Human Sera
Cayman Chemical DIbutyrylCyclIc GMPsodIum 50mg
A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase
Cayman Chemical SncyclInhydrochlorIde 100mg
A semisynthetic tetracycline antibiotic; more active than tetracycline against 339 strains of anaerobic bacteria (MIC90s = 1 and 32 μg/ml, respectively); active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains (MICs = 0.06-1 μg/ml); active against S. aureus in mice (ED50s = 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively)
Cayman Chemical CarteololhydrochlorIde 100mg
A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 UG/kg, respectively); the (R) and (S)-enantiomers EAch reduce intraocular pressure in rabbits (1% solution)
Cayman Chemical GuvacInhydrochlorIde 50mg
An inhibitor of GABA uptake (IC50 = 10 μM; Ki = 14 μM) in rat hippocampal brain slices; decreases spontaneous activity in mice; decreases tail flick reaction time in a rat model of morphine analgesia
Cayman Chemical PromestrIen 50mg
A synthetic estrogen; reduces vaginal atrophy and decreases in endometrial and myometrial wall thickness in ovariectomized rats when applied as a topical gel
Cayman Chemical NorcholIc AcId 100mg
A bile acid and derivative of cholic acid; urine levels are increased in patients with liver cirrhosis or CTX
Cayman Chemical AEBSFhydrochlorIde 50mg
A water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins; also inhibits NADPH oxidase
Cayman Chemical Maltotetraose 50mg
A tetrasaccharide; increases the α-amylase synthesis rate in B. stearothermophilus three-fold greater than sucrose or glucose when used at at 0.1 mM; inhibits the growth of E. carotovora in a cylinder-agar plate assay at 750 μg/ml; inhibits TNF-α-induced expression of ICAM-1 in MOVAS-1 mouse VSMCs
Cayman Chemical DInotefurn 100mg
A neonicotinoid insecticide; a nAChR agonist (EC50 = 7.6 µM for the induction of inward currents in isolated P. americana neurons); induces mortality in adult P. americana; lethal to insecticide-sensitive or -resistant strains of A. gambiae, C. quinquefasciatus, and A. aegypti in larval (LC50s = 0.14-0.44 mg/L) and adult (LD50s = 0.18-31.16 ng/mg) bioassays; has been found in a variety of commercial foodstuffs, including rice, cucumber, milk, egg, and pork samples, as well as in water samples from freshwater streams
Cayman Chemical Setpprnt 50mg
An orally bioavailable antagonist of CRTH2/DP2 (IC50 = 6 nM for the human receptor); selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and EP2 and EP4 in a β-arrestin assay (IC50s = 2,600 and >10,000 nM, respectively); inhibits PGD2-induced calcium flux in HEK293 cells expressing human CRTH2/DP2 (IC50 = 30 nM); inhibits PGD2-induced shape change in human eosinophils (IC50 = 235 nM)
Cayman Chemical BuclIzInhydrochlorIde 50mg
An antihistamine; reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs at 1 mg/kg; induces gross malformations and bone malformations in rats from 40-200 mg/kg; inhibits cancer cell growth by binding to TCTP and inducing cell differentiation
Cayman Chemical Medroxyprogesteron 100mg
A progesterone receptor agonist (Ki = 241 nM); a metabolite of medroxyprogesterone 17-acetate; induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM); increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM)
Cayman Chemical PAPA Nonate 50mg
PAPA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 15 minutes and 77 minutes at 37°C and 22-25°C, respectively, pH 7.4, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Cayman Chemical 3 4-DmAhydrochlorIde 50mg
An MDMA analog that appears to act as a serotonin-norepinephrine-dopamine releasing agent binding to and inhibiting uptake at noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM and IC50s = 253.4 and 108 μM, respectively); significantly less potent than MDMA; intended for forensic and research applications