Human Sera
Cayman Chemical LM11A-31hydrochlorIde 50mg
An internal standard for the quantification of JWH 016 by GC- or LC-MS intended for research and forensic applications
Cayman Chemical SafInamIdemesylate 50mg
A precursor in the biosynthesis of the plant hormone N6-(2-isopentenyl)adenine which regulates diverse events in plant growth and development can also alter post-transcriptional processes in mammalian cells
Cayman Chemical VIlazodonhydrochlorIde 50mg
An aromatase inhibitor (IC50 7 5 UM) inhibits estrogen synthesis suppressing estrogen levels in post-menopausal women
Cayman Chemical 9-DeazagunIn 50mg
A competitive inhibitor of PFKFB3 (IC50 23 UM) that causes a rapid reduction in F26BP glucose uptake and lactate secretion resulting in cell cycle arrest in Jurkat cells markedly reduces intracellular F26BP glucose uptake and growth of established tumors in mice also blocks angiogenesis
Cayman Chemical IrsogladInmaleate 50mg
A fluorogenic substrate forBgalactosidase cleaved byBgalactosidase to release the fluorescent moiety resorufin ex/em 570/580 nm respectively
Cayman Chemical SulfaclozInsodIum salt 100mg
A compound with anesthetic activity increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices at 100 M induces loss of righting reflex in tadpoles (EC50 0 53 M)
Cayman Chemical trns-ZeatIn RIbosIde 100mg
An inhibitor of EAAT2 (Ki 23 UM) selective for EAAT2 over EAAT1 and EAAT3 (Ki 3 mM for both) reduces depressive-like behavior in rats in the forced swim test at 5 nmol infused into the infralimbic cortex induces anhedonia-like behavior in rats in a sucrose intake test at 6 25 nmol infused into the PFC impairs memory acquisition consolidation and retrieval in mice in the novel object recognition test
Cayman Chemical SKQ1bromIde 50mg
Inhibits GSK3B more potently (IC50 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s 2 0 and 4 2 UM respectively) stimulates the proliferation of human islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae
Cayman Chemical DomperIdon 100mg
A natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension
Cayman Chemical SBE 13hydrochlorIde 50mg
A positive allosteric modulator of mGluR5 (EC50s 0 17 and 0 23 M for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures respectively) selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 at 10 M decreases the conditioned avoidance response apomorphine-induced climbing as well as PCP- apomorphine- and amphetamine-induced locomotor activity in rats in a dose-dependent manner improves recall in a novel object recognition test and reduces impulsivity in the 5CSRTT from 0 1-50 mg/kg enhances reversal learning in mice in the Morris water maze test
Cayman Chemical ArachIdIc AcIdodIum salt 100mg
A PARP inhibitor (IC50 0 2 and 0 24 UM for PARP1 and PARP2 respectively in nuclear rat brain extracts) selective for PARP over GAPDH ADH or LDH has no effect on lipid peroxidation prevents cell death in vitro and in vivo
Cayman Chemical IsotretInoIn 50mg
A polyketide that serves as a precursor for many different antibiotic and anticancer agents
Cayman Chemical VulpInIc AcId 100mg
A lignan with diverse biological activities inhibits polymerization of isolated chicken brain tubulin (IC50 0 6 UM) induces mitotic arrest at the G2/M phase in CCRF CEM cells from 0 01 to 5 Ug/ml is protective against HSV-1 infection in Vero cells at 5 UM inhibits proliferation of several DLBCL cell lines (IC50s 0 0098-0 017 UM) a starting material in the semisynthesis of etoposide and teniposide
Cayman Chemical EsmololhydrochlorIde 100mg
Inhibits necroptosis by blocking MLKL a key substrate of RIP3