Human Sera
Cayman Chemical ScIadopItysIn 50mg
A biflavonoid with diverse biological activities; reduces Aβ42-induced cytotoxicity in PC12 cells (EC50 = 9.84 μM); decreases methylglyoxal-induced insulin secretion, production of ROS, cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells from 0.1-10 μM; inhibits P-gp (IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells; inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss
Cayman Chemical D-KynurenIn 100mg
An antagonist of HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan; increases levels of intracellular calcium, and decreases forskolin-stimulated production of cAMP, in CHO cells expressing human HCA3/GPR109B when used at 10 and 100, or 1,000 µM, respectively; increases expression of vimentin and decreases expression of E-cadherin in 95D lung cancer cells at 10 µM; has been used as a substrate in fluorometric assays for D-amino acid oxidase activity
Cayman Chemical AcepromazInmaleate 50mg
A phenothiazine antipsychotic and a dopamine receptor antagonist; binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits acetylcholine-induceed contractions of guinea pig ileum (IC50 = 840 nM); inhibits morphine-induced vomiting in dogs; inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively)
Cayman Chemical -LIquIrItIgenIn 100mg
A flavonoid with anticancer activity; cytotoxic to HL-60, HCT8, and B16 cancer cell lines (IC50s = 22.5, 19.5, and 5 μg/ml, respectively)
Cayman Chemical CefmenoxImehydrochlorIde 100mg
A cephalosporin antibiotic; active against clinical isolates of S. aureus, S. epidermidis, S. pyogenes, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. marcescens, and E. cloacae in vitro (MICs = 0.013-6.25 μg/ml); active against various Gram-positive and Gram-negative bacterial infections in mice (ED50s = 0.016-66 mg/kg); increases survival in a mouse model of K. pneumoniae infection (SD50 = 7.6 mg/kg); curative in a mouse model of P. mirabilis urinary tract infection (CD50s = 0.4-0.75 mg/kg)
Cayman Chemical ParecoxIbsodIum salt 100mg
A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)
Cayman Chemical IsoverbascosIde 50mg
A phenylethanoid glycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells at 10 μg/ml; induces apoptosis and production of ROS in, and reduces viability of, OVCAR-3 cells from 7.5-30 μM; inhibits tumor growth in an OVCAR-3 mouse xenograft model at 30 mg/kg; decreases brain amyloid deposition and increases exploratory behavior in Aβ42-infused rats at 2.5 and 5 mg/kg; decreases xylene-induced EAr edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock
Cayman Chemical NItIdInchlorIde 100mg
An alkaloid; active against the F32 chloroquine-sensitive (IC50 = 0.52 µM) and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52, 0.8, and 0.49 µM, respectively) and reduces parasitemia in a mouse model of P. vinckei infection (ED50 = 18.9 mg/kg per day); decreases LPS-induced increases in TNF-α, IL-1β, and IL-6 levels and p65 nuclear translocation in RAW 264.7 cells at 5 µM; decreases serum levels of IL-10, TNF-α, and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia; inhibits proliferation of various cancer cells (IC50s = 2.65-370 ng/ml); induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0.1-10 µM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
Cayman Chemical ZInc PyrIthIon 100mg
A coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities; active against various bacteria (MICs = 1-4 UG/ml) and the fungus P. ovale at 0.01-10 UG/ml; reduces tumor growth in an SCC-4 mouse xenograft model at 1 mg/kg per week for six weeks; topical application completely prevents Aspergillus growth in soy meal-derived adhesives
Cayman Chemical AOCS LNgchaIn Faty ACD Me 50mg
A mixture of long-chain fatty acid methyl esters; contains six saturated and mono- and poly-unsaturated fatty acid methyl esters; intended for use as a reference standard for the detection of fatty acids in corn, cottonseed, soybean, safflower, sesame, poppy seed, walnut, kapok, and rice oils, among others, by GC-MS
Cayman Chemical Sproxamn 50mg
A tertiary amine fungicide; an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase; inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L); reduces network formation in rat cortical cultures from 0.03-30 μM; cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM)
Cayman Chemical ThIoacetazon 100mg
An antitubercular agent; active against M. tuberculosis H37Rv, M. kansasii Bostrom, and M. avium serotype 2 (MICs = 0.3, 0.6, and 20 UG/ml, respectively)
Cayman Chemical 1Pentadecnoylracglycerol 100mg
A monoacylglycerol; has been found in wheat bran extracts; levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate