Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD131 mAb
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3 IL-5 and CSF Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP)
ABclonal Technology PE Rabbit anti-Human CD45RB
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology APC Rabbit anti-Mouse CD19
Involved in several processes including B-1 B cell differentiation positive regulation of phosphatidylinositol 3-kinase activity and positive regulation of release of sequestered calcium ion into cytosol Acts upstream of or within B cell receptor signaling pathway Located in external side of plasma membrane Is integral component of plasma membrane Is expressed in liver and spleen Human ortholog(s) of this gene implicated in common variable immunodeficiency Orthologous to human CD19 (CD19 molecule)
ABclonal Technology APC Rabbit anti-Mouse CD19
Involved in several processes including B-1 B cell differentiation positive regulation of phosphatidylinositol 3-kinase activity and positive regulation of release of sequestered calcium ion into cytosol Acts upstream of or within B cell receptor signaling pathway Located in external side of plasma membrane Is integral component of plasma membrane Is expressed in liver and spleen Human ortholog(s) of this gene implicated in common variable immunodeficiency Orthologous to human CD19 (CD19 molecule)
ABclonal Technology PE Rabbit anti-Mouse CD22 mAb
Enables CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in several processes including negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production and regulation of B cell proliferation Located in external side of plasma membrane and neuronal cell body membrane Is integral component of plasma membrane Is expressed in several structures including alimentary system brain hemolymphoid system gland liver and biliary system and reproductive system Orthologous to human CD22 (CD22 molecule)
ABclonal Technology PE Rabbit anti-Mouse/Rat CD54
This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1 It participates in the innate immune response
ABclonal Technology 647 Rabbit anti-Human CaSR
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling and thus this protein plays an essential role in maintaining mineral ion homeostasis Mutations in this gene are a cause of familial hypocalciuric hypercalcemia neonatal severe hyperparathyroidism and autosomal dominant hypocalcemia
ABclonal Technology 647 Rabbit anti- IL1R1/CD121a
Enables interleukin-1 binding activity interleukin-1 receptor activity and protease binding activity Involved in interleukin-1-mediated signaling pathway Acts upstream of or within several processes including cytokine-mediated signaling pathway positive regulation of interleukin-1-mediated signaling pathway and positive regulation of neutrophil extravasation Located in external side of plasma membrane Is expressed in brain dorsal aorta liver reproductive system and spleen Used to study type 1 diabetes mellitus Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus Orthologous to human IL1R1 (interleukin 1 receptor type 1)
ABclonal Technology APC Rabbit anti-Human IL-17A
This gene encodes a proinflammatory cytokine from the IL-17 receptor family primarily produced by activated T cells IL-17A activates pathways that induce inflammatory molecules chemokines antimicrobial peptides and tissue remodeling proteins It plays key roles in host defense immune modulation and tissue repair by promoting chemokine production and recruiting myeloid cells to sites of inflammation IL-17A also regulates NF- B and MAPK pathways and stimulates expression of IL6 COX-2 and nitric oxide It is implicated in infections autoimmune diseases cancer and contributes to lung damage in severe COVID-19
ABclonal Technology PE Rabbit anti-Human CD138 mAb
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology PE Rabbit anti-Human CD138 mAb
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology PE Rabbit anti-Human CD80/B7-1
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4 The activated protein induces T-cell proliferation and cytokine production This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy
ABclonal Technology 647 Rabbit anti-Rat IgG2b Fc
Enables antigen binding activity Acts upstream of or within phagocytosis positive regulation of immune response and positive regulation of phagocytosis Located in extracellular space Part of immunoglobulin complex circulating Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))
ABclonal Technology Phospho-NFKB1-S337 Rabbit
This gene encodes a 105 kD protein that is processed by the 26S proteasome into a 50 kD protein The 105 kD protein inhibits Rel protein-specific transcription while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is activated by various stimuli like cytokines free radicals UV irradiation and pathogens Once activated NFKB translocates to the nucleus to regulate genes involved in many biological functions Dysregulation of NFKB activation is linked to inflammatory diseases immune cell development issues and impaired cell growth NFKB is key in the immediate-early response to viral infections Alternative splicing produces multiple isoforms including one that undergoes proteolytic processing
ABclonal Technology Phospho-NFKB1-S337 Rabbit
This gene encodes a 105 kD protein that is processed by the 26S proteasome into a 50 kD protein The 105 kD protein inhibits Rel protein-specific transcription while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is activated by various stimuli like cytokines free radicals UV irradiation and pathogens Once activated NFKB translocates to the nucleus to regulate genes involved in many biological functions Dysregulation of NFKB activation is linked to inflammatory diseases immune cell development issues and impaired cell growth NFKB is key in the immediate-early response to viral infections Alternative splicing produces multiple isoforms including one that undergoes proteolytic processing