Antibodies
Antibodies are glycoproteins that serve an essential role in the immune system to protects animals from infection, or the cytotoxic effects of foreign compounds, by binding with high affinity to invasive molecules; classified as primary or secondary.
Primary Antibodies
(1,666,839)
Secondary Antibodies
(76,923)
Isotype Controls and Standards
(8,571)
Antibody Panels and Kits
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Invitrogen™ Lamin B1 Recombinant Superclonal™ Antibody (10HCLC)
Invitrogen™ Lamin B1 Recombinant Superclonal™ Antibody (10HCLC)
Rabbit Recombinant Superclonal Antibody
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| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human,Mouse |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | ChIP Assay,Immunohistochemistry (Paraffin),Western Blot,Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | P14733, P20700 |
| Isotype | IgG |
| Concentration | 0.5 mg/mL |
| Antigen | Lamin B1 |
| Gene Symbols | Lmnb1 |
| Regulatory Status | RUO |
| Purification Method | Protein A |
| Gene Alias | 0710005A05Rik; ADLD; C-flanking peptide of NPY; CPON; fc06g01; I79_003938; lamin B1; lamin B1 L homeolog; lamin B1 protein; lamin-b; lamin-B1; Lamin-L(I); LMN; LMN2; LMNB; LMNB1; lmnb1 protein; lmnb1.L; MGC111419; Neuropeptide tyrosine; Neuropeptide Y; NPY; NPY02; prepro-neuropeptide Y; pro-neuropeptide Y; PYY4; RATNPY; RATNPY02; unnamed protein product; wu:fc06g01; XELAEV_18007951mg |
| Gene | Lmnb1 |
| Product Type | Antibody |
| Gene ID (Entrez) | 16906, 4001 |
| Formulation | PBS with 0.09% sodium azide; pH 7.4 |
| Immunogen | Peptides corresponding to human Lamin B1 [1) aa62-aa79 2) aa450-aa467]. |
| Classification | Recombinant Superclonal |
| Primary or Secondary | Primary |
| Clone | 10HCLC |
CD62L (L-Selectin) Monoclonal Antibody (MEL-14), Brilliant Ultra Violet™ 615, eBioscience™, Invitrogen™
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Rat Monoclonal Antibody
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| Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
|---|---|
| Target Species | Mouse |
| Host Species | Rat |
| Conjugate | Brilliant Ultraviolet 615 |
| Applications | Flow Cytometry |
| Form | Liquid |
| Isotype | IgG2a κ |
| Gene Accession No. | P18337 |
| Concentration | 0.2 mg/mL |
| Antigen | CD62L (L-Selectin) |
| Gene Symbols | SELL |
| Regulatory Status | RUO |
| Purification Method | Affinity chromatography |
| Gene Alias | A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1 |
| Gene | SELL |
| Product Type | Antibody |
| Gene ID (Entrez) | 20343 |
| Formulation | PBS with BSA and 0.09% sodium azide; pH 7.2 |
| Classification | Monoclonal |
| Primary or Secondary | Primary |
| Clone | MEL-14 |
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Invitrogen™ SMC3 Polyclonal Antibody
Invitrogen™ SMC3 Polyclonal Antibody
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Rabbit Polyclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | ChIP Assay,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot,Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | P97690, Q9CW03, Q9UQE7 |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Antigen | SMC3 |
| Gene Symbols | SMC3 |
| Regulatory Status | RUO |
| Purification Method | Antigen affinity chromatography |
| Gene Alias | Bam; Bamacan; basement membrane chondroitin sulfate proteoglycan; basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; chondroitin sulfate proteoglycan 6; chondroitin sulfate proteoglycan 6 (bamacan); chromosome segregation protein SmcD; Chromosome-associated polypeptide; cspg6; HCAP; im:7142991; mad member-interacting protein 1; Mmip1; SMC protein 3; Smc3; SMC-3; SMC3 protein; SMC3L1; SmcD; structural maintenace of chromosomes 3; structural maintenance of chromosomes 3; structural maintenance of chromosomes protein 3; structural maintenance of chromosomes protein 3-like protein; wu:fb22e01; wu:fc30d07 |
| Gene | SMC3 |
| Product Type | Antibody |
| Gene ID (Entrez) | 13006, 29486, 9126 |
| Formulation | 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human SMC3. The exact sequence is proprietary. |
| Classification | Polyclonal |
| Primary or Secondary | Primary |
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Invitrogen™ Villin Polyclonal Antibody
Invitrogen™ Villin Polyclonal Antibody
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Rabbit Polyclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human,Mouse |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | ELISA,Immunohistochemistry (Paraffin),Western Blot,Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | P09327, Q62468 |
| Isotype | IgG |
| Concentration | 0.36 mg/mL |
| Antigen | Villin |
| Gene Symbols | VIL1 |
| Regulatory Status | RUO |
| Purification Method | Antigen affinity chromatography |
| Gene Alias | D2S1471; OTTHUMP00000207159; Vil; Vil1; villin 1; villin-1 |
| Gene | VIL1 |
| Product Type | Antibody |
| Gene ID (Entrez) | 22349, 7429 |
| Formulation | PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human Villin. The exact sequence is proprietary. |
| Classification | Polyclonal |
| Primary or Secondary | Primary |
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Invitrogen™ TSC2 Monoclonal Antibody (3G9D9)
Invitrogen™ TSC2 Monoclonal Antibody (3G9D9)
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Mouse Monoclonal Antibody
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| Content And Storage | -20°C |
|---|---|
| Target Species | Human |
| Host Species | Mouse |
| Conjugate | Unconjugated |
| Applications | ELISA,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot |
| Form | Liquid |
| Gene Accession No. | P49815 |
| Isotype | IgG1 |
| Concentration | 0.5 mg/mL |
| Antigen | TSC2 |
| Gene Symbols | TSC2 |
| Regulatory Status | RUO |
| Purification Method | Protein A |
| Gene Alias | LAM; Nafld; OTTHUMP00000198394; PPP1R160; protein phosphatase 1, regulatory subunit 160; Rc; renal carcinoma; Tcs2; Tsc2; TSC4; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog |
| Gene | TSC2 |
| Product Type | Antibody |
| Gene ID (Entrez) | 7249 |
| Formulation | PBS with 0.1% sodium azide; pH 7.4 |
| Immunogen | Recombinant human tuberin protein. |
| Classification | Monoclonal |
| Primary or Secondary | Primary |
| Clone | 3G9D9 |
Invitrogen™ CD31 Monoclonal Antibody (MBC78.2), FITC
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Mouse Monoclonal Antibody
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| Content And Storage | 4°C, store in dark |
|---|---|
| Target Species | Human |
| Host Species | Mouse |
| Conjugate | FITC |
| Applications | Flow Cytometry |
| Form | Liquid |
| Gene Accession No. | P16284 |
| Isotype | IgG1 |
| Antigen | CD31 |
| Gene Symbols | Pecam1 |
| Regulatory Status | ASR |
| Purification Method | Purified |
| Gene Alias | C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule |
| Gene | Pecam1 |
| Product Type | Antibody |
| Gene ID (Entrez) | 5175 |
| Formulation | PBS with 4mg/mL BSA and 0.1% sodium azide |
| Immunogen | Human CD31. |
| Classification | Monoclonal |
| Primary or Secondary | Primary |
| Clone | MBC78.2 |
Invitrogen™ MMP16 Recombinant Rabbit Monoclonal Antibody (13H7L7)
Rabbit Recombinant Monoclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human,Rat |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | Flow Cytometry,Immunohistochemistry (Paraffin),Western Blot,Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | O35548, P51512 |
| Isotype | IgG |
| Concentration | 0.5 mg/mL |
| Antigen | MMP16 |
| Gene Symbols | Mmp16 |
| Regulatory Status | RUO |
| Purification Method | Protein A |
| Gene Alias | C8orf57; DKFZp761D112; matrix metallo protease; matrix metallopeptidase 16; matrix metallopeptidase 16 (membrane-inserted); matrix metalloproteinase 16; matrix metalloproteinase-16; Membrane type 3-MMP; membrane-type matrix metalloproteinase 3; Membrane-type-3 matrix metalloproteinase; MMP; MMP-1; Mmp16; MMP-16; MMPs; MMPX2; MMP-X2; Mt3mmp; MT3-MMP; MT-MMP 3; MT-MMP2; MTMMP3; MT-MMP3; Putative transmembrane protein C8orf57 |
| Gene | Mmp16 |
| Product Type | Antibody |
| Gene ID (Entrez) | 4325, 65205 |
| Formulation | PBS with 0.09% sodium azide |
| Immunogen | Recombinant protein corresponding to amino acids 121-545 of human MMP-16. |
| Classification | Recombinant Monoclonal |
| Primary or Secondary | Primary |
| Clone | 13H7L7 |
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Invitrogen™ TTYH2 Polyclonal Antibody
Invitrogen™ TTYH2 Polyclonal Antibody
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Rabbit Polyclonal Antibody
| Content And Storage | Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C |
|---|---|
| Target Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | Immunohistochemistry,Western Blot |
| Form | Liquid |
| Gene Accession No. | Q3TH73, Q9BSA4 |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Antigen | TTYH2 |
| Gene Symbols | TTYH2 |
| Regulatory Status | RUO |
| Purification Method | Antigen affinity chromatography |
| Gene Alias | 1110001A03Rik; C17orf29; hTTY2; mTTY2; Protein tweety homolog 2; RGD1562969; TTYH2; tweety family member 2; tweety homolog 2; tweety homolog 2 (Drosophila) |
| Gene | TTYH2 |
| Product Type | Antibody |
| Gene ID (Entrez) | 117160, 287803, 94015 |
| Formulation | PBS with 0.02% sodium azide |
| Immunogen | A 14 amino acid synthetic peptide near the amino terminus of human TTYH2. |
| Classification | Polyclonal |
| Primary or Secondary | Primary |
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Invitrogen™ Phospho-GSK3 alpha/beta (Tyr279, Tyr216) Recombinant Superclonal™ Antibody
Invitrogen™ Phospho-GSK3 alpha/beta (Tyr279, Tyr216) Recombinant Superclonal™ Antibody
Rabbit Recombinant Superclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human,Mouse |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | Western Blot,Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | P49840, P49841, Q2NL51, Q9WV60 |
| Isotype | IgG |
| Concentration | 0.5 mg/mL |
| Antigen | Phospho-GSK3 alpha/beta (Tyr279, Tyr216) |
| Gene Symbols | GSK3A, GSK3B |
| Regulatory Status | RUO |
| Purification Method | Protein A |
| Gene Alias | 2700086H06Rik; 7330414F15Rik; 8430431H08Rik; C86142; FA; factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 alpha; Glycogen synthase kinase-3 beta; GSK3; GSK-3; GSK-3 alpha; GSK-3 beta; Gsk3a; gsk-3-alpha; Gsk3b; GSK-3beta; GSK3beta isoform; serine/threonine-protein kinase GSK3A; Serine/threonine-protein kinase GSK3B |
| Gene | GSK3A |
| Product Type | Antibody |
| Gene ID (Entrez) | 2931, 2932, 56637, 606496 |
| Formulation | PBS with 0.09% sodium azide; pH 7.4 |
| Immunogen | Peptide corresponding to Human GSK3A, GSK3B (aa 211-220). |
| Classification | Recombinant Superclonal |
| Primary or Secondary | Primary |
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Invitrogen™ CCR3 Recombinant Superclonal™ Antibody (23HCLC)
Invitrogen™ CCR3 Recombinant Superclonal™ Antibody (23HCLC)
Rabbit Recombinant Superclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | P51677 |
| Isotype | IgG |
| Concentration | 0.5 mg/mL |
| Antigen | CCR3 |
| Gene Symbols | CCR3 |
| Regulatory Status | RUO |
| Purification Method | Protein A |
| Gene Alias | b-chemokine receptor; CC chemokine receptor 3; C-C chemokine receptor type 3; C-C CKR-3; C-C motif chemokine receptor 3; CC-CKR3; CC-CKR-3; Ccr3; CCR-3; CD193; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 1,-like 2; chemokine (C-C) receptor 3; CKR3; Cmkbr1l2; CMKBR3; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor; Macrophage inflammatory protein 1-alpha receptor-like 2; MGC102841; MIP-1 alpha RL2; MIP-1 alphaRL2; probable C-C chemokine receptor type 3 |
| Gene | CCR3 |
| Product Type | Antibody |
| Gene ID (Entrez) | 1232 |
| Formulation | PBS with 0.09% sodium azide; pH 7.4 |
| Immunogen | Peptides corresponding to Human CCR3 (aa 337-355, 172-190). |
| Classification | Recombinant Superclonal |
| Primary or Secondary | Primary |
| Clone | 23HCLC |
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Invitrogen™ CPEB2 Polyclonal Antibody
Invitrogen™ CPEB2 Polyclonal Antibody
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Rabbit Polyclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Human,Mouse |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | Western Blot |
| Form | Liquid |
| Gene Accession No. | Q7Z5Q1, Q812E0 |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Antigen | CPEB2 |
| Gene Symbols | CPEB2 |
| Regulatory Status | RUO |
| Purification Method | Antigen affinity chromatography |
| Gene Alias | A630055H10Rik; Cpeb2; CPEB-2; CPE-binding protein 2; CPE-BP2; cytoplasmic polyadenylation element binding protein 2; cytoplasmic polyadenylation element-binding protein 2; hCPEB-2 |
| Gene | CPEB2 |
| Product Type | Antibody |
| Gene ID (Entrez) | 132864, 231207 |
| Formulation | 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CPEB2. The exact sequence is proprietary. |
| Classification | Polyclonal |
| Primary or Secondary | Primary |
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Invitrogen™ Phospho-EGFR (Tyr1086) Polyclonal Antibody
Invitrogen™ Phospho-EGFR (Tyr1086) Polyclonal Antibody
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Rabbit Polyclonal Antibody
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| Content And Storage | -20°C |
|---|---|
| Target Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | ELISA,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry |
| Form | Liquid |
| Gene Accession No. | P00533, Q01279 |
| Isotype | IgG |
| Concentration | 0.25 mg/mL |
| Antigen | Phospho-EGFR (Tyr1086) |
| Gene Symbols | EGFR |
| Regulatory Status | RUO |
| Purification Method | Antigen affinity chromatography |
| Gene Alias | 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2 |
| Gene | EGFR |
| Product Type | Antibody |
| Gene ID (Entrez) | 13649, 1956, 24329 |
| Formulation | PBS with 0.1% sodium azide; pH 7.4 |
| Immunogen | Synthetic peptide derived from the region surrounding the phosphorylated Tyr1086 residue of the human, mouse, rat, and pig epidermal growth factor receptor (EGFr) protein. |
| Classification | Polyclonal |
| Primary or Secondary | Primary |
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CD155 Monoclonal Antibody (2H7CD155), Super Bright™ 436, eBioscience™, Invitrogen™
CD155 Monoclonal Antibody (2H7CD155), Super Bright™ 436, eBioscience™, Invitrogen™
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Mouse Monoclonal Antibody
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| Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
|---|---|
| Target Species | Human |
| Host Species | Mouse |
| Conjugate | Super Bright 436 |
| Applications | Flow Cytometry |
| Form | Liquid |
| Isotype | IgG1 κ |
| Gene Accession No. | P15151 |
| Concentration | 5 μL/Test |
| Antigen | CD155 |
| Gene Symbols | PVR |
| Regulatory Status | RUO |
| Gene | PVR |
| Product Type | Antibody |
| Gene ID (Entrez) | 5817 |
| Classification | Monoclonal |
| Primary or Secondary | Primary |
| Clone | 2H7CD155 |
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CD23 Monoclonal Antibody (EBVCS2), Super Bright™ 600, eBioscience™, Invitrogen™
CD23 Monoclonal Antibody (EBVCS2), Super Bright™ 600, eBioscience™, Invitrogen™
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Mouse Monoclonal Antibody
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| Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
|---|---|
| Target Species | Human |
| Host Species | Mouse |
| Conjugate | Super Bright 600 |
| Applications | Flow Cytometry |
| Form | Liquid |
| Isotype | IgG1 κ |
| Gene Accession No. | P06734 |
| Concentration | 5 μL/Test |
| Antigen | CD23 |
| Gene Symbols | FCER2 |
| Regulatory Status | RUO |
| Purification Method | Affinity chromatography |
| Gene Alias | BLAST-2; CD23; CD23 antigen; CD23A; CLEC4J; C-type lectin domain family 4 member J; C-type lectin domain family 4, member J; Fc epsilon receptor II; FC epsilon RII; Fc fragment of IgE receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc receptor alpha multiple ligand receptor; Fc receptor, IgE, low affinity II, alpha polypeptide; Fcalpha muR; Fcalpha RII; Fce2; fc-epsilon-RII; FCER2; Fcer2a; FceRII; IGEBF; Immunoglobulin E-binding factor; immunoglobulin epsilon-chain; low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; low-affinity IgE receptor; Ly-42; lymphocyte IgE receptor |
| Gene | FCER2 |
| Product Type | Antibody |
| Gene ID (Entrez) | 2208 |
| Formulation | PBS with BSA and 0.09% sodium azide; pH 7.2 |
| Classification | Monoclonal |
| Primary or Secondary | Primary |
| Clone | EBVCS2 |
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Invitrogen™ Dengue Virus Type 2 Envelope Polyclonal Antibody
Invitrogen™ Dengue Virus Type 2 Envelope Polyclonal Antibody
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Rabbit Polyclonal Antibody
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
|---|---|
| Target Species | Virus |
| Host Species | Rabbit |
| Conjugate | Unconjugated |
| Applications | ELISA,Immunohistochemistry (Paraffin),Western Blot,Immunocytochemistry |
| Form | Liquid |
| Isotype | IgG |
| Concentration | 1.3 mg/mL |
| Antigen | Dengue Virus Type 2 Envelope |
| Regulatory Status | RUO |
| Purification Method | Antigen affinity chromatography |
| Gene Alias | Dengue 2 envelope; Dengue envelope; envelope protein |
| Product Type | Antibody |
| Formulation | PBS with 20% glycerol and 0.025% ProClin 300; pH 7 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of Dengue virus Envelope protein (Dengue virus 2 (strain 16681 PDK 53)). The exact sequence is proprietary. |
| Classification | Polyclonal |
| Primary or Secondary | Primary |