Human Sera
Cayman Chemical SItaglIptInphosphate 100mg
A potential antitumor agent binds preferentially to mitochondrial membranes and disrupts their function induces apoptosis in HER-1/EGFR-expressing breast carcinoma cell lines can be used to visualize mitochondria under confocal microscopy
Cayman Chemical LeupeptInhemIsulfate 50mg
A major metabolite of sildenafil formed via oxidative metabolism of sildenafil by CYP3A4 CYP3A5 and CYP3A7
Cayman Chemical 3-MethyladenIn 50mg
Peptde Sequence human GPR40 amno acds 210-222 To be used n conjuncton wth Cayman s GPR40 polyclonal antbody (Catalog No 10007605) to block proten-antbody complex formaton durng mmunochemcal analyss of GPR40
Cayman Chemical RosIglItazonmaleate 100mg
A potent non-selective inhibitor of PKA with an IC50 value of 0 14 UM (Ki 48 nM) that is widely used to disrupt PKA signaling inhibits S6K1 MSK1 ROCK2 PKBa and MAPKAP-K1b with IC50 values of 0 08 0 12 0 27 2 6 and 2 8 UM respectively
Cayman Chemical CatharnthIntartrate 100mg
A protein cross-linking agent isolated from G jasminoides Ellis inhibits UCP2 activity 5 UM genipin increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose induces apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells
Cayman Chemical ndrographolIde 100mg
A naturally-occurrng but uncommon form of sphngosne accountng for approxmately 13 of the sphngosne n human skn can be phosphorylated by sphngosne knases to produce C17 sphngosne-1-phosphate
Cayman Chemical DorsomorphIn 50mg
A dterpene amne wth dverse bologcal actvtes nhbts PDHK (C50 9 5 UM) actve aganst B cnerea (EC50 70 UM) nduces apoptoss n UACC-903 and 1205Lu cell lnes at a concentraton of 3 UM reduces blood glucose levels n an ob/ob mouse model of type dabetes at 100 and 300 Umol/kg per day
Cayman Chemical BenazeprIlhydrochlorIde 100mg
A cell-permeable irreversible inhibitor of EGFR kinase activity (IC50 0 70 nM) used in cells and in vivo to irreversibly inhibit EGFR signaling
Cayman Chemical TasImelteon 50mg
A selective EZH2 inhibitor (IC50s 0 5 and 2 5 nM for wild-type EZH2 and Y641N mutant EZH2 respectively) decreases cellular levels of H3K27me3 and H3K27me2 (EC50s 56 and 65 nM respectively) triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of NHL cell lines
Cayman Chemical OxyphenonIumbromIde 100mg
A reversible inhibitor of COMT (Ki 0 27 nM for human recombinant COMT) crosses the blood brain barrier and inhibits both peripheral and central COMT activity
Cayman Chemical RopIvacaInhydrochlorId 50mg
An inhibitor of GSK3 (34 inhibition when used at a concentration of 2 5 UM) inhibits androgen receptor transactivation and translocation to the nucleus in PCa prostate cancer cells increases nuclear export of the androgen receptor in PC3 prostate cancer cells dose-dependently potentiates peak current densities
Cayman Chemical EstramustIn PhosphATsodIu 50mg
A mitochondrial-targeted neuroprotective agent binds to and inhibits mPTP opening prevents arachidonic acid-induced mPTP opening in HeLa cells at 10 UM promotes survival of motor neurons in vitro in the absence of neurotrophic factors (EC50 3 2 UM) promotes survival of motor neurons in vivo in a neonatal rat model of facial nerve axotomy at 100 mg/kg per day delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of ALS increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain at 30 and 100 mg/kg
Cayman Chemical MIlnacIprnhydrochlorIde 100mg
A monosaccharide component of glycosaminoglycans including heparin conformationally flexible allowing it to bind metal ions and may be important for the antithrombotic activity of heparin
Cayman Chemical PyrIdostIgmInbromIde 100mg
A cell-permeable inhibitor of PCSK9 secretion (IC50 4 8 UM) promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels