Human Sera
Cayman Chemical TolbutamIde 50mg
A bioactive saponin used in traditional Chinese medicine has diverse protective effects for the cardiovascular immune digestive and nervous systems
Cayman Chemical Sulfamoxole 50mg
A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp also accumulates within mitochondria and can inhibit oxidative phosphorylation ex/em 507/529 nm
Cayman Chemical Indacaterol 50mg
An ALK1 and ALK2 inhibitor (IC50s 1 8 and 1 1 nM respectively) that can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 100 nM) without affecting TGF-B signaling less selective for ALK3 4 5 and 6 subtypes and the type II BMP receptor ActRIIA (IC50s 34 4 302 321 6 4 and 220 nM respectively)
Cayman Chemical LevobunololhydrochlorIde 100mg
An NRTI reduces HIV-1 p24 antigen levels in the culture supernatant of human peripheral blood lymphocytes infected with laboratory-adapted HIV-1 strains (IC50s 0 0025-0 09 UM) inhibits syncytium formation between various CD4 cell lines and several strains of HIV-1 or HIV-2 (IC50s 0 014-0 61 UM) reduces serum viral titers in a woodchuck model of chronic HBV infection at 40 or 200 mg/kg
Cayman Chemical SKF 38393hydrobromIde 100mg
A chemokine receptor CCR2 antagonist (IC50 0 36 UM) inhibits the related CCR1 receptor with an IC50 value of 17 8 UM and inhibits adrenergic a1a a1d and 5HT1A receptors with IC50 values of 0 13 0 32 and 47 UM respectively
Cayman Chemical 14-PentadecenoIc AcId 100mg
A cell-permeable selective and reversible inhibitor of Syk (IC50 41 nM) prevents Fc RI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID50 13 2 mg/kg s c )
Cayman Chemical ArIpIprazole 50mg
An ester derivative of fluprostenol a potential inactive metabolite of fluprostenol isopropyl ester (travoprost) a potential impurity found in commercial preparations of fluprostenol isopropyl ester
Cayman Chemical Chrysophnol 100mg
An ester derivative of fluprostenol a potential prodrug to 9-keto fluprostenol a potential metabolite of fluprostenol isopropyl ester (travoprost)
Cayman Chemical EmetInhydrochLRIde hydrat 50mg
A selective partial agonist of B3-adrenergic receptors (EC50s 0 43 580 and 10000 nM for activation of B3- B1- and B2-adrenoceptors respectively)
Cayman Chemical tremIfencItrate 100mg
A mycotoxin produced by fungi of the Fusarium genus that is phytotoxic to various agriculture grain crops cardiotoxic to poultry and rats and cytotoxic to human red blood cell progenitors (IC50 4 1 M)
Cayman Chemical Pperaqun 50mg
A peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases including MMP-1 (Ki 300 nM) MMP-3 (Ki 1700 nM) MMP-8 (Ki 130 nM) and MMP-9 (Ki 330 nM) also targets peptide deformylase and meprin a (Ki 20 nM)
Cayman Chemical Chrysophnol 50mg
A potent inhibitor of JAK2 that also inhibits the JAK2V617F mutant enzyme (IC50s for both enzymes 0 5 nM) orally bioavailable with a long half-life in vivo suppressing leukemic cell spreading and splenomegaly in JAK2V617F cell-driven disease in mice
Cayman Chemical tremIfencItrate 50mg
A selective antagonist of CCR2 (IC50s 89 nM) inhibits MCP-1-stimulated chemotaxis (IC50 330 nM) and ischemia-reperfusion injury in kidneys
Cayman Chemical EmetInhydroCLOrID hydrat 100mg
A synthetic analog of retinoic acid that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki 540 UM)