Human Sera
Cayman Chemical PD 153035hydrochlorIde 50mg
A highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC50 = 29 pM); rapidly suppresses autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells
Cayman Chemical 6-MethylmercaptopurIn 50mg
A metabolite of 6-MP; formed from 6-MP via methylation by thiopurine S-methyltransferase; levels are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP
Abcam Human Anti-Brucella IgM ELISA Kit, 1 x 96 Tests
Human Anti-Brucella IgM ELISA Kit is a Indirect ELISA kit for the measurement of Human Anti-Brucella IgM in Human in Citrate plasma, Heparin Plasma, Serum samples.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical XalIprodenhydrochlorIde 50mg
A 5-HT1A agonist (IC50 = 4.3 nM in a radioligand binding assay); selective for 5-HT1A over 5-HT2 and α1-adrenergic receptors (IC50s = 697 and 630 nM, respectively), as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s = ≥10 µM for all) but also binds σ receptors (IC50 = 73 nM); increases NGF-induced neurite outgrowth and α-actinin levels in PC12 cells at 250 nM; decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by 4-VO and sciatic nerve crush injury, respectively, at 10 mg/kg per day; inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of EAE induced by myelin basic protein at 10 mg/kg per day
Revvity Health Sciences Inc CytoStar-T 96-well plate, 100 plates
CytoStar-T 96-well plate, 100 plates
Cayman Chemical PalmItoylDLcarnItInchlor 100mg
A long-chain acylcarnitine with both intracellular and extracellular roles; transported into mitochondria to deliver palmitate for fatty acid oxidation; alters calcium mobilization in many cell types; also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability
Cayman Chemical DrondaronhydrochlorIde 50mg
An antiarrhythmic agent; inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively); reduces sinus frequency and prolongs APD in isolated rabbit ventricular myocardium at 50 and 100 mg/kg; increases atrial APD and the AERP in a dog model of atrial fibrillation
Cayman Chemical NormetnphrInhydrochlorId 50mg
An active metabolite of norepinephrine; induces contractions in isolated rabbit aortic strips; inhibits norepinephrine uptake in isolated rat heart (IC50 = 200 µM); plasma levels of normetanephrine are increased in patients with von Hippel-Lindau disease and pheochromocytomas compared with patients with von Hippel-Lindau disease without pheochromocytomas; has been used as a marker of authentic human urine specimens
Cayman Chemical DebrIsoquInhemIsulfate 100mg
A post-ganglionic sympathetic blocker; increases accumulation of l-m-octopamine in isolated rabbit heart at 1 mM; reduces norepinephrine levels in the left and right atrium and ventricles, as well as the mesenteric and femoral arteries in anesthetized dogs at 5 mg/kg per day for 7 days; decreases mean aortic pressure, heart rate, and total peripheral vascular resistance in the same model.
Cayman Chemical 5-O-MethylvIsamIosIde 100mg
A chromone with diverse biological activities; inhibits the protein-protein interaction between histone H3 and 14-3-3ε and phosphorylation of histone H3, as well as induces cell cycle arrest at the G2/M phase, in HT-29 cells at 10 µM; inhibits compound 48/80-induced histamine release in LAD 2 mast cells from 10-100 µM; inhibits perivascular adventitia leukocyte infiltration and improves neurological deficits in a rat model of subarachnoid hemorrhage-induced vasospasm at 400 UG/kg; has been used as a quality control marker of S. diviaricata roots
Abcam SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent, 100MG
MW 231.23 Da, Purity >94%. Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Valeroyl SalIcylate 100mg
Valeroyl salicylate is a selective, irreversible inhibitor of COX-1. The IC50 values for ovine COX-1 and -2 are 0.8 mM and 15 mM, respectively.{1364} The half-lives for inactivation of human recombinant and ovine COX-1 in the presence of 500 µM valeroyl salicylate are 12 and 45 minutes, respectively.{1284,1364}
Cayman Chemical FlunIxInmeglumIn 100mg
A COX inhibitor (IC50s = 3.24 and 0.55 µM for COX-1 and COX-2, respectively); inhibits carrageenan-induced PGE2 and TXB2 production in sheep exudate and serum, respectively, at 1.1 mg/kg; has anti-inflammatory, analgesic, and antipyretic activity in horses at 1.1 mg/I/kg
Cayman Chemical BrIvnIb AlnInate 50mg
A prodrug form of brivanib; reduces hepatic angiogenesis and VEGF, TGF-β1, CD31, and phosphorylated VEGFR2 and FGFR levels in a bile duct-ligated rat model of cirrhosis at 3 mg/kg per day; reduces tumor growth in an L2987 non-small cell lung cancer mouse xenograft model, exhibiting 97% tumor growth inhibition at 107 mg/kg
Cayman Chemical 1Pentadecnoylracglycerol 50mg
A monoacylglycerol; has been found in wheat bran extracts; levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate