Human Sera
Cayman Chemical nastrozole 100mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical DesloratdIn 100mg
A histamine H1 receptor antagonist (Ki = 0.97 nM) and an active metabolite of loratadine; inhibits calcium flow in neurons and glia in vitro (IC50s = 9.177 and 0.3185 µM, respectively) in a 5-HT2A receptor-dependent manner; reduces ovalbumin-induced sneezing, nose rubbing, eye watering, and congestion in ovalbumin-sensitized guinea pigs at 10 mg/kg; increases the clearance of amyloid-β by microglia and reverses learning and memory deficits in the Morris water maze in the APP/PS1 mouse model of Alzheimer’s disease at 20 mg/kg per day
Cayman Chemical Tenatoprazole 50mg
A proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM; blocks induced gastric acid secretion and ulcer formation in rats and humans
Innovative Research Inc Single Donor Human Lung Cancer Serum
Single Donor Human Lung Cancer Serum from Innovative Research is whole blood derived. Available volumes are variable, and range from 0.5ml to 1.0ml per vial (you can select your exact samples from our inventory, if desired). A detailed patient history and clinical information is recorded at the time of draw, and multiple samples and plasma/serum matched sets from the same donor are often available.
Innovative Research Inc Single Donor Human Breast Cancer Serum
Single Donor Human Breast Cancer Serum from Innovative Research is whole blood derived. Available volumes are variable, and range from 0.5ml to 1.0ml per vial (you can select your exact samples from our inventory, if desired). A detailed patient history and clinical information is recorded at the time of draw, and multiple samples and plasma/serum matched sets from the same donor are often available.
Innovative Research Inc Single Donor Human Alzheimer's Serum
Single Donor Human Alzheimer's Serum from Innovative Research is whole blood derived. Available volumes are variable, and range from 0.5ml to 1.0ml per vial (you can select your exact samples from our inventory, if desired). A detailed patient history and clinical information is recorded at the time of draw, and multiple samples and plasma/serum matched sets from the same donor are often available.
Cayman Chemical Gncclovr 50mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical PXS-5505hydrochlorIde 50mg
A pan inhibitor of LOX and LOXL1-4 (IC50s = 0.493, 0.159, 0.57, 0.18, and 0.19 µM for fibroblast LOX and recombinant human LOXL1-4, respectively); selective for LOX and LOXL1-4 over DAO, VAP-1, MAO-A, and MAO-B (IC50s = >30 µM for all); reduces bleomycin-induced increases in dermal thickness and the levels of α-smooth muscle actin in a mouse model of systemic sclerosis at 15 mg/kg; reduces collagen crosslinking in KPC CAF 3D organotypic matrices; increases survival to a greater extent than gemcitabine alone when administered in combination with gemcitabine, reduces gemcitabine-induced increases in collagen levels and stiffness, and reduces liver metastatic burden in autochthonous KPC pancreatic ductal adenocarcinoma mouse models at 20 mg/kg
Cayman Chemical 4-AcetamIdo ntIpyrIn 50mg
An active metabolite of metamizole; inhibits β-galactosidase activity, a marker of LXRα activity, in a yeast two-hybrid assay (IC20 = 79.9 µM); has been found as a micropollutant in reclaimed wastewater
Cayman Chemical ArachIdIc AcId 100mg
A long-chain saturated fatty acid; inhibits N-formyl-Met-Leu-Phe-induced neutrophil aggregation at 5 μM
Cayman Chemical Hexnoyl GlycIn 100mg
An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation
Cayman Chemical Daursoln 50mg
An alkaloid with diverse biological activities; enhances camptothecin-induced cytotoxicity in HeLa cells at 10 µM; inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively); inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM); prolongs APD and reduces EADs in papillary muscle preparations isolated from hypertrophied rabbit hearts at 15 µM
Cayman Chemical Broprmn 50mg
An immunomodulator with diverse biological activities; a TLR7 agonist that inhibits RANKL-induced osteoclast differentiation of murine BMDMs; dietary administration prevents development of TCCs in a mouse model of carcinogen-induced bladder carcinoma at 200 mg/kg twice per week; reduces pulmonary collagen accumulation and BALF monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis at 100 mg/kg; delays disease onset and progression and increases plasma IFN levels in a mouse model of EAE
Cayman Chemical 1OOctadecyl2Omethylsng 100mg
A metabolite of a phosphotidylinositol ether lipid analog known to target the pleckstrin homology domain of Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity