Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Mouse CD45 mAb
This gene encodes a protein with heparan sulfate proteoglycan binding heparin binding and protein tyrosine phosphatase activity It plays roles in lymphocyte differentiation regulation of signal transduction and macromolecule metabolism It also regulates lymphocyte activation and protein phosphorylation The protein is found on the external side of the plasma membrane in focal adhesions and membrane rafts It is expressed in various tissues including the branchial arch cardiovascular and hemolymphoid systems and placenta It is studied in systemic lupus erythematosus and is orthologous to human PTPRC linked to hepatitis C multiple sclerosis and forms of severe combined immunodeficiency
ABclonal Technology 647 Rabbit anti- CD272/BTLA
Enables signaling receptor activity Acts upstream of or within immune response-regulating cell surface receptor signaling pathway negative regulation of B cell proliferation and negative regulation of alpha-beta T cell proliferation Located in external side of plasma membrane Is integral component of plasma membrane Orthologous to human BTLA (B and T lymphocyte associated)
ABclonal Technology Rabbit Anti-Human IgG2 Fc mAb
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to be involved in several processes including activation of immune response defense response to other organism and phagocytosis Located in extracellular space
ABclonal Technology 488 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants
ABclonal Technology 594 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology 594 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology PE Rabbit anti-Mouse CD14 mAb
This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte macrophage cells This gene product acts as a co-receptor that binds several microbial and fungal molecules including lipopolysaccharides (LPS) This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex The product of this gene is found in two forms either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor
ABclonal Technology PE Rabbit anti-Mouse CD14 mAb
This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte macrophage cells This gene product acts as a co-receptor that binds several microbial and fungal molecules including lipopolysaccharides (LPS) This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex The product of this gene is found in two forms either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor
ABclonal Technology H2-Ab1 Rabbit mAb
Enables several functions including peptide antigen binding activity protein antigen binding activity and toxic substance binding activity Involved in several processes including B cell affinity maturation cellular response to interferon-gamma and positive regulation of T-helper 1 type immune response Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response Located in Golgi apparatus endosome and external side of plasma membrane Is integral component of membrane Part of MHC class II protein complex Is expressed in lung metanephros and thymus primordium Orthologous to human HLA-DQB2 (major histocompatibility complex class II DQ beta 2)
ABclonal Technology APC Rabbit anti-Human CD161
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation Several genes of the C-type lectin superfamily including the rodent NKRP1 family of glycoproteins are expressed by NK cells and may be involved in the regulation of NK cell function The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins a transmembrane domain and a cytoplasmic domain The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus
ABclonal Technology APC Rabbit anti-Human CD42b
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer an alpha chain and a beta chain that is linked by disulfide bonds The Gp Ib functions as a receptor for von Willebrand factor (VWF) The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis This gene encodes the alpha subunit Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy
ABclonal Technology CD272/BTLA Rabbit mAb
Enables signaling receptor activity Acts upstream of or within immune response-regulating cell surface receptor signaling pathway negative regulation of B cell proliferation and negative regulation of alpha-beta T cell proliferation Located in external side of plasma membrane Is integral component of plasma membrane Orthologous to human BTLA (B and T lymphocyte associated)
ABclonal Technology PE Rabbit anti-Human CD161 mAb
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation Several genes of the C-type lectin superfamily including the rodent NKRP1 family of glycoproteins are expressed by NK cells and may be involved in the regulation of NK cell function The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins a transmembrane domain and a cytoplasmic domain The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus
ABclonal Technology PE Rabbit anti-Human CD161 mAb
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation Several genes of the C-type lectin superfamily including the rodent NKRP1 family of glycoproteins are expressed by NK cells and may be involved in the regulation of NK cell function The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins a transmembrane domain and a cytoplasmic domain The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus
ABclonal Technology ABflo 488 Rabbit anti- IL-13
Predicted to enable interleukin-13 receptor binding activity Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation Acts upstream of or within cellular response to cytokine stimulus inflammatory response and positive regulation of immune effector process Located in cytoplasm external side of plasma membrane and extracellular space Is expressed in gut liver male reproductive gland or organ and thymus Used to study atopic dermatitis Human ortholog(s) of this gene implicated in several diseases including allergic disease (multiple) autoimmune disease (multiple) diffuse scleroderma lung disease (multiple) and nose disease (multiple) Orthologous to human IL13 (interleukin 13)