Whole blood cells suitable for use in complement titration, adsorption procedures, testing for agglutinins/HA assays, and the preparation of stroma as particulate reagents.
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A chiral building block has been used in the synthesis of a chiral synthetic antibiotic intermediate as well as in the stereoselective synthesis of NK receptor antagonists
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A muscarinic receptor antagonist (Kis 1.62 27.5 and 2.63 nM for M1 M2 and M3 receptors respectively) inhibits carbachol-induced contraction of isolated human iris sphincter circular ciliary muscle and longitudinal ciliary muscle (Kbs 7.9 15.8 and 12.5 nM respectively)
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An ectoparasiticide and antipruritic agent blocks mouse TRPV4 channel expressed in HEK293 cells in a calcium-dependent manner (IC50s 223.5 and 15.5 M in buffer containing 0 and 2 mM calcium respectively) inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A topical application inhibits scratching behavior in mice induced by histamine serotonin and the PAR2 agonist SLIGRL-NH2 (0.025 g of a 10 ointment)
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A fluorescent cationic dye ex/em spectra 502/525 460/650 and 475/590 nm when bound to dsDNA bound to ssDNA or RNA and under acidic conditions respectively ratio of emission at 590 to emission at 525 nm can be used to quantify the increase in acidic vesicular organelles observed during cellular autophagy
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A biotinylated form of DEPMPO which is used to spin trap reactive O- N- S- and C-centered radicals offers monitored biodistribution in cells tissues and organs when used with an avidin-conjugated reporter binds free radicals on proteins producing adducts that can be analyzed via the biotin tag.
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Immunogen Synthetic peptide from the N-terminal region of the a3 subunit of the rat GABAA receptor Host Rabbit Species Reactivity ( ) Mouse Rat Applications IHC WB MW 51 kDa
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