Custom Peptides
Cayman Chemical D-GlucosamIn-6-sulfate 10mg
A glycosaminoglycan; activates the glmS ribozyme from B. subtilis (200 µM); has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis, cell proliferation, and scar tissue formation
Cayman Chemical GSK2200150A 10mg
An antimycobacterial agent; active against M. tuberculosis and M. bovis (MICs = 0.38 and 1.6 µM, respectively)
Cayman Chemical NourseothrIcInsulfate 10mg
A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding; commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells
Cayman Chemical Borusertb 10mg
An Akt1 and Akt2 inhibitor (Kis = 2 and 6 nM, respectively); selective for Akt1 and Akt2 over Akt3 (Ki = 91 nM); reduces viability in Ba/F3 cells expressing human Akt1 or Akt2 but not Ba/F3 cells expressing human Akt3 at 5 µM; decreases the levels of phosphorylated Akt1, Akt2, PRAS40, and ribosomal protein S6 in PANC-1 cancer cells at concentrations of 0.3 to 5 µM; prevents tumor growth in combination with trametinib in three PDX mouse models of K-Ras-mutant colorectal cancer at 20 mg/kg per day
Cayman Chemical 4 DImethylamIno1methylpyr 10mg
A pyridinium salt with anticholinesterase and antiproliferative activities; inhibits cholinesterase activity in rat brain homogenates (Kd = 33 μM); inhibits and yeast ChoK (IC50 = 17 μM); has antiproliferative activity against HT-29 colon cancer cells (IC50 = 2 μM)
Cayman Chemical StemRegenIn 1hydrochLRIde 10mg
A purine derivative that reversibly antagonizes aryl hydrocarbon receptor signaling (IC50 = 127 nM in CD34+ cells); induces a 50-fold increase in human embryonic stem cells expressing CD34 (EC50 = 120 nM) and a 17-fold increase in stem cells that retain the ability to engraft immunodeficient mice
Cayman Chemical Gnoderol B 10mg
A triterpenoid with diverse biological activities; inhibits ACE and α-glucosidase (IC50s = 220 and 119.8 µM, respectively); cytotoxic to HGC-27, HeLa, and A549 cells (IC50s = 16.15, 12.64, and 9.77 µM, respectively); prevents HSV-1 infection in Vero cells (EC50 = 68 µM); reduces testosterone-induced increases in ventral prostate weight in castrated rats at 0.001 and 0.1 mg/kg
Cayman Chemical Uncaa yncopyla sutn 10mg
An indole with diverse biological activities; selectively inhibits BChE (IC50s = 1.97 and 4.97 µM for the human and horse enzymes, respectively) over AChE, for which it has no activity; an inhibitor of 5-HT3A and 5-HT3AB (IC50s = 65.35 and 28.44 µM, respectively); reduces glutamate-induced increases in cell death in HT22 cells at 50 and 100 µM; induces apoptosis in A549 and H1299 NSCLC cells at 40, 60, and 80 µM; reduces tumor growth and intratumoral levels of phosphorylated GSK3β in an A549 mouse xenograft model at 10 mg/kg; also reduces infarct size and cardiac cell apoptosis and prevents cardiac dysfunction in a rat model of ischemia-reperfusion injury at 20 mg/kg
Cayman Chemical 5a-ndrost-16-en-3a-ol 10mg
A pheromone with diverse biological activities; enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM); increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors from 0.1-1 µM; has antidepressant-like effects in mice from 5-10 mg/kg; has anxiolytic-like effects in mice from 30-50 mg/kg; protects against PTZ- or electroshock-induced seizures in mice (ED50s = 48.9 and 21.9 mg/kg, respectively)
Cayman Chemical CInamtnIn B-1 10mg
A polyphenol antioxidant; inhibits lipid peroxidation in vitro (IC50 = 2.25 µM); improves wound healing in mice; COX-2 inhibitor with 19, 27, and 86% inhibition in Sf9 cells at 10, 100, and 1,000 UG/ml, respectively
Cayman Chemical 4-hydroxy MET 10mg
An analytical reference standard categorized as a tryptamine; induces the HTR in mice; intended for research and forensic applications
Cayman Chemical Tafenoqun 10mg
An antimalarial agent; active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml); inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice at 25 or 50 mg/kg; suppresses parasitemia in a hamster model of B. microti infection from 3.25-52 mg/kg
Cayman Chemical 4-bromo A23187 10mg
A non-fluorescent analog of the highly selective calcium ionophore A23187; used in experiments where fluorescent probes are employed
Cayman Chemical 3 3 5-TrIIodo-L-thyronIn 10mg
A thyroid hormone that is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than T3; activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm, initiating actin polymerization
Cayman Chemical AsunaprevIr 10mg
An inhibitor of HCV NS3/4A serine protease; a direct-acting inhibitor of hepatitis C virus (HCV)