Human Sera
Cayman Chemical 2-CMethylgunosIn 50mg
A covalent BTK inhibitor (IC50 0 1 nM) 5000-fold selective for BTK over a panel of 240 kinases but does inhibit TEC BMX and TMX (IC50s 0 9 1 5 and 5 0 nM respectively) inhibits BCR stimulation-induced calcium flux in Ramos B cells (IC50 7 2 nM) as well as BCR stimulation-induced proliferation of and CD86 surface expression in peripheral B cells (IC50s 0 04 and 0 3 nM respectively) inhibits FcY receptor stimulation-induced TNF-a production in human PBMCs (IC50 0 3 nM) completely protective against bone destruction in a mouse model of collagen-induced arthritis at 0 5 mg/kg reduces proteinuria and glomerular IgG immune complex deposition and increases survival in an NZB/W lupus-prone mouse model
Cayman Chemical Lnsoprazole sulfon NoxIde 50mg
A terpenoid with diverse biological activities activates TRPV3 currents in HEK293 cells expressing mouse or human TRPV3 at 500 UM active against a variety of plant pathogenic fungi (MICs 100-300 Ug/ml) active against E coli and S aureus (MIC 500 Ug/ml for both) inhibits lipid peroxidation in ox brain phospholipid liposomes by 45-82 at 0 067-0 664 mM reduces inflammatory cell infiltration into the airway decreases the levels of IL-4 IL-5 and IL-13 in BALF and prevents airway hyperresponsiveness in a mouse model of ovalbumin-induced allergic asthma at 16 mg/kg
Sigma Aldrich Fine Chemicals Biosciences SigMatrix Ultra Serum Dilu
for more information on other Sigmatrix products visit the Sigmatrix Selection Guide.
Sigma Aldrich Fine Chemicals Biosciences IgM from human serum reage25MG
There are five immunoglobulin classes in humans. Out of these immunoglobulin M (IgM) is a high molecular weight protein that has five or six subunits. IgM monomers are made of two heavy chains and two light chains connected by a disulfide bond. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.IgM antibodies are present as pentamers in the serum and are produced in response to antigens.IgM from human serum is purified from normal human serum by precipitation and gel filtration techniques. The immunoglobulin is determined to be atleast 95% pure by HPLC procedures.
Sigma Aldrich Fine Chemicals Biosciences 6 SigMatrix Serum diluent1L
This reagent is a 6% recombinant HSA (Human Serum Albumin) in PBS SOLUTIONon pH 7.4 that can be used as a blank or matrix/diluent for proteinaceous analytes in LC-MS/MS calibrators controls or samples.The 6% protein content design is meant to mimic endogenous protein concentration in human serum samples.Beneficially as the HSA source is recombinant the matrix should not contain any measurable contaminants typically found in even stripped serum.
Cayman Chemical TRAP6 amIdetrIfluoroACTAt 50mg
An inhibitor of Mre11 endonuclease activity decreases the number of chromosomal breaks in 1BR3 fibroblasts induced by knockdown of BRCA2 reduces homologous recombination-mediated DNA repair in DR-GFP U2OS cells and enhances DNA repair mediated by NHEJ in H1299 dA3 cells at 50 UM
Cayman Chemical IsobutyrylLcarnItInchLR 50mg
A diterpene alkaloid inhibits Nav1.7 in HEK293 cells expressing the human channel (IC50 25.8 nM) scavenges DPPH radicals by 65.3 at 1 mM increases the mechanical pain threshold in the von Frey test in streptozotocin-induced diabetic but not non-diabetic mice at 10 mg/kg
Cayman Chemical P4pal10trIfluoROCTAte sal 50mg
An AT1 receptor antagonist (IC50 3.3 nM) inhibits angiotensin II-induced pressor responses in conscious normotensive rats decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 Umol/kg improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water decreases disease severity and NF-KB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg
Cayman Chemical PRfluorobutylsulfonamID 100mg
A TDO inhibitor (IC50 2 UM) selective for TDO over IDO MAO-A and MAO-B as well as a panel of various receptors and transporters at 10 UM reverses tumoral immune resistance in a TDO-overexpressing P815B mastocytoma syngeneic model using mice immunized with the P815 antigen P1A prevents decreases in the number of dopaminergic neurons and increases in microglial cell volume in the substantia nigra and inhibits decreases in intestinal transit in a mouse model of rotenone-induced Parkinsons disease at 50 mg/kg
Cayman Chemical Estron 3sulfATsodIum sal 50mg
An analytical reference standard categorized as an opioid induces respiratory depression in mice intended for research and forensic applications
Cayman Chemical Apocarotenal 50mg
A methyl ester form of L-cysteine increases the output of respiratory tract fluid in anesthetized dogs at 30 and 100 mg/kg has been used in the synthesis of FFAR2/GPR43 agonists
Cayman Chemical 1H 1H 2H 2HPRfluorohexnsu 50mg
A PROTAC that drives BTK degradation induces degradation of BTK in NAMALWA cells from 10-250 nM induces BTK degradation in primary XLA cells expressing wild-type BTK or BTKC481S at 1 UM induces BTK degradation in patient-derived CLL cells
Cayman Chemical AMPR22trIfluoroACTAte sal 50mg
An EIF2AK3 activator increases phosphorylation of eIF2a at serine 51 in HT-29 and MCF-7 cells at 10 UM an effect not seen in cells transfected with EIF2AK3 siRNA reduces phosphorylation of Rb in HT-29 cells (EC50 5.1 UM) rapidly reduces the level of cyclin D1 in HT-29 cells at 10 UM inhibits the growth of HT-29 colon carcinoma cells (GI50 2.1 UM)
Cayman Chemical CnabIdIvarIn 100mg
A secondary bile acid produced by gut microbiota increases the growth of Caco-2 cells at 10 and 20 UM increases Foxp3 CD4 Treg levels in a co-culture of naïve T cells and dendritic cells
Cayman Chemical CnabIgerol 100mg
A pan-Bcl-2 inhibitor inhibits Bcl-xL Bcl-2 Mcl-1 and Bfl-1 (IC50s 0.31 0.32 0.2 and 0.62 UM respectively) inhibits the proliferation of BP3 PC3 and H460 cells (IC50s 0.049 0.13 and 0.56 UM respectively) reduces tumor growth in an M2182 prostate cancer mouse xenograft model at 5 mg/kg