Human Sera
Cayman Chemical TImololmaleate 100mg
A non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively; used to reduce intraocular pressure in research models of ocular hypertension and glaucoma
Cayman Chemical VInblastInsulfate 50mg
An antimicrotubule drug used to treat Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer; inhibits steady-state tubulin addition to microtubules (Ki = 0.18 μM) and inhibits B16 melanoma cell proliferation (IC50 = 1 nM)
Cayman Chemical SB-206553hydrochlorIde 50mg
A 5-HT2C (Ki = 12.6 nM) and 5-HT2B receptor antagonist; selective for 5-HT2C and 5-HT2B over a panel of eight 5-HT receptor subtypes and six additional receptors (Kis = >1 µM for all); inhibits 5-HT-induced contraction of isolated rat stomach fundus (EC50 = 4.8 nM); inhibits 5-HT-induced inositol phosphate release in HEK293 cells expressing human 5-HT2C receptors (EC50 = 3.16 nM); increases the time spent in active social interaction in a social interaction test and increases punished responding in the Geller-Seifter conflict test in rats at 2 and 20 mg/kg; increases suppressed responding in a marmoset conflict model of anxiety at 15 and 20 mg/kg
Cayman Chemical SRT 3025hydrochlorIde 50mg
A SIRT1 activator; increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse BMDMs at 2 µM; inhibits proliferation of SU.86.86 cells (IC50 = 0.98 µM); decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet at 3.18 g/kg
Cayman Chemical PalmItoleoyl EthnolamIde 100mg
An N-acylethanolamine that is produced endogenously from palmitoleic acid
Cayman Chemical PIperlongumIn 100mg
An alkaloid with anticancer and antioxidant activities; binds to GSH and inhibits the GSH-GSTP1 protein-protein interaction; reduces the viability of A549 and NCI H460 cells (IC50s = 14.91 and 13.72 µM, respectively); reduces tumor growth in an A549 mouse xenograft model at 2.5 and 5 mg/kg twice per week; reduces plasma glucose levels, as well as levels of plasma and pancreatic TBARS and lipid hydroperoxides in a rat model of streptozotocin-induced diabetes
Cayman Chemical Olmesartn MedoxomIl 100mg
A prodrug form of olmesartan; inhibits the angiotensin II pressor response in normotensive rats at 0.1 mg/kg; reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, at 10 mg/kg per day, as well as in chow-fed control animals at 11.4 mg/kg per day; inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats
Cayman Chemical 1S 3R3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical 1S 3R3AmInocyclopentn c 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical PCMPAhydrochlorIde 50mg
A synthetic drug which is structurally related to the psychoactive compound phencyclidine; recently been identified as a likely drug of abuse
Cayman Chemical ParthenolIde 50mg
A natural sesquiterpene lactone which inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml); induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription; directly binds the pattern recognition receptor NOD2
Cayman Chemical 7-NItroIndazole 50mg
A non-selective inhibitor of NOS isoforms in vitro (IC50s = 0.71, 0.78, and 5.8 µM for rat nNOS, bovine eNOS, and rat iNOS, respectively); shows good anti-nociceptive effects without affecting blood pressure via inhibition of eNOS in vivo
Cayman Chemical DPTA Nonate 50mg
A NO donor with a half-life of three hours at 37°C, pH 7.4; liberates two moles of NO per mole of parent compound
Cayman Chemical LOMEGUATRIB 50MG
A modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM)
Cayman Chemical ArcaInsulfate 100mg
An NMDA receptor antagonist (IC50 = 9.13 µM); inhibits NMDA and glycine-induced inward currents in X. laevis oocytes expressing rat NMDA receptors (IC50 = 60.1 µM); impairs contextual and auditory fear conditioning in rats when administered post-training at 10 mg/kg, i.p.