Human Sera
Cayman Chemical ScutelareIn 50mg
A flavone; has antioxidant activity in a TRAP assay at 1 μg/ml; inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the SARS coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively); decreases LPS-induced NO release and iNOS and TNF-α mRNA expression in RAW 264.7 macrophages at 50 μM; decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model at 0.5 μg/g
Cayman Chemical PergolIdemesylate 50mg
A dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors); depresses dopaminergic firing in paralyzed rats (ED50 = 50 = 0.4 mg/kg)
Cayman Chemical DefensamIde 100mg
An SPHK1 activator; increases S1P levels in primary human keratinocytes but does not affect S1P lyase activity in the same cells at 100 µM; increases protein levels of LL-37 in primary human keratinocytes at 100 µM; inhibits invasion of S. aureus into murine skin ex vivo; has been used as an intermediate in the synthesis of sinuxylamide A as well as compounds with anticancer and antibacterial activities
Cayman Chemical MaytnsInol 100mg
An ansa macrolide; inhibits polymerization and induces depolymerization of bovine brain tubulin (EC50s = 12 and 43 µM, respectively); inhibits sea urchin egg mitosis at 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 UG/ml)
Cayman Chemical SmethylLThIocItrulInhy 100mg
S-methyl-L-Thiocitrulline is a potent NOS inhibitor with selectivity toward the neuronal isoform compared to eNOS and iNOS. For human enzymes, it exhibits Ki values of 1.2, 11, and 40 nM for nNOS, eNOS, and iNOS, respectively.{1325,1293}
Cayman Chemical Nmethyl2AIhydrochLRIde 50mg
An AI that reduces nociception and inhibits exploratory in mice; intended for forensic and research purposes
Cayman Chemical LnIfIbrnor 50mg
A PPAR agonist (EC50s = 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively); increases β-oxidation in Huh-7 and C2C12 cells at 1 and 3 µM, respectively; reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes at 10 and 30 mg/kg for five days; increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of NASH
Cayman Chemical 3 6-DIsInapoylsucrose 50mg
An oligosaccharide ester with antidepressant- and anxiolytic-like activities; prevents increases in serum cortisol levels, serum SOD activity, and brain MAO-A and MAO-B levels, as well as decreases serum MDA levels, in a rat model of chronic mild stress; increases sucrose consumption in the sucrose preference test, indicating antidepressant-like activity, in the same model at 20 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, from 3 to 12 mg/kg
Cayman Chemical 2DeoxycytIdIn5OtrIphos 50mg
A nucleoside triphosphate; has commonly been used in PCR reaction mixtures as a substrate for DNA synthesis by DNA polymerases
Cayman Chemical NaBenzoylLArgInInpNAhy 100mg
A colorimetric substrate for trypsin and papain; enzymatic cleavage releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of trypsin or papain activity
Cayman Chemical EuphorbIasteroId 100mg
A tricyclic diterpene; inhibits EArly-stage adipogenesis of 3T3-L1 cells at 25 and 50 µM; inhibits proliferation of HL-60 cells in a concentration-dependent manner, as well as induces apoptosis and increases the expression of Fas and Fas ligand (FasL) and the activity of caspase-3 and caspase-8 in HL-60 cells; increases P-glycoprotein activity, reverses multi-drug resistance, and restores cytotoxicity of vinblastine, paclitaxel, and doxorubicin to MES/SA/Dx5 sarcoma cells
Cayman Chemical RIfapentIn 100mg
A long-lasting rifamycin antibiotic that is effective against Mycobacterium species, including M. tuberculosis as well as experimental infections caused by S. aureus, S. pyogenes group A, S. pneumoniae, and K. pneumoniae
Cayman Chemical S-PhenylmercapturIc AcId 50mg
A metabolite of benzene; used as a biomarker for benzene exposure; urinary concentrations up to 543 UG/g creatinine have been detected
Cayman Chemical CarbIdopahydrate 100mg
A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo
Cayman Chemical 4NItrophenyl DXylopyrnos 100mg
A chromogenic β-xylosidase substrate; upon hydrolysis by β-xylosidase, 4-nitrophenol is released, which can be quantified by colorimetric detection at 405 nm as a measure of β-xylosidase activity