Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD28 mAb
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human ULBP2
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety or secreted Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6
ABclonal Technology 610 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology GPR55 Rabbit pAb
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways.
ABclonal Technology 647 Rabbit anti-Human CD11a
ITGAL encodes the integrin alpha L chain Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1) which is expressed on all leukocytes LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAMs 1-3 (intercellular adhesion molecules 1 through 3) and also functions in lymphocyte costimulatory signaling Two transcript variants encoding different isoforms have been found for this gene
Abcam Rabbit Anti-Human IgG H&L (DyLight 550) preadsorbed.
Rabbit Anti-Human IgG H&L (DyLight 550) preadsorbed.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology PE Rabbit anti-Human CD45RB
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 700 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 488 Rabbit anti-Human CEACAM6
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma This gene affects the sensitivity of tumor cells to adenovirus infection The protein encoded by this gene acts as a receptor for adherent-invasive E coli adhesion to the surface of ileal epithelial cells in patients with Crohn s disease This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983]) [supplied by OMIM May 2010]
ABclonal Technology 488 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human TNF-a
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to and thus functions through its receptors TNFRSF1A TNFR1 and TNFRSF1B TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation differentiation apoptosis lipid metabolism and coagulation This cytokine has been implicated in a variety of diseases including autoimmune diseases insulin resistance psoriasis rheumatoid arthritis ankylosing spondylitis tuberculosis autosomal dominant polycystic kidney disease and cancer Mutations in this gene affect susceptibility to cerebral malaria septic shock and Alzheimer disease Knockout studies in mice also suggested the neuroprotective function of this cytokine
ABclonal Technology 450 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human IL23R
The protein encoded by this gene is a subunit of the receptor for IL23A IL23 This protein pairs with the receptor molecule IL12RB1 IL12Rbeta1 and both are required for IL23A signaling This protein associates constitutively with Janus kinase 2 (JAK2) and also binds to transcription activator STAT3 in a ligand-dependent manner
ABclonal Technology 488 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit