Human Sera
Cayman Chemical BromocrIptInmesylate 100mg
A dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1-5 receptors, respectively); also binds to 5-HT1A and 5-HT1D (Kis = 12.9 and 10.7 nM, respectively), as well as α1-adrenergic receptors (Kis = 1.12-4.17 nM); restores locomotor activity, without inducing dyskinesia, in a MPTP-induced macaque model of Parkinson’s disease at 5 mg/kg
Cayman Chemical LeuEnkephalIntrIfluoROCt 50mg
A neuropeptide and δ- and µ-opioid receptor agonist (Kis = 4.0 and 3.4 nM, respectively); selective for δ- and µ- over κ-opioid receptors (Ki = >1,000 nM); decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension at 1 mg/kg; increases the tail-flick threshold and latency to tail flick in the tail-pressure test and tail-flick test, respectively
Cayman Chemical EsmololhydrochlorIde 50mg
A β1-AR antagonist; binds to β1-ARs (Kd = 100 nM in isolated cardiac myocytes); 34-fold selective for β1- over β2-ARs; inhibits ICa.L and the INa in rat cardiac myocytes (IC50s = 50 and 169 μM, respectively)
Sigma Aldrich Fine Chemicals Biosciences Human Serum from male AB c
serum Human Serum from male AB c
Sigma Aldrich Fine Chemicals Biosciences IgG from human serum reage50MG
IgG from human serum reage50MG
Cayman Chemical HenIcosnoIc AcId 100mg
A very long-chain saturated fatty acid; found in plants and animals, including human milk fat; also found in LPS from Gram-negative bacteria
Cayman Chemical PrenylamIn 100mg
A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg
Cayman Chemical 3 4mthylendIoypropIopheno 50mg
An analytical reference standard categorized as a precursor in the synthesis of cathinones; intended for research and forensic applications
Cayman Chemical DInIconazole 100mg
A triazole fungicide; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; fungicidal against B. cinerea, S. fimicola, F. graminearum, S. cepivorum, and B. sorokiniana (EC50s = 0.012, <0.001, 0.008, 0.02, and 0.06 mg/l, respectively); decreases height and leaf area in bean plants when applied to roots at 5 mg/l; exhibits dose-dependent toxicity in zebrafish
Cayman Chemical DodecylphosphocholIn-d38 100mg
An internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS
Cayman Chemical RaltItrexed 100mg
An inhibitor of thymidylate synthase (Ki = 62 nM); inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM); reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model at 4 mg/kg; reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model
Cayman Chemical TIrapazamIn 100mg
A hypoxia-activated anticancer agent; is converted to an oxidizing radical under hypoxic conditions; can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity; induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively); induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions; sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model; sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model at (0.08 mmol/kg)