Human Sera
Cayman Chemical 8 4bromophenyl1 3 5 7tet 100mg
An intermediate in the synthesis of BODIPY-containing dyes; has been used as a precursor in the synthesis of BODIPY-containing photosensitizer dyes with antibacterial activity
Cayman Chemical 5-HydroxymethylcytIdIn 50mg
A derivative of cytidine; has been found as an RNA modification in Archaea, bacteria, and eukaryotes
Cayman Chemical SureLIghtBPhycoerythrInB 100mg
Because of its high quantum yield, B-PE is considered the world’s brightest fluorophore. It is compatible with commonly available lasers and gives exceptional results in flow cytometry, Luminex and immunofluorescent staining. B-PE is also less “sticky” than common synthetic fluorophores and therefore gives less background interference. Uses: Flow cytometry, Fluorescence-activated cell sorting, Custom Antibody labeling, Luminex, and T Cell labeling
Cayman Chemical 1Pentadecnoylracglycerol 50mg
A monoacylglycerol; has been found in wheat bran extracts; levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate
Cayman Chemical ArylpIperazIn 5k 50mg
A FATP1 inhibitor (IC50 = 4.6 nM for the human protein); reduces neutral and polar lipid accumulation induced by linoleic acid in MDA-MB-231 cells at 12.5 µM; decreases ATP and BODIPY-palmitate levels in CD37-/- knockout BJAB cells but not in wild-type BJAB cells at 12.5 µM; induces cell death in MDA-MB-231, MCF-7, HCC1806, and BT474 cells at 12.5 µM
Cayman Chemical SolIfenacInsuccInate 100mg
A muscarinic M1, M2, and M3 receptor antagonist (Kis = 25, 125, and 10 nM, respectively, for the human receptors); inhibits carbachol-induced calcium mobilization in isolated guinea pig detrusor muscle cells (Ki = 4 nM); inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle; inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats from 0.03-1 mg/kg
Cayman Chemical TroglItazon 50mg
A selective agonist of PPARγ (EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay); selective for PPARγ over PPARα and PPARδ, at which it is inactive at ≤10 μM; exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively, at 500 mg/kg twice per day; induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells at 10 μM and increases apoptosis in these cells at ≥30 μM
Cayman Chemical OrselInIc AcId 100mg
A fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities; scavenges DPPH radicals (IC50 = 5 mM); prevents PAF-induced PARP cleavage in PC12-AC cells and PAF-induced cytotoxicity in Pafr-/-mouse cerebellar granule cells at 1 μg/ml
AdipoGen BioStab Antibody Stabilizer
Free or conjugated antibodies are often used in immunoassays, either in the system specific detector antibody plus streptavidin-HRP or in the system analyte-specific antibody plus species-specific antibody-HRP-conjugate. Both systems allow a high flexibility at lower costs. BioStab Antibody Stabilizer dramatically extends the life of your valuable antibodies, allowing much more consistent results over extended periods of time compared to daily prepared dilutions. BioStab Antibody Stabilizer can be used in ELISA, Western Blotting, Immunohistochemistry and any other applications which require marker or biotinylated antibodies. It is supplied as a ready-to-use solution for dilution of antibodies. This stabilizer contains a minimum amount of a surfactant. The stabilizer is free of any protein to minimize potential unspecific interactions. The method below is strongly recommended for standard assay procedures and reduces loss of valuable conjugates and assay-to-assay variations.
Cayman Chemical NVP-BEZ235hydrochlorIde 50mg
A potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies; inhibits PI3K isoforms and mutants with low nanomolar IC50 values; directly blocks cell growth and indirectly inhibits angiogenesis
Cayman Chemical GadoterIdol 50mg
An MRI contrast agent; improves visualization of intraparenchymal and meningeal tumors compared to surrounding normal rat brain tissue in an orthotopic model of brain cancer at 0.25 mmol/kg; has been used to label MSCs in vitro to track their migration to spinal cord injury lesions in vivo
Cayman Chemical EnIatIn Complex 50mg
A mixture of cyclohexadepsipeptides commonly isolated from fungi that act as ionophores, forming pores in cellular membranes to allow selective ion transport; exhibits antimicrobial activity against a variety of eukaryotic and prokaryotic genera, inhibits acyl-CoA:cholesterol acyltranferase, and induces apoptosis in several cancer lines
Cayman Chemical N-ArachIdonyl DopamIn 50mg
An arachidonoyl amino acid and CB1 receptor agonist (Ki = 250 nM in rat brain membranes, which highly express CB1 receptors); selective for CB1 over CB2 receptors (Ki = 12,000 nM in rat spleen membranes, which highly express CB2 receptors); induces intracellular calcium mobilization in N18TG2 neuroblastoma cells (EC50 = 0.7 µM); inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 0.25 µM); induces hypothermia, catalepsy, hypolocomotion, and analgesia in mice at 10 mg/kg
Cayman Chemical SB-399885hydrochlorIde 50mg
A 5-HT6 receptor antagonist (Ki = 0.72 nM); >200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM; inhibits 5-HT-induced cAMP accumulation in HeLa cells expressing recombinant human 5-HT6 receptors (pA2 = 7.85); increases the seizure threshold in a rat model of MES-induced seizures; reduces escape latency in the Morris water maze in aged rats and reverses scopolamine-induced impairments in the novel object recognition task in adult rats at 10 mg/kg; has antidepressant and anxiolytic-like effects in mice and rats, respectively
Cayman Chemical NItrendIpIn 50mg
A dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels; also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively