Sera
Cayman Chemical Setpprnt 50mg
An orally bioavailable antagonist of CRTH2/DP2 (IC50 = 6 nM for the human receptor); selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and EP2 and EP4 in a β-arrestin assay (IC50s = 2,600 and >10,000 nM, respectively); inhibits PGD2-induced calcium flux in HEK293 cells expressing human CRTH2/DP2 (IC50 = 30 nM); inhibits PGD2-induced shape change in human eosinophils (IC50 = 235 nM)
Cayman Chemical THIAMETHOXAM 100MG
A neonicotinoid insecticide and a prodrug form of clothianidin; binds to nAChRs with low affinity (IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro; leaf or drench application of thiamethoxam reduces the number of aphids on potato plants in field studies at 100 or 200 mg/L; induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays at 200 mg/L
Cayman Chemical IsoxnthopterIn 100mg
A natural intermediate in the pteridine pathway that can be produced naturally from 7-oxobiopterin or in vitro by the oxidation of pterin by xanthine oxidase
Cayman Chemical Phenndon 50mg
An anticoagulant and vitamin K antagonist; inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in liver homogenates in a concentration-dependent manner; inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively, at 0.5 mg/100 g; dietary administration inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively, at 4 mg/kg per day
Cayman Chemical Nmethyl Perfluoroctnsulfo 50mg
A perfluoroalkyl substance; has been found in landfill leachate
Cayman Chemical 1OHexadecylsnglycerol 100mg
An alkyl glyceryl ether; reduces UVB-induced cell death and production of ROS and PGE2 in NHEKs; increases coronary flow and left ventricular developed pressure and reduces MDA formation ex vivo in a rat heart model of ischemia/reperfusion injury
Cayman Chemical N4-MethylcytIdIn 50mg
A pyrimidine nucleoside and derivative of cytidine; found in mammalian mitochondrial rRNA where it stabilizes the structure of 12S rRNA and is essential for mitochondrial translation of oxidative phosphorylation-related proteins; maintains normal base pairing with guanine in RNA oligomers
Cayman Chemical DrospIrenon 100mg
A synthetic progestogen; binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone, and R1881, respectively; inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day); maintains pregnancy in ovariectomized pregnant rats; reduces serum testosterone and luteinizing hormone in cynomolgus monkeys; inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats
Cayman Chemical CJC-1295acetate 100mg
A synthetic peptide derivative of GHRH; does not contain a DAC moiety, which reduces its half-life; increases the secretion of growth hormone in primary rat anterior pituitary cells when used from pM to µM concentrations; increases the secretion of growth hormone into rat blood at 1 µmol/kg, s.c.
Cayman Chemical 6aMethylprednIsoLN 21acet 50mg
A synthetic glucocorticoid and an ester form of methylprednisolone; reduces IL-1β-induced production of PGE2 and increases in MMP-13 levels in equine osteochondral and synovial explant cocultures from 1-100 nM; intramuscular injection induces retinal lipid peroxidation and apoptosis in rabbits at 20 mg/kg
Cayman Chemical Cyprus rotundus aCypron 50mg
A sesquiterpenoid with diverse biological activities; inhibits LPS-induced nuclear translocation of p65, as well as LPS-induced production of PGE2 and IL-6, in RAW 264.7 cells; reduces hydrogen peroxide-induced production of ROS and apoptosis in SH-SY5Y cells at 15 and 30 µM; reduces the production of HBsAG in infected HepG2.2.15 cells (IC50 = 274.7 µM)
Cayman Chemical ValrocemIde 100mg
An anticonvulsant; protects against MES-, PTZ-, picrotoxin-, or bicuculline-induced seizures in mice (ED50s = 151, 132, 275, and 248 mg/kg, respectively); prevents sound-induced seizures in Frings audiogenic-sensitive mice (ED50 = 52 mg/kg) and MES-induced seizures in rats (ED50 = 73 mg/kg); prevents seizures in corneally kindled rats (ED50 = 161 mg/kg)
Cayman Chemical VIlazodonhydrochlorIde 50mg
An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM, respectively); increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex at 1 and 3 mg/kg, i.p.; decreases immobility in the forced swim test in both rats and mice at 1 mg/kg