General Clinical Chemistry Analyzers and Accessories
Nova Biomedical Corporation Bioprofile Flex PCO2 Electrode, instrument
Bioprofile Flex PCO2 Electrode. BioProfile is a chemistry/cell viability modular instrument that measures up to 15 key cell culture attributes. By combining as many as five separate instruments into one easy-to-use instrument, BioProfile FLEX simplifies workflow and saves time, labor, and operating cost versus multiple instruments.
Abcam G10, STING signaling activator, 25MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CUR 61414, Hedgehog signaling pathway antagonist, 5MG
MW 550.7 Da, Purity >98%. Novel, cell permeable Hedgehog signaling pathway antagonist (IC₅₀ = 100-200 nM). Selectively binds to smoothened (Smo) (Ki = 44 nM). Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam BIIB 021, 25MG
MW 318.76 Da, Purity >98%. Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC₅₀ = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.
The product is subject to the following: Abcam Restricted Use Statement
Roche Diagnostics Stains Liquid Coverslip, One each
LCS It is Ventana reagent required but not supplied with ChipMap kit
YSI 3P LifeScience MEMBRANES GLUCOSE 4/PK
The 2365 glucose membrane comes in a 4-pack and is a related reagent to be used with the YSI 2300 STAT Glucose and Lactate Analyzer.
Abcam 4'-hydro x yazobenzene-2-carbo x ylic acid (HABA), 5G
MW 242.23 Da. An endogenous metabolite. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LGK974, 5MG
MW 396.4 Da, Purity >=98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 5MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam EHop-016, Rac GTPase inhibitor, 5MG
MW 430.5 Da, Purity >98%. Specific Rac GTPase inhibitor. Analog of NSC-23766 (ab142161). Approximately 100-fold more potent against Rac (IC₅₀ = 1.1 μM) than NSC-23766. Specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations (10μM) inhibits the the related Rho GTPase Cdc42. Also inhibits the activity of the Rac downstream effector p21-activated kinase (PAK), lamellipodia extension, and cell migration in metastatic cancer cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ganetespib (STA-9090), 5MG
MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC₅₀ of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC₅₀ of 43 nM.
The product is subject to the following: Abcam Restricted Use Statement
Perkin Elmer US LLC Copper Diffusion Plug
The best way to assure consistent, accurate results from your Organic Elemental Analyzer is to use only the highestgrade of reagents. Our scientists select the purest raw materials, condition them,then test them on PerkinElmer analyzers.