Human Sera
Cayman Chemical E8Methyl6nonoIc AcId 100mg
A potential thermal degradant of capsaicin with possible mutagenic effects
Cayman Chemical 7-MethylgunIn 100mg
A metabolite of the natural purine base that is generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods; carcinogenic biomarker for cigarette smoking that is detectable in urine
Cayman Chemical 2 3MehylendIoxy PyrovalRo 50mg
A potential psychoactive designer drug structurally related to 3,4-MDPV; intended for forensic purposes
Cayman Chemical ElaIdIc AcId 100mg
A trans fatty acid; reduces arachidonic acid-induced HHT and HETE formation and increases arachidonic acid-induced synthesis of PGE2, PGF2α, PGD2, and TXB2 in isolated human platelets; induces apoptosis in HUVECs from 0.1-5 mmol/L; reduces palmitic acid-induced cardiac and hepatic autophagy in mice at 100 mg/kg
Cayman Chemical DLthreoPPMPhydrochLRIde 50mg
An inhibitor of glucosylceramide synthase; inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, at 20 µM; inhibits sphingomyelin synthase activity in P. falciparum-infected erythrocytes and inhibits growth of P. falciparum (IC50 = 0.85 µM)
Cayman Chemical RefametInIb 50mg
An allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively); blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM); orally available and active in human tumor xenograft models
Cayman Chemical T16A Inh-A01 50mg
An aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM; blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels
Cayman Chemical ArachIdoyl glycIn 50mg
Consists of arachidic acid with glycine attached at its carboxy terminus
Cayman Chemical ClemIzolehydrochlorIde 50mg
An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations; less potently blocks TRPC5 (IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels
Cayman Chemical 3 4trImethylenaPyrrolId 50mg
A cathinone whose physiological and toxicological properties are not known
Cayman Chemical 4mthylN NDImthylcathInon 50mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical LamotrIgIn 100mg
An anticonvulsant; inhibits Nav1.2, Nav1.5, and Nav1.8 in HEK293 cells expressing the recombinant human channels (IC50s = 10, 62, and 96 μM, respectively); inhibits high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by ω-conotoxin GVIA and ω-agatoxin IVA; protects against MES-induced seizures in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively); decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg)
Cayman Chemical trns-VaccenIc AcId 100mg
An ω-7 fatty acid; dietary administration reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome at 1% w/w; decreases hepatocellular ballooning and steatosis in the same model; dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice
Cayman Chemical Hexnoyl GlycIn 50mg
An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation