Human Sera
Cayman Chemical TermItomycamIde B 50mg
A fatty acid amide from T. titanicus that at 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin
Cayman Chemical FlunIxInmeglumIn 50mg
A COX inhibitor (IC50s = 3.24 and 0.55 µM for COX-1 and COX-2, respectively); inhibits carrageenan-induced PGE2 and TXB2 production in sheep exudate and serum, respectively, at 1.1 mg/kg; has anti-inflammatory, analgesic, and antipyretic activity in horses at 1.1 mg/I/kg
Cayman Chemical PhenIndIon 100mg
An anticoagulant and vitamin K antagonist; inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in liver homogenates in a concentration-dependent manner; inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively, at 0.5 mg/100 g; dietary administration inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively, at 4 mg/kg per day
Cayman Chemical MagnoflorIn 50mg
An alkaloid with diverse biological activities; reduces LPC-induced hemolysis in a rat erythrocyte suspension from 0.01-10 μM; induces intracellular chloride influx in neuroblastoma cells at 10 μM; reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells; improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment at 20 mg/kg
Cayman Chemical SuramInsodIum salt 100mg
A polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities; is negatively charged at physiological pH therefore exhibiting polypharmacology; reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 UG/ml); induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis; reduces tumor volume in PDX mouse models of malignant mesothelioma at 60 mg/kg
Cayman Chemical PalmItoylDLcarnItInchLR 50mg
A long-chain acylcarnitine with both intracellular and extracellular roles; transported into mitochondria to deliver palmitate for fatty acid oxidation; alters calcium mobilization in many cell types; also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability
Cayman Chemical 1S 3S3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical 2MethylmethcathInonhydroc 50mg
An analytical reference standard categorized as a cathinone; a potential impurity in the synthesis of 4-methylmethcathinone; intended for research and forensic applications
Cayman Chemical GrnIsetronhydrochlorIde 100mg
A 5-HT3 receptor antagonist (Ki = 3.9 nM) with antiemetic activity; selective for 5-HT3 over 5-HT4 receptors (Ki = >1,000 nM); increases the latency to first vomiting episodes and reduces the number of vomiting episodes in a canine model of cisplatin-induced emesis at 0.3, 1, and 3 mg/kg, p.o.; increases the latency to first vomiting episode and reduces the number of vomiting and retching episodes in a ferret model of emesis induced by doxorubicin and cyclophosphamide at 0.1, 0.3, and 1 mg/kg
Cayman Chemical ThIomyrIstoyl 50mg
A potent and selective SIRT2 inhibitor (IC50s = 0.028, 98, >200, and >200 μM for SIRT2, SIRT1, SIRT3, and SIRT5-7, respectively); inhibits acetyl-H3K9 peptide and NAD binding to SIRT2 and promotes c-Myc degradation in a dose-dependent manner; exhibits selective cytotoxicity (IC50s = 8.4-36.8 and >50 μM for cancerous and non-cancerous cell lines, respectively); decreases tumor volume and increases areas of necrosis in an MDA-MB-231 mouse breast cancer xenograft model; increases tumor-free survival time in a MMTV-PyMT mouse mammary tumor model
Cayman Chemical NADIFLOXACIN 100MG
A fluoroquinolone antibiotic; active against clinical isolates of S. aureus, coagulase-negative staphylococci, P. acnes, and P. granulosum (MIC50s = 0.03, 0.06, 0.25, and 0.125 mg/L, respectively); inhibits the activities of DNA gyrase and topoisomerase IV (IC50s = 8.83 and 3.22 mg/L, respectively, for the S. aureus enzymes); inhibits P. acnes-induced increases in the production of IFN-γ, IL-1β, and IL-12p70 in human PBMCs, as well as reduces P. acnes-induced increases in the production of IL-8 and IL-6 in isolated human keratinocytes; reduces the number of skin lesion CFUs in a mouse model of burn wounds infected with S. aureus or P. acnes when applied topically as a cream at 1%
American Research Products Inc Human lysophosphatidic acid L
Human lysophosphatidic acid (LPA) Elisa kit from CUSABIO Detection Range 3 9 ng/mL-250 ng/mL Sensitivity 3 9 ng/mL Sample serum plasma tissue homogenates Method Competitive
Cayman Chemical FenoterolhydrobromIde 50mg
An analytical reference standard categorized as a β2-adrenergic receptor agonist; has been used as a performance-enhancing drug in sports doping and is banned by WADA; intended for research and forensic applications
Cayman Chemical Brmondn 50mg
An α2-adrenergic receptor agonist (Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells); selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain); topical application lowers intraocular pressure in DBA/2J mice, a glaucoma model, to control levels at 0.1% solution; inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia at 1 mg/kg per day
Cayman Chemical TelmIsartn 100mg
A nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM); a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM); potently reduces blood pressure