Guinea Pig Whole Blood
Cayman Chemical Pamoc Acd 50g
A potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay); induces GPR35 translocation from the plasma membrane to the cytoplasm (EC50 =22 nM); increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a; has antinociceptive effects in a mouse abdominal constriction model of visceral pain perception (ED50 = 40.5 mg/kg)
Cayman Chemical ArachIdonIc ACD sulfonatS
An α-sulphonated version of arachidonic acid that may possess improved lipophilicity
Cayman Chemical Linolenic ACD ethyl ester 1g
An esterified version of GLA which is less water soluble but more amenable for the formulation of GLA-containing diets
Cayman Chemical Tannc Acd 25g
An inhibitor of the gastric H /K ATPase and an enantiomer of esomeprazole inhibits histamine-induced acid secretions in isolated rabbit gastric glands (IC50 781 UM) to a lesser extent than esomeprazole inhibits histamine-induced stomach acid secretion in rats at 30 mg/kg
Cayman Chemical PRfluorotetradecnoIc ACD 500mg
An antagonist of mGluR1 and mGluR2 selective for mGluR1 and mGluR2 over mGluR6 at 1 mM inhibits L-glutamate-induced increases in InsPs in CHO cells expressing mGluR1 and prevents forskolin-induced decreases in cAMP in CHO cells expressing mGluR2 at 1 mM intraplantar administration reduces glutamate-induced paw licking in a mouse model of nociceptive pain at 1-10 nmol/paw
Cayman Chemical Tannc Acd 5g
An a1-AR (IC50 3200 nM) and a2-AR antagonist (Kis 112 1230 354 and 173 nM for a2A a2B- a2C- and a2D-ARs respectively) inhibits a-AR agonist-induced contractions in isolated human corpus cavernosum smooth muscle (IC50 0 1 UM) lowers vascular resistance in norepinephrine-preconstricted IPPSFs (EC50 288 nM)
Cayman Chemical Tannc Acd 10g
An orally bioavailable selective inhibitor of PDGFRa PDGFRB and FLT3 (IC50s 11 3 2 and 4 nM respectively) also inhibits mutant forms of these kinases including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3 at nanomolar concentrations