Custom Peptides
Cayman Chemical penIcIlum cItrInum cItrn 10mg
A mycotoxin with diverse biological activities; active against S. aureus, MRSA, rifampicin-resistant S. aureus, and vancomycin-resistant E. faecium (MICs = 1.95, 3.9, 0.97, and 7.81 UG/ml, respectively), as well as C. neoformans (MIC = 3.9 UG/ml); induces ROS production, mitochondrial membrane potential loss, and apoptosis in HepG2 cells at 30 µM and is cytotoxic to a variety of cells in vitro; reduces glutamate-induced excitotoxicity in primary rat cortical neurons at 0.1-1,000 nM; inhibits LPS-induced NO production in RAW 264.7 cells at 0.625-40 µM; toxic to brine shrimp larvae (LD50 = 96 UG/ml); toxic to rats and mice (oral LD50s = 50 and 87-105 mg/kg, respectively)
Cayman Chemical Asprgls fumIgatus Fumagln 10mg
A fungal metabolite with diverse biological activities; inhibits METAP2 (IC50 = 10 nM); inhibits tube formation in a rat blood vessel organ culture assay at 10 ng/ml; inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells at 5 UG/ml; decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma at 30 mg/kg; reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity
Cayman Chemical PlatycodIn D 10mg
A saponin isolated from the root of P. grandiflorum, which has been used extensively in Chinese herbal medicine for many applications
Cayman Chemical MAM2201 N 3fluoropentyl Is
Differs from MAM2201 by having fluorine at the 3 position rather than the 5 position of the alkyl chain; intended for forensic and research applications
Cayman Chemical CardIogenol ChydrochLRIde 10mg
Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM
Cayman Chemical 3 4MethylendIoxy5methylet 10mg
An analog of the cathinone bk-MDEA, differing by the addition of a methyl group at the two position of the benzene ring
Cayman Chemical ProtodIoscIn 10mg
A natural steroidal saponin; cytotoxic to a range of cancer cells in vitro, including leukemia, colon cancer, and prostate cancer cells (GI50 ≤ 2 µM)
Cayman Chemical AsIatIcosIde 10mg
The main saponin constituent of C. asiatica that has been shown to improve wound healing including increasing collagen synthesis and elevating antioxidant levels in various normal and diabetic wound models
Cayman Chemical DSmethyl MIrtazapInhydroc 10mg
A metabolite of mirtazapine; formed from mirtazapine by CYP3A4
Cayman Chemical CarbamazepIn 10 11epoxIde 10mg
An active metabolite of carbamazepine; has anticonvulsant activity against maximal electroshock-induced seizures in mice; has been found in wastewater effluent
Cayman Chemical MetIprnolol 10mg
A β-AR antagonist; binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM); inhibits isoproterenol-induced relaxation in guinea pig atrium and fenoterol-induced relaxation in rat uterus (pA2s = 8.3 and 8.4, respectively); inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates (100 μM); decreases α-chymotrypsin-induced increases in IOP in rabbits when administered topically to the eye at a dose of 0.3%; inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%
Cayman Chemical GnoderIc AcId C1 10mg
A triterpenoid; inhibits ACE (IC50 = 745 µM); inhibits HIV-1 protease (IC50 = 180 µM); reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth A sarcoma cells (EC50s = 17 and >20 UG/ml, respectively); inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells and PBMCs isolated from patients with asthma at 20 UG/ml
Cayman Chemical 28Deoxybetuln mthylenamIn 10mg
A derivative of betulin; has been used in the synthesis of triterpene derivatives with antiviral activity
Cayman Chemical SalInomycIn 10mg
An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC50 = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary tumor growth and induces increased epithelial differentiation of tumor cells in mice implanted with SUM159 human breast cancer cells
Cayman Chemical BIcyclo ProstaglndIn E1 10mg
Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo PGE1 is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. 13,14-dihydro-15-keto PGE1 itself is a metabolite of PGE1{182,2126} found in human plasma at a median level of 10 pg/ml.{4383} Due to the inherent instability of 13,14-dihydro-15-keto PGE1, it is advisable to quantify it as bicyclo PGE1 to estimate PGE1 biosynthesis or metabolism in vivo.