Sera
Cayman Chemical MoguIsteIn 100mg
A peripherally acting antitussive agent; inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively); prevents BALF eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation; inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs at 30 mg/kg
Cayman Chemical SRT 3025hydrochlorIde 50mg
A SIRT1 activator; increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse BMDMs at 2 µM; inhibits proliferation of SU.86.86 cells (IC50 = 0.98 µM); decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet at 3.18 g/kg
Cayman Chemical DoxazosInmesylate 100mg
An α1-AR antagonist (Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively); inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips (pA2s = 8.8 and 8.2, respectively); inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both)
Cayman Chemical CarbIdopahydrate 100mg
A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo
Cayman Chemical 4NItrophenyl DXylopyrnos 100mg
A chromogenic β-xylosidase substrate; upon hydrolysis by β-xylosidase, 4-nitrophenol is released, which can be quantified by colorimetric detection at 405 nm as a measure of β-xylosidase activity
Cayman Chemical ImeglImInhydrochlorIde 50mg
An anti-hyperglycemic compound; inhibits high-glucose- or tert-butyl hydroperoxide-induced cell death in HMEC-1 cells at 100 µM; reduces tert-butyl hydroperoxide-induced cytochrome c levels, as well as mitochondrial membrane permeability without affecting mitochondrial respiration, in HMEC-1 cells at 100 µM; decreases plasma glucose levels and increases plasma insulin levels in a rat model of high-fat diet-induced obesity at 150 mg/kg in the diet; reduces colonic balloon-induced pain-related muscle contractions in rats at 100 mg/kg; reduces colonic hyperpermeability in a rat model of LPS-induced IBS at 100 mg/kg
Cayman Chemical MonacylglycRol lpase InHB 50mg
Selectively and reversibly blocks MAGL activity (IC50s = 0.18 and 59 µM for MAGL and FAAH in mouse brain, respectively); does not inhibit ABHD6, ABHD12, CB1, or CB2 receptors (Kis > 10 µM); used to ameliorate disease progression in a mouse model of multiple sclerosis
Cayman Chemical 2-PhenthylamInhydrochlorI 50mg
A natural monoamine alkaloid that acts as neuromodulator in the central nervous system; stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes; intended for forensic and research applications
Cayman Chemical 4fluoroaPyrroldInopentIop 50mg
An isomer of α-PVP characterized by the addition of a fluorine group at the 4 position of the phenyl ring; intended for forensic and research applications
Cayman Chemical nastrozole 50mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical Bcuculn 100mg
A competitive GABAA receptor antagonist that at 100 μM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons; reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 = 1.7 μM); mimics the action of epilepsy and thus used in experimental studies as a convulsant
Cayman Chemical OseltamIvIrphosphate 100mg
An antiviral prodrug targeted against the influenza viruses; once hydrolyzed to its active metabolite, it can competitively inhibit viral neuraminidase (IC50s = 0.1-4.9 nM for influenza neuraminidases A and B)
