Guinea Pig Whole Blood
Cayman Chemical DotrIacontnoIc ACD methyl50mg
A muscarinic receptor antagonist (Kis 1.62 27.5 and 2.63 nM for M1 M2 and M3 receptors respectively) inhibits carbachol-induced contraction of isolated human iris sphincter circular ciliary muscle and longitudinal ciliary muscle (Kbs 7.9 15.8 and 12.5 nM respectively)
Cayman Chemical TaurohyodeoxycholIc ACD MaxS
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser187 of rat SNAP-25 Host Rabbit Species Reactivity ( ) Mouse Rat Applications WB MW 25 kDa
Cayman Chemical 2Hydroxy Faty ACD Methyl10mg
An adenosine A2B receptor antagonist (Ki 53.4 nM) selective for A2B over A1 and A2A receptors which have Ki values of 2200 and 24000 nM respectively selective for A2B over the A3 receptor which is inhibited only 14 at a concentration of 10 UM pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical 3 3SulfInyldIpropnoIc ACD
A peptide substrate for PKC selective for PKC over PKA CK1 CK2 phosphorylase kinase and CaMKII has been used to monitor PKC activity in primary human renal artery smooth muscle cells
Cayman Chemical TrIcosnoIc ACD methyl STR
A vasoconstrictor increases cardiac output mean arterial pressure and coronary blood flow and decreases pulse rate in a canine model of cardiogenic shock when administered at a dose of 0.05 mg/kg increases survival in a canine model of hemorrhagic hypotension reverses acetoxycycloheximide-induced transient amnesia in a shock avoidance test in rats
Cayman Chemical 5MethoxyIndole3ACtIc ACD 500mg
A phospholipid has been used in the formation of PERLs that reduce cellular cholesterol levels in human PMBCs and decrease the secretion of HIV-1 particles in PBMCs infected with HIV-1LAI has been used as a component of lipid monolayers and small unilamellar vesicles to study the effect of phospholipid composition on membrane fluidity
Cayman Chemical 3AmInopropylphosphonIc ACD
A chromone complex that acts as a mast cell stabilizer to prevent the release of histamine
Cayman Chemical LIgnocRIc ACD methyl STR 250mg
An inhibitor of lysosomal acid lipase (IC50 68 nM) selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 UM reduces cholesterol accumulation in lysosome-like storage organelles in NPC1-deficient GM03123 cells (0.01-10 UM)
Cayman Chemical 3 3DIthIodIpropIonIc ACD d
A microbial metabolite active against B. subtilis K. rhizophila and S. aureus (MICs 4 8 and 4 g/ml respectively) and T. mentagrophytes and T. rubrum (MIC 25 Ug/ml for both)
Cayman Chemical trnsVaccenIc ACD methyl S
A histamine H1 receptor antagonist (Ki 2.3 nM) and first generation antihistamine competes with [3H]diltiazem for binding to the benzothiazepine site on rat cardiomyocytes (Ki 1.08 nM) decreases negative inotropic activity in isolated guinea pig left atria by 76 (EC50 250 nM) decreases negative chronotropic activity in guinea pig spontaneously beating isolated right atria by 48
Cayman Chemical ArachIdonIc ACD 1 2 3 4 513
A pan Akt inhibitor (Ki 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Cayman Chemical GlycoursodeoxycholIc ACD 250mg
A P-gp inhibitor inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 0 05 UM) inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s 73 and 9 3 UM respectively) enhances growth inhibition of MCF-7/ADR breast cancer cells at 2 or 20 UM when used in combination with doxorubicin in vitro but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 UM
Cayman Chemical VIldaglIptIn carboxylIc ACD
An inhibitor of VEGFR2 (IC50 0 0027 M for the human receptor) selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s 1 5 1 7 and 1 1 M respectively) as well as 40-fold selective over B-RAF RET and Tie2 inhibits VEGF-induced proliferation of HUVECs (IC50 0 01 nM) inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice at 1 and 3 mg/kg per day inhibits primary tumor and metastasis growth in a B16 melanoma mouse model at 3 mg/kg per day
Cayman Chemical RCS4 NpentnoIc ACD metabo
Antigen recombinant mouse ANGPTL3 Host Rat Cross Reactivity ( ) Mouse ANGPTL3 ( ) mouse ANGPTL4 and human ANGPTL3 Application(s) ELISA and WB ANGPTL3 regulates angiogenesis and also directly regulates lipid glucose and energy metabolism
Cayman Chemical DocosahexaenoIc ACD ethyl S
An imidazoline receptor agonist selectively binds to imidazoline I1 and -I2 receptors over a2-ARs (IC50s 0.034 0.026 and 15 UM respectively) reduces complete Freund’s adjuvant-induced thermal and mechanical hyperalgesia in rats at 10 or 17.8 mg/kg decreases the latency to seizure onset and increases the percentage of animals with grade V seizures to a greater extent in female than male mice reverses cognitive deficits in the 5XFAD transgenic mouse model of Alzheimer’s disease at 5 mg/kg