Human Sera
Cayman Chemical ProtrIptylInhydrochlorIde 50mg
A tricyclic antidepressant; binds to the norepinephrine and 5-HT transporters (Kd = 1.41 and 19.6 nM, respectively); binds to histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively); inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 μM); inhibits food-induced cataplexy in narcoleptic dogs at 1 mg/kg, i.v.
Cayman Chemical R-Lnsoprazole 100mg
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM
Cayman Chemical N-AcetylserotonIn 100mg
The immediate precursor of melatonin that is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase; acts as an agonist at the melatonin receptors MT1, MT2, and MT3
Cayman Chemical MonbromobImn 100mg
A thiol-reactive fluorogenic probe; used to evaluate or quantify a variety of compounds containing reactive sulfur or thiol groups, including H2S, glutathione, proteins, and nucleotides
Cayman Chemical AmIfostInhydrate 50mg
A prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities; used to selectively reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents
Cayman Chemical MozavaptnhydrochlorIde 100mg
A vasopressin V2 receptor antagonist (Ki = 9.42 nM in HeLa cells expressing the human receptor); selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes, respectively; increases urine volume and decreases urine osmolality in rats from 10-30 mg/kg
Cayman Chemical ArtIcaInhydrochlorIde 100mg
An amide local anesthetic most commonly used in dentistry; it possesses a unique ester side chain that is metabolized rapidly by circulating esterases
Cayman Chemical CefamndolesodIum salt 100mg
A cephalosporin antibiotic that is effective against E. coli (MIC values range from 0.25-2 mg/L depending on strain) as well as H. influenza and S. aureus
Cayman Chemical LasofoxIfentartrate 50mg
A third-generation SERM that selectively binds to human ERα (IC50 = 1.5 nM) and inhibits bone loss in ovariectomized rats; used in the treatment of postmenopausal osteoporosis and ER-positive breast cancer; also acts as an inverse agonist at the CB2 cannabinoid receptor
Cayman Chemical GBR 12935hydrochlorIde 50mg
An inhibitor of dopamine uptake; binds to the dopamine transporter (Kd = 27.2 nM); selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively); it increases locomotor activity in mice at 10 mg/kg; induces gnawing in mice (ED50 = 17.1 mg/kg)
Cayman Chemical OxcarbazepIn 100mg
A prodrug form of 10,11-dihydro-10-hydroxy carbamazepine; inhibits high-frequency repetitive firing of rat spinal cord neurons at 1 µM; protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as PTZ- or picrotoxin-induced seizures in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively)
Cayman Chemical NaloxonhydrochlorIde 50mg
An analytical reference standard categorized as an opioid antagonist; formulations containing it have been used as antidotes for opioid overdose and the prevention of overdose; formulations containing it have also been used in the treatment of opiate addiction and in pain management; intended for research and forensic applications
Cayman Chemical R-Lnsoprazole 50mg
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM
Cayman Chemical Docosattraenyl EthnlamID 50mg
An endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA; acts on CB1 receptors with a potency and efficacy similar to that of AEA but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated
Cayman Chemical TIlmIcosInphosphate 50mg
A macrolide antibiotic; active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM); inhibits bacterial protein synthesis (IC50 = 0.36 µM); increases serum CK, CK-MB, and MDA levels in mice, indicating cardiotoxicity