Modifying Enzymes
Sino Biological Recombinant DNase I (RNase-free) 5000 U
DNase I is an endonuclease that can non-specifically cleave DNA, producing dinucleotide, trinucleotide, and oligonucleotide products with 5 ́ phosphorylated and 3 ́ hydroxylated ends. DNase I acts on single-and double-stranded DNA, chromatin, and RNA:DNA hybrid strands. Certified by highly sensitive fluorescence probe assays, our DNase I (RNase-free) demonstrates virtually undetectable RNase activity-a level of purity that surpasses other commercial sources. Trust in this "Ultra-Pure" standard for the ultimate reliability in your RNase-sensitive workflows.
Biotium CD45 / LCA (Leucocyte Marker)(Bra55), CF594 conjugate, 0.1mg/mL
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
Cayman Chemical N-Oleoyl ValIn 25mg
An endogenous N-acyl amine; antagonist at TRPV3; increases after acute lung injury in mouse lung tissue
Medchemexpress LLC Tlr4-in-c34-c2-cooh | 1159408-54-4 | MFCD30802159 | 99.9% | 447.43 g/mol | C19H29NO11 | 100 MG
TLR4-IN-C34-C2-COOH is a small-molecule PROTAC linker that incorporates a TLR4 inhibitor moiety and is supplied for research use to support studies of TLR4 biology and probe or degrader synthesis. It has documented activity inhibiting TLR4 in enterocytes and macrophages and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
- High purity of 99.9%.
- Molecular formula C19H29NO11; molecular weight 447.43 g/mol.
- Soluble in DMSO and water at 100 mg/mL with ultrasonic assistance.
- Formulation examples yield ≥ 2.5 mg/mL (5.59 mM) in common in vivo vehicles.
- Available in multiple pack sizes including 100 mg.
- Intended for research use only; not for human or veterinary use.
STEMCELL Technologies DNase I, ACF, Size: 500000 U
Deoxyribonuclease I (DNase I), Animal Component-Free (ACF) is obtained from cultures free of animal-derived materials and purified by chromatography. DNase I is an endonuclease consisting of a single glycosylated polypeptide chain with two disulfide bonds. DNase is often included in tissue dissociation protocols to digest DNA that has leaked into the dissociation medium as a result of cell damage. DNase I, ACF preferentially cleaves phosphodiester linkages adjacent to pyrimidine nucleotides in both single- and double-stranded DNA, yielding polynucleotides with 5’-phosphate and 3’-hydroxyl groups (Bernardi et al.). DNase I has been used for the digestion of human tissues such as microglia (Klegeris & McGeer), cartilage (Dunham & Koch), colon (Fukushima & Fiocchi), epithelium l (Fukushima & Fiocchi), liver (Vatakis et al.), lung (Fujino et al.), neural (Fuja et al.), and stem cells (Kusuma et al.).
Chem-Impex International, Inc. Proteinase K from Tritirachium album [EC 3.4.21.64] | 39450-01-6 | MFCD00132129 | 1G
Proteinase K from Tritirachium album [EC 3.4.21.64], 39450-01-6, MFCD00132129, 1G
Meridian Life Science Gly-Free RNase H -HC, 20UL
Glycerol-Free RNase H (HC) is a high concentration (50 U/uL) RNA-specific endonuclease that hydrolyzes the phosphodiester bonds of RNA, when hybridized to DNA and produces 5´ phosphate-terminated oligoribonucleotides and single-stranded DNA. It does not hydrolyze the phosphodiester bonds within single-stranded and double-stranded DNA and RNA. Glycerol-Free RNase H (HC) has been optimized to deliver excellent, stable performance without glycerol, allowing you to deliver reliable results with the added capability for lyophilization. This gives you the flexibility to confidently store reaction mixtures at ambient temperature or produce diagnostic assays that rely on miniaturized reaction components.
Cayman Chemical 3-Phenylpropanoyl-Coenzyme A
A medium-chain and phenyl-substituted acyl CoA; has been used as an enzymatic substrate in potential screening assays for MCAD deficiency in newborn-derived primary fibroblasts
Medchemexpress LLC 2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)- | 1479576 | MFCD15146947 | 99.8% | 273.33 g/mol | C16H19NO3 | 5 MG
Piperlonguminine is an alkaloid amide used in biochemical and pharmacological research to investigate anti-inflammatory, antitumor, neuroprotective, and antimicrobial mechanisms. The reagent is provided as a characterized, research-grade compound with molecular formula C16H19NO3 and molecular weight 273.33 g/mol.
- High purity (99.8%).
- Characterized with analytical data (HNMR, CNMR, LCMS).
- Suitable for in vitro bioactivity screening and mechanistic studies.
- Available in small-vial quantities for screening, e.g., 5 mg.
- Downloadable datasheet, COA, and SDS available.
Cayman Chemical N-Oleoyl ProlIn 25mg
An endogenous N-acyl amine that is decreased in lumbar spinal cord after capsaicin administration (1 UG/10 µl) and has surfactant properties (critical micelle concentration = 4.8 µM)
Carnabio Usa Inc TEC/5UG/CATALYTIC
TEC, Catalytic domain, Wild type, Amino Acid 359-631, AAI01712.1, Expressed in Insect (sf21); 5microg
Medchemexpress LLC α-Amylase from Aspergillus oryzae | 9001-19-8 | ≥100 U/mg solid | 5 G
Alpha-Amylase from Aspergillus oryzae is an amylase commonly used for various biochemical studies. This enzyme appears as a white to off-white solid and can be dissolved in water or other specific experimental reference literature as needed.
- Used for various biochemical studies
- Classified as an amylase enzyme
- Appears as a white to off-white solid
- Has an EC number of 3.2.1.1
- Exhibits enzyme activity of ≥100 U/mg solid
- Can be dissolved in water or according to specific experimental reference literature
Bioss KD-Validated DNA ligase 4 Rabb
DNA Ligase 4 Primary Antibody Unconjugated Public Immunogen Range 504-685/911 Host Species Rabbit Target Species Human Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
ABclonal Technology RNase A (Powder)
Ribonuclease A (RNase A), molecular weight 13.7 kDa, is an endonuclease that specifically acts on the 3 end of the pyrimidine residue on RNA, cleaving phosphodiester bonds formed with adjacent nucleotides, and the final product of the reaction is pyrimidine 3 phosphate and an oligonucleotide with pyrimidine 3 phosphate at the end. RNase A does not work on DNA.This product is sourced from bovine pancreas and is supplied in the form of white lyophilized powder with enzyme activity ≥ 50 Kunitz units/mg protein. Its recommended working concentration is 1-100 μg/mL, which will vary depending on specific applications.