General Clinical Chemistry Analyzers and Accessories
Abcam SIS3, Smad3 inhibitor, 5MG
MW 490 Da, Purity >98%. Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CUR 61414, Hedgehog signaling pathway antagonist, 25MG
MW 550.7 Da, Purity >98%. Novel, cell permeable Hedgehog signaling pathway antagonist (IC₅₀ = 100-200 nM). Selectively binds to smoothened (Smo) (Ki = 44 nM). Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GLPG-1690, 5MG
MW 588.7 Da, Purity >=98%. Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Anidulafungin, 25MG
MW 1140.2 g/mol, Purity >=95%. Inhibits fungal (1→3)-β-D-glucan synthase. Potent in vitro activity against Aspergillus and Candida species (MIC₅₀ of 0.03 to 4 μg/ml), including those resistant to fluconazole or amphotericin B. Effective in treating esophageal candidiasis in clinical trials.
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 1MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam V x -745, p38 alpha MAPK inhibitor, 10MG
MW 436.3 Da. Potent, selective p38 alpha MAPK inhibitor (IC₅₀ = 10 nM), with 20-fold selectivity over p38 beta and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Binimetinib, MEK1/2 inhibitor, 25MG
MW 441.2 Da, Purity >99%. Potent and selective allosteric inhibitor of MEK1/2. Orally bioavailable. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WAY-316606, 5MG
MW 448.5 Da, Purity >=98%. A secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM). It blocks sFRP-1 from interacting with Wnt and thus increases Wnt signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB742457 (Intepirdine), 5-HT6 antagonist, 25MG
MW 353.4 Da. Potent (pKi = 9.63) and highly selective 5-HT6 antagonist. Greater thsan 100-fold selective against other receptors. Reverses learning impairment in animal models.
The product is subject to the following: Abcam Restricted Use Statement
Abcam UC2288, p21 inhibitor, 25MG
MW 481.8 Da, Purity >98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI₅₀ = ~ 10 μM against NCI60 cell lines).
The product is subject to the following: Abcam Restricted Use Statement
Roche Diagnostics Glycerol Bio HT
Test kit for the Cedex Bio HT Analyzer. For use in quality control / manufacturing process only.
Rarecyte RareCyte AccuCyte CyteSpreader Tray
A reusable metal tray with a bubble level, level adjustment knobs and eight, grey, plastic bases to hold eight microscope slides. The plastic bases have a plastic guide to enable moving the CyteSpreader blade onto the microscope slide to help evenly distribute a monolayer of sample onto a microscope slide.
Abcam Dovitinib, class III-V receptor tyrosine kinase inhibitor, 25MG
MW 392.4 Da, Purity >99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC₅₀ = 1 nM), c-KIT (IC₅₀ = 2 nM), FGFR (IC₅₀ = 8 nM), VEGFR1/2/3 (IC₅₀ values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC₅₀ = 27 nM), and CSF-1R (IC₅₀ = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
The product is subject to the following: Abcam Restricted Use Statement
