Human Sera
Cayman Chemical SKQ1bromIde 50mg
A mitochondrial antioxidant; decreases transmembrane potential and production of ROS; prevents neuronal loss and synaptic damage in rat AD model; slows development of ocular pathologies; prevents acute phenoptosis following rhabdomyolysis, stroke, and myocardial infarction
Cayman Chemical ErgoloIdmesylates 50mg
A mixture of alkaloids with diverse biological activities; blocks norepinephrine-induced reflex vasodilation and vasoconstriction in dogs when injected into the kidney at a dose of 0.15 mg; blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner; acts as an erectogenic agent in rats
Cayman Chemical TebufenozIde 50mg
An insecticide and ecdysone receptor agonist (IC50 = 0.85 nM); induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva); inhibits p-glycoprotein in LLC-PK1 porcine kidney epithelial cells transfected with MDR1 (IC50 = 21.5 µM); decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 UG/ml
Cayman Chemical TuftsInhumntrIfluoroace 50mg
A phagocytosis-stimulating peptide; binds human PMN, human monocytes, and mouse macrophages (Kds = 130, 125, and 53 nM, respectively); increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages at 200 nM; increases phagocytosis of S. aureus, L. monocytogenes, and S. oviformis by isolated human, mouse, rabbit, dog, or guinea pig phagocytes from 0.01-0.15 UG/ml; increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma at 0.1, 0.5, and 25 mg/kg
Cayman Chemical MaduramIcInamonIum salt 100mg
A polyether ionophore antibiotic; selectively binds to monovalent cations over divalent cations; active against Gram-positive bacteria (MICs = 0.9-125 UG/ml); reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively); reduces P. berghei transmission in a mouse model of malaria at 4 and 8 mg/kg; reduces the severity of lesions and completely protects chicks against mortality in a model of E. tenella-induced coccidiosis at 5-10 ppm in the diet
Cayman Chemical CarbIdopahydrate 100mg
A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo
Cayman Chemical RImntadInhydrochlorIde 100mg
A derivative of amantadine with antiviral activity; inhibits recombinant influenza A M2 protein expressed in X. laevis oocytes (IC50 = 10.8 µM); inhibits recombinant HCV p7 protein expressed in HEK293 cells (IC50s = 0.7, 24, 1.6, and 3.0 nM for HCV genotypes 1a, 2a, 3a, and 4a, respectively); inhibits cytotoxicity induced by the influenza A strains A/PR/8/34 (H1N1) and A/HK/7/87 (H3N2), but not the influenza B strain B/HK/72, in MDCK cells (EC50s = 18, 0.62, and >500 µM, respectively); increases the survival rate of mice infected with the influenza A strain infected with the influenza A strain A2/Jap/305 from 20 to 90% at 24 mg/kg when administered two hours post-infection; has trypanocidal activity against bloodstream forms of T. brucei in vitro (IC50 = 1.26 UG/ml)
Cayman Chemical EIcosapentaenoyl ChlorIde 50mg
A derivative of eicosapentaenoic acid; has been used in the synthesis of fatty acid conjugates to enhance lipophilicity and cell permeability of bioactive compounds
Cayman Chemical LoxIglumIde 50mg
A CCK receptor antagonist (Kis = 9.1 and 0.33 μM for CCK-8 binding to central and peripheral CCK receptors, respectively); inhibits CCK-8-induced release of acetylcholine from isolated guinea pig gallbladders (IC50 = 10 nM); reduces the invasion of PANC-1 and MiaPaCa-2 human pancreatic cancer cells at 50 μM; reduces DNA synthesis in PC-TI and PC-YY human pancreatic cancer cells (IC50s = 160 and 74 μM, respectively); reduces tumor growth rate in PC-TI and PC-YY mouse xenograft models at 250 mg/kg; toxic to mice (LD50s = 440-500 mg/kg); reduces serum concentrations of CCK, amylase, and lipase as well as tissue hemorrhaging and acinar cell necrosis in a rat model of acute pancreatitis at 50 mg/kg
Cayman Chemical SItaglIptInphosphate 100mg
A DPP-4 inhibitor (IC50 = 18 nM); selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases; improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well as ob/ob and high-fat diet fed mice; reduces hyperglycemia in mice fed a high-fat diet with streptozotocin-induced diabetes
Cayman Chemical 4AmIno5 bromomethyl2met 50mg
A heterocyclic building block; has been used in the synthesis of vitamin B1 analogs and thiaminephosphoric acid esters
Cayman Chemical MagnoflorIn 50mg
An alkaloid with diverse biological activities; reduces LPC-induced hemolysis in a rat erythrocyte suspension from 0.01-10 μM; induces intracellular chloride influx in neuroblastoma cells at 10 μM; reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells; improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment at 20 mg/kg
Cayman Chemical -GalocatechIn 50mg
A polyphenol and flavonoid that has diverse biological activities; inhibits adherence of P. gingivalis onto human buccal epithelial cells by >50% at 250 μg/ml; has antimutagenic properties in UV-irradiated E. coli cells; inhibits cell death induced by D-galactosamine and TNF-α in primary cultured mouse hepatocytes by 29.9% at 80 μM; inhibits HCT116 colorectal cancer cell proliferation by 57% at 100 μM
Cayman Chemical AloglIptInbenzoate salt 100mg
An orally bioavailable DPP-4 inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, FAP, and tryptase (IC50s = >100,000 nM); inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma); increases plasma GLP-1 and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats (10 mg/kg); decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days (2.8 mg/kg per day)
Cayman Chemical 1R 9SHydrastIn 50mg
An inhibitor of dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells); inhibits tyrosine hydroxylase activity; inhibits dopamine release in the presence of a high extracellular K+ level (IC50 = 66.5 µM); inhibits L-type and caffeine-activated store-operated Ca2+ channels; prevents Ca2+ leakage from intracellular stores