Human Sera
Cayman Chemical Cabergoln 50mg
A potent and selective dopamine D2 receptor agonist (Kis = 0.912 and 6,935 nM for D2 and D1 receptors, respectively, in rat striatum); inhibits PRL secretion in and growth of rat pituitary tumor cells in a concentration-dependent manner; suppresses the mTOR signaling pathway in a time-dependent manner and induces autophagy and cell death in MMQ and GH3 rat pituitary cells; stimulates motor activity and decreases dyskinesias in a monkey model of MPTP-induced Parkinson's disease when administered at a dose of 0.25 mg/kg
Cayman Chemical -GalocatechIn 50mg
A polyphenol and flavonoid that has diverse biological activities; inhibits adherence of P. gingivalis onto human buccal epithelial cells by >50% at 250 μg/ml; has antimutagenic properties in UV-irradiated E. coli cells; inhibits cell death induced by D-galactosamine and TNF-α in primary cultured mouse hepatocytes by 29.9% at 80 μM; inhibits HCT116 colorectal cancer cell proliferation by 57% at 100 μM
Cayman Chemical Butenoyl PAF 50mg
A product of the oxidative decomposition of 2-arachidonoyl phospholipids; 10-fold less potent than PAF as a PAF receptor agonist, but present in amounts 100-fold greater
Abcam Tigecycline, Glycylcycline antibiotic, 5MG
MW 585.6 Da, Purity >99%. Glycylcycline antibiotic. Active against Gram-negative and Gram-positive bacteria. Active in vivo. Active against multi-drug resistant pathogens.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical PIperacetazIn 100mg
A typical antipsychotic; inhibits spontaneous motor activity and responding for food in rats, as well as potentiates hexobarbital-induced narcosis in mice; inhibits lysosome acidification, as well as viral entry (IC50 = <8.5 µM), in Ebola-infected Huh7 cells
Cayman Chemical TIrapazamIn 100mg
A hypoxia-activated anticancer agent; is converted to an oxidizing radical under hypoxic conditions; can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity; induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively); induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions; sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model; sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model at (0.08 mmol/kg)
Cayman Chemical PhysostIgmInsalIcylate 50mg
An alkaloid and cholinergic agent; inhibits AChE (IC50 = 0.67 nM); inhibits ChE and increases vagal stimulation-induced ACh output in isolated chicken heart at 10 µM; induces decentralized lower eyelid contractions and increases blood pressure in anesthetized rats at 200 and 400 UG/kg
Cayman Chemical MaduramIcInamonIum salt 100mg
A polyether ionophore antibiotic; selectively binds to monovalent cations over divalent cations; active against Gram-positive bacteria (MICs = 0.9-125 UG/ml); reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively); reduces P. berghei transmission in a mouse model of malaria at 4 and 8 mg/kg; reduces the severity of lesions and completely protects chicks against mortality in a model of E. tenella-induced coccidiosis at 5-10 ppm in the diet
Cayman Chemical 2AmIno3methylImIdazo4 5f 50mg
A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; induces formation of single-base substitutions and exon deletions and increases cell death in vitro; increases incidence of squamous cell hyperplasias in the stomach of p53 knockout mice; increases hepatocellular lesions in female mice regardless of p53 status
Cayman Chemical LIFITEGRAST 50MG
An inhibitor of the LFA-1/ICAM-1 interaction; binds to LFA-1 and blocks the adhesion of Jurkat T cells or HuT 78 cells to ICAM-1 (IC50s = 2.98 and 9 nM, respectively) and inhibits secretion of various cytokines from these cells; increases tear production in dogs with idiopathic keratoconjunctivitis sicca; topical application inhibits LFA-1-dependent neutrophil recruitment to the eye in mouse models of contact lens-associated corneal inflammation induced by corneal abrasion and tobramycin-killed bacteria
Cayman Chemical BenzetImIdehydrochlorIde 50mg
A muscarinic acetylcholine receptor antagonist; induces mydriasis and inhibits pilocarpine-induced salivation and lacrimation in rats (ED50s = 0.06 and 0.04 mg/kg, respectively)
Cayman Chemical TalnIflumate 50mg
A prodrug form of niflumic acid; decreases the rate of chloride/bicarbonate exchange in isolated mouse intestinal villous epithelial cells at 100 µM; dietary administration increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome at 88 mg/kg
Cayman Chemical PIMECROLIMUS 100MG
A macrolactam that binds to macrophilin-12 and inhibits calcineurin as well as prolyl isomerase; the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) and suppresses the generation of pro-inflammatory cytokines; used in countering inflammatory skin diseases, such as eczema and psoriasis
Cayman Chemical BYK 191023hydrochlorIde 50mg
A selective iNOS inhibitor (IC50s = 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively); inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 μM, respectively); suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 μmol/kg per hour); prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia at 50 μmol/kg per hour; increases mean arterial pressure and renal blood flow in a sheep model of septic shock
Cayman Chemical Indacaterol 50mg
A long-acting β2-adrenergic receptor agonist (EC50 = 8.71 nM for increasing intracellular cAMP levels in vitro); selective for β2-ARs over β1- and β3-ARs (Kis = 43.6, 616.6, and 3,311.3 nM, respectively); inhibits 5-HT-induced bronchoconstriction in conscious guinea pigs with a maximal effect of 85% at 6.7 UG/kg intratracheally; inhibits methacholine-induced bronchoconstriction in rhesus monkeys with a maximal effect of 75% at 12.5 mg/kg via nebulization