Human Sera
Cayman Chemical OrbIfloxacIn 50mg
A fluoroquinolone antibiotic used in animals, including dogs, cattle, and swine, to combat gastrointestinal and respiratory infections
Cayman Chemical EdrophonIumchlorIde 100mg
An AChE inhibitor (Kis = 0.2 - 0.4 µM) that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site; used as part of a battery of pharmacological tests to confirm a diagnoses of myasthenia gravis
Cayman Chemical FlupIrtInmaleate 100mg
An activator of Kv7/KCNQ; induces relaxation of preconstricted pulmonary arteries isolated from wild type and SERT+ mice; decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension at 30 mg/kg per day; increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg; increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine; indirectly antagonizes NMDA receptors via its effects on potassium channels
Cayman Chemical DImaprIthydrochlorIde 100mg
A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner
Cayman Chemical TerazosInhydrochlorIde 100mg
A potent and selective α1-AR antagonist; selective for α1-AR (Kis = 3.28, 0.68, and 1.09 for α1A-, α1B- and α1D-ARs, respectively) over α2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively); decreases blood pressure in spontaneously hypertensive rats when administered at 0.1-30 mg/kg
Cayman Chemical In vItro Screeng for DrugI 96
A RIPK1 inhibitor (IC50s 16 and 2500 nM for the human and mouse enzymes respectively) 10000-fold selective for RIPK1 over a panel of 339 kinases at 10 UM inhibits necrotic cell death induced by a combination of TNF-a and the caspase inhibitor QVD-OPh in U937 human monocytic and L929 murine fibrosarcoma cells (IC50s 6 3 and 1300 nM respectively) decreases IL-1B and IL-6 levels in intestinal mucosa tissue isolated from patients with ulcerative colitis at 3-300 nM increases survival in a mouse model of TNF-a-induced lethal shock at 3 10 and 50 mg/kg
Cayman Chemical 1MethylhIstamInhydroCLOr 100mg
A major metabolite of histamine used as a biomarker of histaminergic system activity via CSF levels in Alzheimer’s disease patients
Cayman Chemical BrImonIdIntartrate 50mg
An α2-AR agonist (Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells); selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain); lowers intraocular pressure in DBA/2J mice to control levels at 0.1% applied topically to the eye; protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia at 1 mg/kg per day
Cayman Chemical MoguIsteIn 100mg
A peripherally acting antitussive agent; inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively); prevents BALF eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation; inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs at 30 mg/kg
Cayman Chemical trns-ZeatIn RIbosIde 50mg
A cytokinin; suppresses hypocotyl adventitious root formation in cucumber plants from 0.001-1 µM; increases the activity of SOD, APX, CAT, and POD in the leaves, as well as improves turf quality and delays leaf wilting in a creeping bentgrass model of drought stress at 10 µM
Cayman Chemical Longspur epmdum Epmedn B 50mg
A flavonoid glycoside; scavenges DPPH radicals in a cell-free assay (IC50 = 107.9 µM); increases proliferation of UMR-106 osteoblasts by 24.9 and 36.3% at 10 and 100 µM, respectively; prevents prednisolone-induced osteoporosis in zebrafish at 1 µM; inhibits TPA-induced EAr edema in mice (ED50 = 114 nmol/ear)
Cayman Chemical HypaconItIn 50mg
A diterpene alkaloid with diverse biological activities; inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM); prevents carrageenan-induced paw edema in mice at 0.025 mg/kg; reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg); toxic to mice (LD50 = 1.9 mg/kg, s.c.)
Cayman Chemical CarbetapentncItrate 100mg
A σ1 receptor agonist (Ki = 10.4 nM); inhibits citric acid-induced cough in guinea pigs from 1-5 mg/kg; reduces the number of seizures, mortality, and hippocampal neuronal cell death in a rat model of kainate-induced seizures at 12.5 and 25 mg/kg
Cayman Chemical ArtIcaInhydrochlorIde 50mg
An amide local anesthetic most commonly used in dentistry; it possesses a unique ester side chain that is metabolized rapidly by circulating esterases