Sera
Cayman Chemical ProstaglndIn F2a 50mg
A widely distributed primary PG occuring in many species; causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity
Cayman Chemical 1Oleoyl2hydroxysnglycero 50mg
1-Oleoyl-2-hydroxy-sn-glycero-3-PA is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase.{2656} Hydrolysis of the fatty acid at the sn-2 position by PLA2 yields bioactive LPA. LPA binds to one of four different G-protein linked receptors{13001} to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.{2656} 1-Oleoyl-2-hydroxy-sn-glycero-3-PA is the most potent of the LPA analogs for calcium mobilization in A431 cells{2665} and for growth stimulation of a variety of cell lines.{2666}
Cayman Chemical RImntadInhydrochlorIde 50mg
A derivative of amantadine with antiviral activity; inhibits recombinant influenza A M2 protein expressed in X. laevis oocytes (IC50 = 10.8 µM); inhibits recombinant HCV p7 protein expressed in HEK293 cells (IC50s = 0.7, 24, 1.6, and 3.0 nM for HCV genotypes 1a, 2a, 3a, and 4a, respectively); inhibits cytotoxicity induced by the influenza A strains A/PR/8/34 (H1N1) and A/HK/7/87 (H3N2), but not the influenza B strain B/HK/72, in MDCK cells (EC50s = 18, 0.62, and >500 µM, respectively); increases the survival rate of mice infected with the influenza A strain infected with the influenza A strain A2/Jap/305 from 20 to 90% at 24 mg/kg when administered two hours post-infection; has trypanocidal activity against bloodstream forms of T. brucei in vitro (IC50 = 1.26 UG/ml)
Cayman Chemical RamoplnIn Complex 100mg
An antibiotic complex; active against clinical isolates of S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 UG/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 UG/ml); inhibits cell wall synthesis in B. subtilis at 0.5 UG/ml; effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice (ED50s = 0.081, 0.14, and ~25 mg/kg per day, respectively)
Cayman Chemical CortIcosteron 100mg
A steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors; also is the precursor to aldosterone synthesis
Cayman Chemical ElIptIcInhydrochlorIde 50mg
A DNA-intercalating antitumor agent that forms covalent adducts in DNA after being enzymatically activated with CYP3A4, CYP1A1, or CYP1A2 or by peroxidases in target tissues; inhibits the proliferation of human breast adenocarcinoma, leukemia, neuroblastoma, and glioblastoma cells (IC50s = 0.27-4.7 µM)
Cayman Chemical IndocynIn Green 100mg
A vital fluorescent dye; binds to plasma proteins and lipoproteins; ex/em = 750-800/≥800 nm, respectively, with emission maximum shifting from 810-820 nm in aqueous solution to 820-834 nm following intravenous injection
Cayman Chemical Coydals ynusuo Coydaln 100mg
An alkaloid with diverse biological activities; inhibits AChE (IC50 = 15 μM); nematocidal against S. ratti and S. venezuelensis third instar larvae (PC50s = 18 and 30 μM, respectively); inhibits thrombin-induced platelet aggregation in vitro (IC50 = 54.16 μg/ml); increases gastric emptying in rat models of apomorphine- and laparotomy-induced delayed gastric emptying at 1 and 3 mg/kg
Cayman Chemical TamInadent 50mg
An adenosine A2A receptor antagonist (Ki = 12 nM); selective for adenosine A2A receptors over adenosine A1-, A2B-, and A3 receptors (Kis = 2,500, 1,000, and 5,000 nM, respectively); increases the levels of IFN-γ secreted by tumor-associated T cells isolated from patient-derived lung tumors at 1 µM when used in combination with an antibody targeting PD-1 or PD-L1; reduces the number of lung nodules in an MCA-205 murine fibrosarcoma model of lung metastasis at 15 mg/kg per day; inhibits haloperidol-induced catalepsy in a rat model of Parkinson's disease motor symptoms at 3, 10, or 30 mg/kg
Cayman Chemical Fructose1 6bIsphosphatse1 50mg
A cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity by competing at the AMP allosteric binding site (IC50 = 3.4 µM; Ki = 1.1 µM); blocks glucose production in starved rat hepatoma cells (IC50 = 6.6 µM)
Cayman Chemical CefazolInsodIum salt 100mg
A cephalosporin antibiotic; active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml); inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml); protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively)
Cayman Chemical CefmenoxImehydrochlorIde 100mg
A cephalosporin antibiotic; active against clinical isolates of S. aureus, S. epidermidis, S. pyogenes, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. marcescens, and E. cloacae in vitro (MICs = 0.013-6.25 μg/ml); active against various Gram-positive and Gram-negative bacterial infections in mice (ED50s = 0.016-66 mg/kg); increases survival in a mouse model of K. pneumoniae infection (SD50 = 7.6 mg/kg); curative in a mouse model of P. mirabilis urinary tract infection (CD50s = 0.4-0.75 mg/kg)
Cayman Chemical Hexaconazole 50mg
A triazole fungicide; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; curative against powdery mildew on barley plants at 6.7 mg/L; improves water, proline, and protein contents as well as increases non-enzymatic and enzymatic antioxidant and apigenin-7-glucoside content in M. chamomilla plants during a water deficit stress tolerance test at 15 mg/L; inhibits the differentiation of mouse embryonic stem cells into cardiomyocytes (EC50 = 16.6 μM); induces bone morphological defects in mouse fetuses
Cayman Chemical ClIndamycIn 100mg
A lincosamide antibiotic; active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 UG/ml, respectively); active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively); inhibits bacterial protein synthesis by interacting with the 50S ribosome; increases survival in a mouse model of a secondary S. pneumoniae infection at 15 mg/kg twice daily for seven days
Cayman Chemical 3 4-EDMAhydrochlorIde 50mg
An analog of 3,4-MDMA that stimulates the release of serotonin and dopamine from rat brain synaptosomes at 1 µM