Human Sera
Cayman Chemical RupatdInfumarate 50mg
A histamine H1 and PAF receptor antagonist; binds to rabbit platelet membranes and guinea pig cerebellum membranes (apparent Kis = 0.55 and 0.1 µM, respectively, in radioligand binding assays); inhibits histamine-induced contraction of isolated guinea pig ileum (pA2 = 9.29) and PAF-induced platelet aggregation in washed rabbit platelets (pA2 = 6.68); prevents histamine- or PAF-induced hypotension in rats (ID50s = 1.4 and 0.44 mg/kg, respectively); reverses histamine- or PAF-induced bronchoconstriction in guinea pigs (ID50s = 113 and 9.6 mg/kg, respectively)
Cayman Chemical 8- 3-ChlorostyrylcaffeIn 50mg
An adenosine A2 receptor antagonist (Ki = 54 nM); selective for adenosine A2 over A1 receptors (Ki = 28 µM); reverses APEC-induced locomotor depression in mice (ED50 = 16 UG/kg, i.p.); increases locomotion in mice at 5 mg/kg; reverses L-DOPA-induced shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels in a rat model of 6-OHDA-induced Parkinson's disease at 5 mg/kg; inhibits MAO-B (Ki = 100 nM); reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice
Cayman Chemical PIzotIfenmalate 100mg
A triptan with high affinity for serotonin and dopamine receptors (Kis = 7.94 and 2.4 nM for 5-HT2C and D2, respectively)
American Research Products Inc Human 6 hydroXymelatonin sulfa
Human 6-hydroXymelatonin sulfate (6HMS) ELISA kit from CUSABIO Detection Range 10 pg/mL- 400 pg/mL Sensitivity 10 pg/mL Sample serum plasma tissue homogenates Method Competitive
Cayman Chemical AbIrateron Acetate 50mg
A CYP17A1 inhibitor (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17α-hydroxylase activities, respectively); prodrug form of abiraterone; reduces plasma testosterone levels, increases plasma luteinizing hormone levels, and reduces ventral prostate, seminal vesicle, testis, and kidney weight in mice at 0.1 and 0.5 mmol/kg per day; reduces SARS-CoV-2 viral load in the culture supernatant of infected Vero E6 cells (EC90 = 8.4 μM) and is active in a plaque reduction assay (EC50 = 1.94 μM)
Cayman Chemical TazobactamsodIum salt 100mg
A β-lactamase inhibitor; inhibits Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC50s = 97, 150, and 8.5 nM) and the class D oxacillinase OXA-2 (IC50 = 10 nM); active against Gram-positive (MIC90s = 2-128 UG/ml) and Gram-negative bacteria (MIC90s = 4-128 UG/ml) when used in combination with piperacillin; potentiates the activity of ceftolozane against Enterobacteriaceae in a neutropenic mouse model of thigh infection
Cayman Chemical Amodaqun 50mg
A prodrug form of N-desethyl amodiaquine; active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine; dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection
Cayman Chemical -nabasInhydrochlorIde 100mg
An alkaloid agonist of nAChRs with teratogenic activity; induces depolarization of TE 671 cells endogenously expressing human fetal muscle-type nAChRs (EC50 = 10.1 µM); binds to α4β2 subunit-containing nAChRs in K177 cells (Ki = 37.63 nM); teratogenic in vivo, inducing congenital defects, including cleft palate and severe fixed excessive flexure of carpal joints, in piglets when administered to pregnant dams during gestation days 43-53 at a dose of 2.6 mg/kg twice per day
Cayman Chemical -EvodIamIn 100mg
A natural indole alkaloid with demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions; an AhR antagonist (Ki = 28 nM), activator of TRPV1 (EC50 = 45 nM), and inhibitor of signaling through NF-κB
Cayman Chemical TomatIdInhydrochlorIde 50mg
A steroidal alkaloid with diverse biological activities; suppresses NF-κB signaling as well as iNOS and COX-2 expression in LPS-stimulated macrophages; inhibits acid sphingomyelinase activity at 10 mM; preferentially blocks replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 UG/ml, respectively); prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice; has been used as a negative control for cyclopamine in studies involving signaling mediated by the hedgehog pathway
Cayman Chemical DIbutyrylCyclIc GMPsodIum 50mg
A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase
Cayman Chemical OclacItInIb 50mg
A JAK family kinase inhibitor (IC50s = 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively); selective for JAK kinases over a panel of 38 additional kinases at 1 μM; inhibits LPS-induced increases in IL-12 and TNF-α levels in murine BMDCs in a concentration-dependent manner; topical administration reduces scratching behavior and EAr edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in EAr skin, in a mouse model of TDI-induced allergic dermatitis at 0.1, 0.25, and 0.5%
Cayman Chemical E-5- 2-BromovInyluracIl 100mg
A pyrimidine base; is an inactive metabolite of the antiviral agents sorivudine and BVDU that may be regenerated to BVDU in vivo; irreversibly inactivates DPD in an NADPH-dependent manner; enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-FU in a P388 murine leukemia model at 200 µmol/kg, increasing survival time