagonist (Kis = 0.26 and 0.71 nM, respectively); inhibits the 5-HT2-mediated penile erection response in rats at 40 mg/kg; increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats at 20-80 mg/kg; reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice in a transgenic neuroendocrine model of depression at 10 mg/kg
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There are five immunoglobulin classes in humans. Out of these immunoglobulin M (IgM) is a high molecular weight protein that has five or six subunits. IgM monomers are made of two heavy chains and two light chains connected by a disulfide bond. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.IgM antibodies are present as pentamers in the serum and are produced in response to antigens.IgM from human serum is purified from normal human serum by precipitation and gel filtration techniques. The immunoglobulin is determined to be atleast 95% pure by HPLC procedures.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A natural demethoxy derivative of curcumin; activates macrophage phagocytosis and, with 1α,25-dihydroxy vitamin D3, stimulates amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC); suppresses proliferation in cancer cells; down-regulates p300 and inhibits LPS-induced iNOS expression
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Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. A immunoglobulin has two heavy chains and two light chains connected by a disulfide bond. It mainly helps in immune defense. It is a glycoprotein. IgG is a major class of immunoglobulin. Mouse consists of five immunoglobulin classes- IgM IgG IgA IgD and IgE. Mouse IgG is further divided into five classes- IgG1 IgG2a IgG2b and IgG3.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A DPP-4 inhibitor (IC50 = 18 nM); selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases; improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well as ob/ob and high-fat diet fed mice; reduces hyperglycemia in mice fed a high-fat diet with streptozotocin-induced diabetes
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Horse serum produced from adult horses is homogenous and has low levels of polyamine oxidase. It is metabolically stable and promotes cell proliferation. Horse sera is an alternate to bovine serum and is a source of growth factors and hormones.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More