Human Sera
Cayman Chemical 3 4-EDMAhydrochlorIde 50mg
An analog of 3,4-MDMA that stimulates the release of serotonin and dopamine from rat brain synaptosomes at 1 µM
Cayman Chemical MedetomIdInhydrochlorIde 50mg
An α2-AR agonist (Ki = 1.08 nM); selective for α2-ARs over α1-ARs (Ki = 1,750 nM); induces sedation in dogs
Cayman Chemical MoxIfloxacInhydrochLRIde 100mg
A fluoroquinolone antibiotic; active against 390 clinical isolates of various bacteria (MIC90s = ≤0.25 UG/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 UG/ml, respectively); an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays); prevents S. aureus- and P. aeruginosa-induced increases in BALF neutrophil infiltration and reduces S. aureus- and P. aeruginosa-induced increases in lung CXCL1 and IL-1β levels in mouse models of bacterial pneumonia at 100 mg/kg twice per day for two days; decreases the number of lung and spleen CFUs in a mouse model of systemic M. tuberculosis infection at 100 mg/kg
Cayman Chemical R-DeprenylhydrochlorIde 100mg
A selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM); may ameliorate depression, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke
Cayman Chemical GardIquImod 50mg
A selective agonist of human TLR7; enhances the immunosuppressive activity of Treg cells at 0.5 to 2 UG/ml
Cayman Chemical 9-EthylgunIn 100mg
A model nucleobase that is used to study DNA interactions with organometallic complexes, especially those designed to target tumors
Cayman Chemical Pregnolon CarbonItrIle 100mg
A catatoxic steroid that acts as an agonist of the rodent PXR at µM concentrations; mediates induction of hepatic CYP3A, Oatp2, and Cyp7a1, regulating both xenobiotic and bile acid homeostasis
Cayman Chemical UDPNacetylDGlucosamIns 50mg
A nucleotide sugar that is used by glycosyltransferases to transfer N-acetylglucosamine residues to substrates
Cayman Chemical TIotropIumbromIde 50mg
An antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors); decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner; confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs at 1.0 g/L inhaled aerosol
Cayman Chemical VardenafIlhydroCLOrID hyd 50mg
An inhibitor of PDE5 (IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM); selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively); improves erectile dysfunction in a rat model of acute arteriogenic erectile dysfunction; reduces the latency to mount and increases the frequency of mounting in mice after chronic treatment at 2 mg/kg for five weeks
Cayman Chemical CepharnthIn 50mg
A biscoclaurine alkaloid that can decrease the fluidity of biological membranes; exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models
Cayman Chemical PaeonIflorIn 100mg
A monoterpene glycoside that has analgesic and anti-inflammatory actions in mice
Cayman Chemical PIzotIfenmalate 100mg
A triptan with high affinity for serotonin and dopamine receptors (Kis = 7.94 and 2.4 nM for 5-HT2C and D2, respectively)
Cayman Chemical NaphthofluoresceIn 50mg
A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP, resulting in decreased levels of active MT1-MMP; inhibits the invasion of Matrigel by the human fibrosarcoma cell lines HT1080
Cayman Chemical DapIprazolehydrochlorIde 50mg
An α-AR antagonist; inhibits norepinephrine-induced contractions in rat vas deferens, guinea pig spleen, and rat aorta, regions that express high levels of α1A-AR, α1B-AR, and α1D-ARs, respectively (pA2s = 7.93, 7.13, and 8.26, respectively); inhibits histamine-, angiotensin II-, pentagastrin-, carbachol, and serotonin-induced contractions in guinea pig ileum in a dose-dependent manner; reverses pupil dilation induced by the combination of phenylephrine and tropicamide in rabbits