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13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions{2227} and shown to be produced by Cu2 -catalyzed oxidation of LDL.{2228} Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate a major component of LDL to 13-HODE cholesteryl ester.{11262412}
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An inhibitor of the gp130-IL-6/IL6Ra protein-protein interaction binds to gp130 (Kd 7.4 UM) and selectively inhibits IL-6-induced STAT3 phosphorylation over leukemia inhibitor factor- or phorbol 12-myristate 13-acetate-induced STAT3 phosphorylation in HepG2 cells at 10 30 or 100 UM reduces IL-6-induced increases in the viability of GM-CSF-starved TF-1 leukemia cells at 10 to 1000 nM inhibits the LPS- and AGE-induced increases in mRNA encoding Rankl as well as inhibits increases in the phosphorylation levels of gp130 Stat3 and Jak2 in mouse MC3T3-E1 osteoblasts at 100 nM decreases joint and paw swelling as well as serum levels of COMP SAP and anti-collagen II antibodies in a mouse model of collagen-induced arthritis at 0.25 mg/kg per day reduces bone resorption height and volume in a rat model of type 2 diabetes peri-implantitis induced by LPS P. gingivalis and a high-fat and high-sUGar diet at 0.23 mg/kg per day p.o.
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A glucocorticoid receptor agonist and an active metabolite of beclomethasone dipropionate binds to the glucocorticoid receptor (IC50 3 nM) inhibits PMA-induced glucocorticoid receptor transrepression as well as induces transactivation of the glucocorticoid receptor in CV-1 cells expressing the human receptor inhibits LPS-induced increases in IL-6 IL-8 and TNF-a levels in primary human lung macrophages from patients with COPD (IC50s 0.36 2.04 and 0.21 nM respectively)
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